Skip to main content
main-content

Tip

Swipe om te navigeren naar een ander artikel

04-09-2015 | Original Paper | Uitgave 2/2016 Open Access

Journal of Autism and Developmental Disorders 2/2016

Does the cognitive architecture of simplex and multiplex ASD families differ?

Tijdschrift:
Journal of Autism and Developmental Disorders > Uitgave 2/2016
Auteurs:
Anoek M. Oerlemans, Catharina A. Hartman, Barbara Franke, Jan K. Buitelaar, Nanda N. J. Rommelse
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10803-015-2572-9) contains supplementary material, which is available to authorized users.

Abstract

Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD.

Onze productaanbevelingen

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijft u als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen uw vak. Met het online abonnement heeft u toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kunt u op uw gemak en wanneer het u het beste uitkomt verdiepen in uw vakgebied.

Extra materiaal
Supplementary material 1 (PDF 126 kb)
10803_2015_2572_MOESM1_ESM.pdf
Supplementary material 2 (PDF 26 kb)
10803_2015_2572_MOESM2_ESM.pdf
Literatuur
Over dit artikel

Andere artikelen Uitgave 2/2016

Journal of Autism and Developmental Disorders 2/2016Naar de uitgave

S.I. : Discourse and conversation analytic approaches to the study of ASD

A Multidimensional Reappraisal of Language in Autism: Insights from a Discourse Analytic Study

S.I. : Discourse and conversation analytic approaches to the study of ASD

Parents as a Team: Mother, Father, a Child with Autism Spectrum Disorder, and a Spinning Toy