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14-09-2015 | Original Paper | Uitgave 2/2016

Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 2/2016

Auteurs:: Gayle C. Windham, Kristen Lyall, Meredith Anderson, Martin Kharrazi

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The online version of this article (doi:10.1007/s10803-015-2587-2) contains supplementary material, which is available to authorized users.

Abstract

We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk.

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Titel: Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California
Auteurs:: Gayle C. Windham
Kristen Lyall
Meredith Anderson
Martin Kharrazi
Publicatiedatum: 14-09-2015
DOI: https://doi.org/10.1007/s10803-015-2587-2
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 2/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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