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Journal of Autism and Developmental Disorders
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12-01-2017 | Original Paper

Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology

Auteurs: Ashley F. P. Sanders, Diana A. Hobbs, David D. Stephenson Jr., Robert D. Laird, Elliott A. Beaton

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2017

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Abstract

Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS.
vorige artikel Health Care Transition Planning Among Adolescents with Autism Spectrum Disorder
volgende artikel Do Handwriting Difficulties Correlate with Core Symptomology, Motor Proficiency and Attentional Behaviours?
Literatuur
Al’Absi, M., Hugdahl, K., & Lovallo, W. R. (2002). Adrenocortical stress responses and altered working memory performance. Psychophysiology, 39(1), 95–99.CrossRefPubMed
Angkustsiri, K., Goodlin-Jones, B., Deprey, L., Brahmbhatt, K., Harris, S., & Simon, T. J. (2014). Social impairments in chromosome 22q11. 2 deletion syndrome (22q11. 2DS): Autism spectrum disorder or a different endophenotype? Journal of Autism and Developmental Disorders, 44, 739–746.CrossRefPubMedPubMedCentral
Angkustsiri, K., Leckliter, I., Tartaglia, N., Beaton, E. A., Enriquez, J., & Simon, T. J. (2012). An examination of the relationship of anxiety and intelligence to adaptive functioning in children with chromosome 22q11. 2 deletion syndrome. Journal of Developmental and Behavioral Pediatrics, 33(9), 713.CrossRefPubMedPubMedCentral
Antshel, K. M., Shprintzen, R., Fremont, W., Higgins, A. M., Faraone, S. V., & Kates, W. R. (2010). Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up study. Journal of the American Academy of Child & Adolescent Psychiatry, 49(4), 333–344.
Barkley, R. A. (2014). Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment: New York: Guilford Publications.
Bearden, C. E., Woodin, M. F., Wang, P. P., Moss, E., McDonald-McGinn, D., Zackai, E., ... & Cannon, T. D. (2001). The neurocognitive phenotype of the 22q11. 2 deletion syndrome: selective deficit in visual-spatial memory. Journal of Clinical and Experimental Neuropsychology, 23(4), 447–464.CrossRefPubMed
Beaton, E. A., Angkustsiri, K., Leckliter, I., Cabaral, M. H., McLennan, Y. A., Enriquez, J., & Simon, T. J. (2014). Elevated anxiety, depression, and salivary cortisol in children with chromosome 22q11.2 deletion syndrome during a mild novel stressor. Paper presented at the Biological Psychiatry.
Beaton, E. A., & Simon, T. J. (2011). How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11. 2 deletion syndrome? Journal of Neurodevelopmental Disorders, 3(1), 68–75.CrossRefPubMed
Berntson, G. G., Bigger, J. T., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., ... Stone, & P, H. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34(6), 623–648.CrossRefPubMed
Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993). Respiratory sinus arrhythmia: Autonomic origins, physiological mechanisms, and psychophysiological implications. Psychophysiology, 30(2), 183–196.CrossRefPubMed
Bollen, K. A., & Stine, R. (1990). Direct and indirect effects: Classical and bootstrap estimates of variability. Sociological Methodology, 20(1), 15–140.
Boudarene, M., Legros, J., & Timsit-Berthier, M. (2001). [Study of the stress response: role of anxiety, cortisol and DHEAs]. L’Encephale, 28(2), 139–146.
Campbell, L. E., Azuma, R., Ambery, F., Stevens, A., Smith, A., Morris, R. G., ... Murphy, & K, C. (2010). Executive functions and memory abilities in children with 22q11. 2 deletion syndrome. Australian and New Zealand Journal of Psychiatry, 44(4), 364–371.CrossRefPubMed
Chaumette, B., Kebir, O., Mam-Lam-Fook, C., Morvan, Y., Bourgin, J., Godsil, B. P., ... Krebs, M.-O (2016). Salivary cortisol in early psychosis: New findings and meta-analysis. Psychoneuroendocrinology, 63, 262–270.CrossRefPubMed
Chida, Y., & Hamer, M. (2008). Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. Psychological Bulletin, 134(6), 829.CrossRefPubMed
Contarino, A., Dellu, F., Koob, G. F., Smith, G. W., Lee, K.-F., Vale, W., & Gold, L. H. (1999). Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Research, 835(1), 1–9.CrossRefPubMed
Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience, 3(3), 201–215.CrossRefPubMed
Dalgleish, T., Taghavi, R., Neshat-Doost, H., Moradi, A., Canterbury, R., & Yule, W. (2003). Patterns of processing bias for emotional information across clinical disorders: A comparison of attention, memory, and prospective cognition in children and adolescents with depression, generalized anxiety, and posttraumatic stress disorder. Journal of Clinical Child and Adolescent Psychology, 32(1), 10–21.CrossRefPubMed
Derakshan, N., & Eysenck, M. W. (2009). Anxiety, processing efficiency, and cognitive performance: New developments from attentional control theory. European Psychologist, 14(2), 168–176.CrossRef
Dickerson, S. S., & Kemeny, M. E. (2004). Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychological Bulletin, 130(3), 355.CrossRefPubMed
Eysenck, M. W., & Calvo, M. G. (1992). Anxiety and performance: The processing efficiency theory. Cognition & Emotion, 6(6), 409–434.CrossRef
Eysenck, M. W., & Derakshan, N. (2011). New perspectives in attentional control theory. Personality and Individual Differences, 50(7), 955–960.CrossRef
Eysenck, M. W., Derakshan, N., Santos, R., & Calvo, M. G. (2007). Anxiety and cognitive performance: attentional control theory. Emotion, 7(2), 336.CrossRefPubMed
Fabbro, A., Rizzi, E., Schneider, M., Debbane, M., & Eliez, S. (2012). Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS). European Child & Adolescent Psychiatry, 21(7), 379–385.CrossRef
Friedman, B. H., & Thayer, J. F. (1998). Autonomic balance revisited: panic anxiety and heart rate variability. Journal of Psychosomatic Research, 44(1), 133–151.CrossRefPubMed
Fusar-Poli, P., Bonoldi, I., Yung, A. R., Borgwardt, S., Kempton, M. J., Valmaggia, L., ... & McGuire, P. (2012). Predicting psychosis: Meta-analysis of transition outcomes in individuals at high clinical risk. Archives of General Psychiatry, 69(3), 220–229.CrossRefPubMed
Gothelf, D., Hoeft, F., Ueno, T., Sugiura, L., Lee, A. D., Thompson, P., & Reiss, A. L. (2011). Developmental changes in multivariate neuroanatomical patterns that predict risk for psychosis in 22q11. 2 deletion syndrome. Journal of Psychiatric Research, 45(3), 322–331.CrossRefPubMedPubMedCentral
Gothelf, D., Michaelovsky, E., Frisch, A., Zohar, A. H., Presburger, G., Burg, M., ... & Shohat, M. (2007). Association of the low-activity COMT 158 Met allele with ADHD and OCD in subjects with velocardiofacial syndrome. The International Journal of Neuropsychopharmacology, 10(03), 301–308.CrossRefPubMed
Gothelf, D., Schneider, M., Green, T., Debbané, M., Frisch, A., Glaser, B., ... & Eliez, S. (2013). Risk factors and the evolution of psychosis in 22q11. 2 deletion syndrome: a longitudinal 2-site study. Journal of the American Academy of Child & Adolescent Psychiatry, 52(11), 1192–1203. e1193.CrossRef
Green, T., Gothelf, D., Glaser, B., Debbane, M., Frisch, A., Kotler, M., ... & Eliez, S. (2009). Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11. 2 deletion) syndrome. Journal of the American Academy of Child & Adolescent Psychiatry, 48(11), 1060–1068.CrossRef
Harrison, F., Hosseini, A., & McDonald, M. (2009). Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behavioural Brain Research, 198(1), 247–251.CrossRefPubMed
Hooper, S. R., Curtiss, K., Schoch, K., Keshavan, M. S., Allen, A., & Shashi, V. (2013). A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11. 2 deletion syndrome. Research in Developmental Disabilities, 34(5), 1758–1769.CrossRefPubMedPubMedCentral
Howley, S. A., Prasad, S. E., Pender, N. P., & Murphy, K. C. (2012). Relationship between reaction time, fine motor control, and visual–spatial perception on vigilance and visual-motor tasks in 22q11. 2 Deletion Syndrome. Research in Developmental Disabilities, 33(5), 1495–1502.CrossRefPubMed
Jacobson, D., Bursch, M., & Lajiness-O’Neill, R. (2016). Potential role of cortisol in social and memory impairments in individuals with 22q11. 2 deletion syndrome. Journal of Pediatric Genetics, 5(03), 150–157.CrossRefPubMed
Kates, W. R., Krauss, B. R., AbdulSabur, N., Colgan, D., Antshel, K. M., Higgins, A. M., & Shprintzen, R. J. (2007). The neural correlates of non-spatial working memory in velocardiofacial syndrome (22q11. 2 deletion syndrome). Neuropsychologia, 45(12), 2863–2873.CrossRefPubMedPubMedCentral
Kenny, D. A., & Judd, C. M. (2013). Power anomalies in testing mediation. Psychological Science, 0956797613502676.
Kistler, A., Mariauzouls, C., & von Berlepsch, K. (1998). Fingertip temperature as an indicator for sympathetic responses. International Journal of Psychophysiology, 29(1), 35–41.CrossRefPubMed
Kushki, A., Drumm, E., Mobarak, M. P., Tanel, N., Dupuis, A., Chau, T., & Anagnostou, E. (2013). Investigating the autonomic nervous system response to anxiety in children with autism spectrum disorders. PLoS ONE, 8(4), e59730.CrossRefPubMedPubMedCentral
Lajiness-O’Neill, R. R., Beaulieu, I., Titus, J. B., Asamoah, A., Bigler, E. D., Bawle, E. V., & Pollack, R. (2005). Memory and learning in children with 22q11. 2 deletion syndrome: evidence for ventral and dorsal stream disruption? Child Neuropsychology, 11(1), 55–71.CrossRefPubMed
Lupien, S., Lecours, A. R., Lussier, I., Schwartz, G., Nair, N., & Meaney, M. J. (1994). Basal cortisol levels and cognitive deficits in human aging. The Journal of Neuroscience, 14(5), 2893–2903.PubMed
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., ... & Meaney, M. J. (1998). Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature Neuroscience, 1(1), 69–73.CrossRefPubMed
March, J. S. (2012). Mulidimensional anxiety scale for children 2nd edition. Toronto, Ontario: MHS.
McDonald-McGinn, D. M., & Sullivan, K. E. (2011). Chromosome 22q11. 2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). Medicine, 90(1), 1–18.CrossRefPubMed
McEwen, B. S. (1998). Stress, adaptation, and disease: Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840(1), 33–44.CrossRefPubMed
McLaughlin, K. A., Rith-Najarian, L., Dirks, M. A., & Sheridan, M. A. (2015). Low vagal tone magnifies the association between psychosocial stress exposure and internalizing psychopathology in adolescents. Journal of Clinical Child and Adolescent Psychology, 44(2), 314–328. doi:10.​1080/​15374416.​2013.​843464.CrossRefPubMed
Miller, G. E., Chen, E., & Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological bulletin, 133(1), 25.CrossRefPubMed
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: A latent variable analysis. Cognitive Psychology, 41(1), 49–100.CrossRefPubMed
Montojo, C. A., Ibrahim, A., Karlsgodt, K. H., Chow, C., Hilton, A., Jonas, R. K., ... Bearden, C (2014). Disrupted working memory circuitry and psychotic symptoms in 22q11. 2 deletion syndrome. NeuroImage: Clinical, 4, 392–402.CrossRef
Moss, E. M., Batshaw, M. L., Solot, C. B., Gerdes, M., McDonald-McGinn, D. M., Driscoll, D. A., ... Wang, & P, P. (1999). Psychoeducational profile of the 22q11. 2 microdeletion: A complex pattern. The Journal of Pediatrics, 134(2), 193–198.CrossRefPubMed
MTA Cooperative Group. (1999). A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 56(12), 1073–1086.CrossRef
Niklasson, L., Rasmussen, P., Óskarsdóttir, S., & Gillberg, C. (2009). Autism, ADHD, mental retardation and behavior problems in 100 individuals with 22q11 deletion syndrome. Research in Developmental Disabilities, 30(4), 763–773.CrossRefPubMed
Obradović, J., Bush, N. R., & Boyce, W. T. (2011). The interactive effect of marital conflict and stress reactivity on externalizing and internalizing symptoms: The role of laboratory stressors. Development and Psychopathology, 23(01), 101–114.CrossRefPubMed
Pacheco-Unguetti, A. P., Acosta, A., Callejas, A., & Lupiáñez, J. (2010). Attention and anxiety different attentional functioning under state and trait anxiety. Psychological science, 21(2), 298–304.CrossRefPubMed
Porges, S. W., Doussard-Roosevelt, J. A., Portales, A. L., & Greenspan, S. I. (1996). Infant regulation of the vagal “brake” predicts child behavior problems: A psychobiological model of social behavior. Developmental psychobiology, 29(8), 697–712.CrossRefPubMed
Porges, S. W., & Raskin, D. C. (1969). Respiratory and heart rate components of attention. Journal of Experimental Psychology, 81(3), 497.CrossRefPubMed
Pruessner, M., Béchard-Evans, L., Boekestyn, L., Iyer, S. N., Pruessner, J. C., & Malla, A. K. (2013). Attenuated cortisol response to acute psychosocial stress in individuals at ultra-high risk for psychosis. Schizophrenia Research, 146(1–3), 79–86.CrossRefPubMed
Robert, G., & Hockey, J. (1997). Compensatory control in the regulation of human performance under stress and high workload: A cognitive-energetical framework. Biological Psychology, 45(1), 73–93.CrossRef
Roozendaal, B. (2002). Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval. Neurobiology of Learning and Memory, 78(3), 578–595.CrossRefPubMed
Rottenberg, J., Salomon, K., Gross, J. J., & Gotlib, I. H. (2005). Vagal withdrawal to a sad film predicts subsequent recovery from depression. Psychophysiology, 42(3), 277–281.CrossRefPubMed
Rottenberg, J., Wilhelm, F. H., Gross, J. J., & Gotlib, I. H. (2002). Respiratory sinus arrhythmia as a predictor of outcome in major depressive disorder. Journal of Affective Disorders, 71(1), 265–272.CrossRefPubMed
Ruttle, P. L., Shirtcliff, E. A., Serbin, L. A., Fisher, D. B. D., Stack, D. M., & Schwartzman, A. E. (2011). Disentangling psychobiological mechanisms underlying internalizing and externalizing behaviors in youth: Longitudinal and concurrent associations with cortisol. Hormones and Behavior, 59(1), 123–132.CrossRefPubMed
Schneider, M., Van der Linden, M., Menghetti, S., Glaser, B., Debbané, M., & Eliez, S. (2014). Predominant negative symptoms in 22q11. 2 deletion syndrome and their associations with cognitive functioning and functional outcome. Journal of Psychiatric Research, 48(1), 86–93.CrossRefPubMed
Scott, B. G., & Weems, C. F. (2014). Resting vagal tone and vagal response to stress: associations with anxiety, aggression, and perceived anxiety control among youths. Psychophysiology, 51(8), 718–727.CrossRefPubMedPubMedCentral
Shackman, A. J., Sarinopoulos, I., Maxwell, J. S., Pizzagalli, D. A., Lavric, A., & Davidson, R. J. (2006). Anxiety selectively disrupts visuospatial working memory. Emotion, 6(1), 40.CrossRefPubMed
Shapiro, H. M., Takarae, Y., Harvey, D. J., Cabaral, M. H., & Simon, T. J. (2012). A cross-sectional study of the development of volitional control of spatial attention in children with chromosome 22q11. 2 deletion syndrome. Journal of Neurodevelopmental Disorders, 4(1), 1.CrossRef
Shashi, V., Veerapandiyan, A., Schoch, K., Kwapil, T., Keshavan, M., Ip, E., & Hooper, S. (2012). Social skills and associated psychopathology in children with chromosome 22q11. 2 deletion syndrome: implications for interventions. Journal of Intellectual Disability Research, 56(9), 865–878.CrossRefPubMed
Shrout, P. E., & Bolger, N. (2002). Mediation in experimental and nonexperimental studies: new procedures and recommendations. Psychological Methods, 7(4), 422.CrossRefPubMed
Simon, T. J., Bearden, C. E., Mc-Ginn, D. M., & Zackai, E. (2005). Visuospatial and numerical cognitive deficits in children with chromosome 22Q11.2 deletion syndrome. Cortex, 41(2), 145–155.CrossRefPubMedPubMedCentral
Simon, T. J., Bearden, C. E., Moss, E. M., McDonald-McGinn, D., Zackai, E., & Wang, P. P. (2002). Cognitive development in VCFS. Progress in Pediatric Cardiology, 15(2), 109–117.CrossRef
Simon, T. J., Wu, Z., Avants, B., Zhang, H., Gee, J. C., & Stebbins, G. T. (2008). Atypical cortical connectivity and visuospatial cognitive impairments are related in children with chromosome 22q11. 2 deletion syndrome. Behavioral and Brain Functions, 4(1), 1.CrossRef
Sobin, C., Kiley-Brabeck, K., Daniels, S., Khuri, J., Taylor, L., Blundell, M., ... & Karayiorgou, M. (2005). Neuropsychological characteristics of children with the 22q11 deletion syndrome: A descriptive analysis. Child Neuropsychology, 11(1), 39–53.CrossRefPubMedPubMedCentral
Sonntag, P., Gokalsing, E., Olivier, C., Robert, P., Burglen, F., Kauffmann-Muller, F., ... & Danion, J.-M. (2003). Impaired strategic regulation of contents of conscious awareness in schizophrenia. Consciousness and Cognition, 12(2), 190–200.CrossRefPubMed
Sorg, B. A., & Whitney, P. (1992). The effect of trait anxiety and situational stress on working memory capacity. Journal of Research in Personality, 26(3), 235–241.CrossRef
Starkman, M. N., Gebarski, S. S., Berent, S., & Schteingart, D. E. (1992). Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing’s syndrome. Biological Psychiatry, 32(9), 756–765.CrossRefPubMed
Stephenson, D. D., Beaton, E. A., Weems, C. F., Angkustsiri, K., & Simon, T. J. (2015). Identifying patterns of anxiety and depression in children with chromosome 22q11. 2 deletion syndrome: Comorbidity predicts behavioral difficulties and impaired functional communications. Behavioural Brain Research, 276, 190–198.CrossRefPubMed
Swanson, J. M. (1983). Swanson, nolan, and pelham questionnaire. Irvine, CA: University of California.
Swillen, A., Devriendt, K., Ghesquière, P., & Fryns, J.-P. (2000). Children with a 22q11 deletion versus children with a speech-language impairment and learning disability: behavior during primary school age. Genetic counseling, 12(4), 309–317.
Swillen, A., Devriendt, K., Legius, E., Eyskens, B., Dumoulin, M., Gewillig, M., & Fryns, J.-P. (1997). Intelligence and psychosocial adjustment in velocardiofacial syndrome: a study of 37 children and adolescents with VCFS. Journal of Medical Genetics, 34(6), 453–458.CrossRefPubMedPubMedCentral
Takahashi, T., Ikeda, K., Ishikawa, M., Kitamura, N., Tsukasaki, T., Nakama, D., & Kameda, T. (2005). Anxiety, reactivity, and social stress-induced cortisol elevation in humans. Neuroendocrinology Letters, 26(4), 351–354.PubMed
van Eck, M., Berkhof, H., Nicolson, N., & Sulon, J. (1996). The effects of perceived stress, traits, mood states, and stressful daily events on salivary cortisol. Psychosomatic Medicine, 58(5), 447–458.CrossRefPubMed
Vedhara, K., Hyde, J., Gilchrist, I., Tytherleigh, M., & Plummer, S. (2000). Acute stress, memory, attention and cortisol. Psychoneuroendocrinology, 25(6), 535–549.CrossRefPubMed
Wechsler, D. (2003). Wechsler intelligence scale for children-WISC-IV. Psychological corporation.
Wheeler, M. A., Stuss, D. T., & Tulving, E. (1997). Toward a theory of episodic memory: the frontal lobes and autonoetic consciousness. Psychological Bulletin, 121(3), 331.CrossRefPubMed
Woodin, M., Wang, P. P., Aleman, D., McDonald-McGinn, D., Zackai, E., & Moss, E. (2001). Neuropsychological profile of children and adolescents with the 22q11. 2 microdeletion. Genetics in Medicine, 3(1), 34–39.CrossRefPubMed
Wright, C. A., Dobson, K. S., & Sears, C. R. (2014). Does a high working memory capacity attenuate the negative impact of trait anxiety on attentional control? Evidence from the antisaccade task. Journal of Cognitive Psychology, 26(4), 400–412.CrossRef
Metagegevens
Titel
Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology
Auteurs
Ashley F. P. Sanders
Diana A. Hobbs
David D. Stephenson Jr.
Robert D. Laird
Elliott A. Beaton
Publicatiedatum
12-01-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-016-3011-2

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