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Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2017

30-01-2017 | Original Paper

Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis

Auteurs: Amene Saghazadeh, Nima Rezaei

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2017

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Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity. Altered blood BDNF levels have been frequently identified in people with autism spectrum disorders (ASD). There are however wide discrepancies in the evidence. Therefore, we performed the present systematic review and meta-analysis aimed at qualitative and quantitative synthesis of studies that measured blood BDNF levels in ASD and control subjects. Observational studies were identified through electronic database searching and also hand-searching of reference lists of relevant articles. A total of 183 papers were initially identified for review and eventually twenty studies were included in the meta-analysis. A meta-analysis of blood BDNF in 887 patients with ASD and 901 control subjects demonstrated significantly higher BDNF levels in ASD compared to controls with the SMD of 0.47 (95% CI 0.07–0.86, p = 0.02). In addition subgroup meta-analyses were performed based on the BDNF specimen. The present meta-analysis study led to conclusion that BDNF might play role in autism initiation/ propagation and therefore it can be considered as a possible biomarker of ASD.
Literatuur
go back to reference Abdallah, M. W., Mortensen, E. L., Greaves-Lord, K., Larsen, N., Bonefeld-Jorgensen, E. C., Norgaard-Pedersen, B., & Grove, J. (2013). Neonatal levels of neurotrophic factors and risk of autism spectrum disorders. Acta Psychiatrica Scandinavica, 128(1), 61–69. doi: 10.​1111/​acps.​12020. CrossRefPubMed Abdallah, M. W., Mortensen, E. L., Greaves-Lord, K., Larsen, N., Bonefeld-Jorgensen, E. C., Norgaard-Pedersen, B., & Grove, J. (2013). Neonatal levels of neurotrophic factors and risk of autism spectrum disorders. Acta Psychiatrica Scandinavica, 128(1), 61–69. doi: 10.​1111/​acps.​12020. CrossRefPubMed
go back to reference Abdallah, M. W., Pearce, B. D., Larsen, N., Greaves-Lord, K., Norgaard-Pedersen, B., Hougaard, D. M., & Grove, J. (2012). Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study. Autism Research, 5(6), 428–433. doi: 10.​1002/​aur.​1254. CrossRefPubMed Abdallah, M. W., Pearce, B. D., Larsen, N., Greaves-Lord, K., Norgaard-Pedersen, B., Hougaard, D. M., & Grove, J. (2012). Amniotic fluid MMP-9 and neurotrophins in autism spectrum disorders: an exploratory study. Autism Research, 5(6), 428–433. doi: 10.​1002/​aur.​1254. CrossRefPubMed
go back to reference Bailey, A. R., Giunta, B. N., Obregon, D., Nikolic, W. V., Tian, J., Sanberg, C. D., & Tan, J. (2008). Peripheral biomarkers in Autism: Secreted amyloid precursor protein-alpha as a probable key player in early diagnosis. International Journal of Clinical and Experimental Medicine, 1(4), 338–344. PubMedPubMedCentral Bailey, A. R., Giunta, B. N., Obregon, D., Nikolic, W. V., Tian, J., Sanberg, C. D., & Tan, J. (2008). Peripheral biomarkers in Autism: Secreted amyloid precursor protein-alpha as a probable key player in early diagnosis. International Journal of Clinical and Experimental Medicine, 1(4), 338–344. PubMedPubMedCentral
go back to reference Baio, J. (2012). Prevalence of autism spectrum disorders: Autism and developmental disabilities monitoring network, 14 sites, United States, 2008. Morbidity and mortality weekly report. Surveillance summaries (Vol. 61). Centers for Disease Control and Prevention. Baio, J. (2012). Prevalence of autism spectrum disorders: Autism and developmental disabilities monitoring network, 14 sites, United States, 2008. Morbidity and mortality weekly report. Surveillance summaries (Vol. 61). Centers for Disease Control and Prevention.
go back to reference Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind”? Cognition, 21(1), 37–46. CrossRefPubMed Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind”? Cognition, 21(1), 37–46. CrossRefPubMed
go back to reference Bauman, M. L., & Kemper, T. L. (2005). Neuroanatomic observations of the brain in autism: A review and future directions. International Journal of Developmental Neuroscience, 23(2), 183–187. CrossRefPubMed Bauman, M. L., & Kemper, T. L. (2005). Neuroanatomic observations of the brain in autism: A review and future directions. International Journal of Developmental Neuroscience, 23(2), 183–187. CrossRefPubMed
go back to reference Coghlan, S., Horder, J., Inkster, B., Mendez, M. A., Murphy, D. G., & Nutt, D. J. (2012). GABA system dysfunction in autism and related disorders: From synapse to symptoms. Neuroscience & Biobehavioral Reviews, 36(9), 2044–2055. CrossRef Coghlan, S., Horder, J., Inkster, B., Mendez, M. A., Murphy, D. G., & Nutt, D. J. (2012). GABA system dysfunction in autism and related disorders: From synapse to symptoms. Neuroscience & Biobehavioral Reviews, 36(9), 2044–2055. CrossRef
go back to reference Connolly, A. M., Chez, M., Streif, E. M., Keeling, R. M., Golumbek, P. T., Kwon, J. M., & Deuel, R. M. (2006). Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau–Kleffner syndrome, and epilepsy. Biological Psychiatry, 59(4), 354–363. doi: 10.​1016/​j.​biopsych.​2005.​07.​004. CrossRefPubMed Connolly, A. M., Chez, M., Streif, E. M., Keeling, R. M., Golumbek, P. T., Kwon, J. M., & Deuel, R. M. (2006). Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau–Kleffner syndrome, and epilepsy. Biological Psychiatry, 59(4), 354–363. doi: 10.​1016/​j.​biopsych.​2005.​07.​004. CrossRefPubMed
go back to reference Correia, C. T., Coutinho, A. M., Sequeira, A. F., Sousa, I. G., Lourenco Venda, L., Almeida, J. P., & Vicente, A. M. (2010). Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. The Journal of Neuroscience, 9(7), 841–848. doi: 10.​1111/​j1601183X.​2010.​00627.​x. Correia, C. T., Coutinho, A. M., Sequeira, A. F., Sousa, I. G., Lourenco Venda, L., Almeida, J. P., & Vicente, A. M. (2010). Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. The Journal of Neuroscience, 9(7), 841–848. doi: 10.​1111/​j1601183X.​2010.​00627.​x.
go back to reference Croen, L. A., Goines, P., Braunschweig, D., Yolken, R., Yoshida, C. K., Grether, J. K., & Van de Water, J. (2008). Brain-derived neurotrophic factor and autism: Maternal and infant peripheral blood levels in the early markers for autism (EMA) study. Autism Research, 1(2), 130–137. doi: 10.​1002/​aur.​14. CrossRefPubMedPubMedCentral Croen, L. A., Goines, P., Braunschweig, D., Yolken, R., Yoshida, C. K., Grether, J. K., & Van de Water, J. (2008). Brain-derived neurotrophic factor and autism: Maternal and infant peripheral blood levels in the early markers for autism (EMA) study. Autism Research, 1(2), 130–137. doi: 10.​1002/​aur.​14. CrossRefPubMedPubMedCentral
go back to reference De Rubeis, S., He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Cicek, A. E., & Walker, S. (2014). Synaptic, transcriptional and chromatin genes disrupted in autism. Nature, 515(7526), 209–215. CrossRefPubMedPubMedCentral De Rubeis, S., He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Cicek, A. E., & Walker, S. (2014). Synaptic, transcriptional and chromatin genes disrupted in autism. Nature, 515(7526), 209–215. CrossRefPubMedPubMedCentral
go back to reference Enstrom, A., Onore, C., Tarver, A., Hertz-Picciotto, I., Hansen, R., Croen, L., & Ashwood, P. (2008). Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism. American Journal of Biochemistry and Biotechnology, 4(2), 121–129. CrossRefPubMedPubMedCentral Enstrom, A., Onore, C., Tarver, A., Hertz-Picciotto, I., Hansen, R., Croen, L., & Ashwood, P. (2008). Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism. American Journal of Biochemistry and Biotechnology, 4(2), 121–129. CrossRefPubMedPubMedCentral
go back to reference Ernfors, P., Lee, K. -F., & Jaenisch, R. (1994). Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature, 368, 147–150. CrossRefPubMed Ernfors, P., Lee, K. -F., & Jaenisch, R. (1994). Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature, 368, 147–150. CrossRefPubMed
go back to reference Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002). Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. Journal of Neurophysiology, 88(5), 2187–2195. CrossRefPubMed Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002). Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. Journal of Neurophysiology, 88(5), 2187–2195. CrossRefPubMed
go back to reference Halepoto, D. M., Bashir, S., & Al-Ayadhi, L. (2014). Possible role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder: Current status. Journal of the College of Physicians and Surgeons Pakistan, 24(4), 274–278. PubMed Halepoto, D. M., Bashir, S., & Al-Ayadhi, L. (2014). Possible role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder: Current status. Journal of the College of Physicians and Surgeons Pakistan, 24(4), 274–278. PubMed
go back to reference Halepoto, D. M., Bashir, S., Zeina, R., & Al-Ayadhi, L. Y. (2015). Correlation between hedgehog (Hh) protein family and brain-derived neurotrophic factor (BDNF) in autism spectrum disorder (ASD). Journal of the College of Physicians and Surgeons Pakistan, 25(12), 882–885. PubMed Halepoto, D. M., Bashir, S., Zeina, R., & Al-Ayadhi, L. Y. (2015). Correlation between hedgehog (Hh) protein family and brain-derived neurotrophic factor (BDNF) in autism spectrum disorder (ASD). Journal of the College of Physicians and Surgeons Pakistan, 25(12), 882–885. PubMed
go back to reference Han, J. C., Thurm, A., Golden Williams, C., Joseph, L. A., Zein, W. M., Brooks, B. P., & Swedo, S. E. (2013). Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome. Cortex, 49(10), 2700–2710. doi: 10.​1016/​j.​cortex.​2013.​02.​009. CrossRefPubMed Han, J. C., Thurm, A., Golden Williams, C., Joseph, L. A., Zein, W. M., Brooks, B. P., & Swedo, S. E. (2013). Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome. Cortex, 49(10), 2700–2710. doi: 10.​1016/​j.​cortex.​2013.​02.​009. CrossRefPubMed
go back to reference Happe, F., Ehlers, S., Fletcher, P., Frith, U., Johansson, M., Gillberg, C., & Frith, C. (1996). Theory of mind in the brain. Evidence from a PET scan study of Asperger syndrome. Neuroreport, 8(1), 197–201. CrossRefPubMed Happe, F., Ehlers, S., Fletcher, P., Frith, U., Johansson, M., Gillberg, C., & Frith, C. (1996). Theory of mind in the brain. Evidence from a PET scan study of Asperger syndrome. Neuroreport, 8(1), 197–201. CrossRefPubMed
go back to reference Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., & Mori, N. (2006). Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(8), 1529–1531. doi: 10.​1016/​j.​pnpbp.​2006.​06.​018. CrossRef Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., & Mori, N. (2006). Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(8), 1529–1531. doi: 10.​1016/​j.​pnpbp.​2006.​06.​018. CrossRef
go back to reference Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B., Roberts, J., & Mirrett, P. (2006). Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics Part A, 140(17), 1804–1813. CrossRef Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B., Roberts, J., & Mirrett, P. (2006). Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics Part A, 140(17), 1804–1813. CrossRef
go back to reference Katoh-Semba, R., Wakako, R., Komori, T., Shigemi, H., Miyazaki, N., Ito, H., & Nakayama, A. (2007). Age-related changes in BDNF protein levels in human serum: Differences between autism cases and normal controls. International Journal of Developmental Neuroscience, 25(6), 367–372. doi: 10.​1016/​j.​ijdevneu.​2007.​07.​002. CrossRefPubMed Katoh-Semba, R., Wakako, R., Komori, T., Shigemi, H., Miyazaki, N., Ito, H., & Nakayama, A. (2007). Age-related changes in BDNF protein levels in human serum: Differences between autism cases and normal controls. International Journal of Developmental Neuroscience, 25(6), 367–372. doi: 10.​1016/​j.​ijdevneu.​2007.​07.​002. CrossRefPubMed
go back to reference Kelleher, R. J., & Bear, M. F. (2008). The autistic neuron: Troubled translation? Cell, 135(3), 401–406. CrossRefPubMed Kelleher, R. J., & Bear, M. F. (2008). The autistic neuron: Troubled translation? Cell, 135(3), 401–406. CrossRefPubMed
go back to reference Kim, J. A., Szatmari, P., Bryson, S. E., Streiner, D. L., & Wilson, F. J. (2000). The prevalence of anxiety and mood problems among children with autism and Asperger syndrome. Autism: The International Journal of Research and Practice, 4(2), 117–132. CrossRef Kim, J. A., Szatmari, P., Bryson, S. E., Streiner, D. L., & Wilson, F. J. (2000). The prevalence of anxiety and mood problems among children with autism and Asperger syndrome. Autism: The International Journal of Research and Practice, 4(2), 117–132. CrossRef
go back to reference Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences USA, 92(19), 8856–8860. CrossRef Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995). Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proceedings of the National Academy of Sciences USA, 92(19), 8856–8860. CrossRef
go back to reference Lavelle, T. A., Weinstein, M. C., Newhouse, J. P., Munir, K., Kuhlthau, K. A., & Prosser, L. A. (2014). Economic burden of childhood autism spectrum disorders. Pediatrics, 133(3), e520–e529. CrossRefPubMed Lavelle, T. A., Weinstein, M. C., Newhouse, J. P., Munir, K., Kuhlthau, K. A., & Prosser, L. A. (2014). Economic burden of childhood autism spectrum disorders. Pediatrics, 133(3), e520–e529. CrossRefPubMed
go back to reference Lee, L.-C., Harrington, R. A., Louie, B. B., & Newschaffer, C. J. (2008). Children with autism: Quality of life and parental concerns. Journal of Autism and Developmental Disorders, 38(6), 1147–1160. CrossRefPubMed Lee, L.-C., Harrington, R. A., Louie, B. B., & Newschaffer, C. J. (2008). Children with autism: Quality of life and parental concerns. Journal of Autism and Developmental Disorders, 38(6), 1147–1160. CrossRefPubMed
go back to reference Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Barde, Y. -A. (1989). Molecular cloning and expression of brain-derived neurotrophic factor. Nature, 341, 149–152. CrossRefPubMed Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Barde, Y. -A. (1989). Molecular cloning and expression of brain-derived neurotrophic factor. Nature, 341, 149–152. CrossRefPubMed
go back to reference Lu, B. (2003). BDNF and activity-dependent synaptic modulation. Learning & Memory, 10(2), 86–98. CrossRef Lu, B. (2003). BDNF and activity-dependent synaptic modulation. Learning & Memory, 10(2), 86–98. CrossRef
go back to reference Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., & Sun, Y. E. (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science, 302(5646), 890–893. CrossRefPubMed Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., & Sun, Y. E. (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science, 302(5646), 890–893. CrossRefPubMed
go back to reference Meng, W. D., Sun, S. J., Yang, J., Chu, R. X., Tu, W., & Liu, Q. (2016). Elevated serum brain-derived neurotrophic factor (BDNF) but not BDNF gene Val66Met polymorphism is associated with autism spectrum disorders. Molecular Neurobiology. doi: 10.​1007/​s12035-016-9721-9. Meng, W. D., Sun, S. J., Yang, J., Chu, R. X., Tu, W., & Liu, Q. (2016). Elevated serum brain-derived neurotrophic factor (BDNF) but not BDNF gene Val66Met polymorphism is associated with autism spectrum disorders. Molecular Neurobiology. doi: 10.​1007/​s12035-016-9721-9.
go back to reference Miyazaki, K., Narita, N., Sakuta, R., Miyahara, T., Naruse, H., Okado, N., & Narita, M. (2004). Serum neurotrophin concentrations in autism and mental retardation: A pilot study. Brain & Development, 26(5), 292–295. doi: 10.​1016/​s0387-7604(03)00168-2. CrossRef Miyazaki, K., Narita, N., Sakuta, R., Miyahara, T., Naruse, H., Okado, N., & Narita, M. (2004). Serum neurotrophin concentrations in autism and mental retardation: A pilot study. Brain & Development, 26(5), 292–295. doi: 10.​1016/​s0387-7604(03)00168-2. CrossRef
go back to reference Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., & Conner, J. M. (2009). Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease. Nature Medicine, 15(3), 331–337. CrossRefPubMedPubMedCentral Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., & Conner, J. M. (2009). Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer’s disease. Nature Medicine, 15(3), 331–337. CrossRefPubMedPubMedCentral
go back to reference Nelson, K. B., Grether, J. K., Croen, L. A., Dambrosia, J. M., Dickens, B. F., Jelliffe, L. L., & Phillips, T. M. (2001). Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Annals of Neurology, 49(5), 597–606. CrossRefPubMed Nelson, K. B., Grether, J. K., Croen, L. A., Dambrosia, J. M., Dickens, B. F., Jelliffe, L. L., & Phillips, T. M. (2001). Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Annals of Neurology, 49(5), 597–606. CrossRefPubMed
go back to reference Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S., Satyanarayana, G., & Nelson, K. B. (2006). Selected neurotrophins, neuropeptides, and cytokines: Developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. International Journal of Developmental Neuroscience, 24(1), 73–80. doi: 10.​1016/​j.​ijdevneu.​2005.​10.​003. CrossRefPubMed Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S., Satyanarayana, G., & Nelson, K. B. (2006). Selected neurotrophins, neuropeptides, and cytokines: Developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. International Journal of Developmental Neuroscience, 24(1), 73–80. doi: 10.​1016/​j.​ijdevneu.​2005.​10.​003. CrossRefPubMed
go back to reference Rodrigues, D. H., Rocha, N. P., Sousa, L. F., Barbosa, I. G., Kummer, A., & Teixeira, A. L. (2014). Circulating levels of neurotrophic factors in autism spectrum disorders. Neuro Endocrinology Letters, 35(5), 380–384. PubMed Rodrigues, D. H., Rocha, N. P., Sousa, L. F., Barbosa, I. G., Kummer, A., & Teixeira, A. L. (2014). Circulating levels of neurotrophic factors in autism spectrum disorders. Neuro Endocrinology Letters, 35(5), 380–384. PubMed
go back to reference Segura, M., Pedreno, C., Obiols, J., Taurines, R., Pamias, M., Grunblatt, E., & Gella, A. (2015). Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. Neurogenetics, 16(2), 123–131. doi: 10.​1007/​s10048-014-0434-9. CrossRefPubMed Segura, M., Pedreno, C., Obiols, J., Taurines, R., Pamias, M., Grunblatt, E., & Gella, A. (2015). Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. Neurogenetics, 16(2), 123–131. doi: 10.​1007/​s10048-014-0434-9. CrossRefPubMed
go back to reference Sheikh, A. M., Malik, M., Wen, G., Chauhan, A., Chauhan, V., Gong, C. X., & Li, X. (2010). BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. Journal of Neuroscience Research, 88(12), 2641–2647. doi: 10.​1002/​jnr.​22416. PubMed Sheikh, A. M., Malik, M., Wen, G., Chauhan, A., Chauhan, V., Gong, C. X., & Li, X. (2010). BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. Journal of Neuroscience Research, 88(12), 2641–2647. doi: 10.​1002/​jnr.​22416. PubMed
go back to reference Shirayama, Y., Chen, A. C. H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. The Journal of Neuroscience, 22(8), 3251–3261. PubMed Shirayama, Y., Chen, A. C. H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. The Journal of Neuroscience, 22(8), 3251–3261. PubMed
go back to reference Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47(8), 921–929. CrossRef Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47(8), 921–929. CrossRef
go back to reference Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997). Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacology Biochemistry and Behavior, 56(1), 131–137. CrossRef Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997). Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacology Biochemistry and Behavior, 56(1), 131–137. CrossRef
go back to reference Sokol, D. K., Chen, D., Farlow, M. R., Dunn, D. W., Maloney, B., Zimmer, J. A., & Lahiri, D. K. (2006). High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. Journal of Child Neurology, 21(6), 444–449. CrossRefPubMed Sokol, D. K., Chen, D., Farlow, M. R., Dunn, D. W., Maloney, B., Zimmer, J. A., & Lahiri, D. K. (2006). High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. Journal of Child Neurology, 21(6), 444–449. CrossRefPubMed
go back to reference Spratt, E. G., Granholm, A. C., Carpenter, L. A., Boger, H. A., Papa, C. E., Logan, S., & Brady, K. T. (2015). Pilot study and review: Physiological differences in BDNF, a potential biomarker in males and females with autistic disorder. International Neuropsychiatric Disease Journal, 3(1), 19–26. doi: 10.​9734/​indj/​2015/​12118. CrossRefPubMed Spratt, E. G., Granholm, A. C., Carpenter, L. A., Boger, H. A., Papa, C. E., Logan, S., & Brady, K. T. (2015). Pilot study and review: Physiological differences in BDNF, a potential biomarker in males and females with autistic disorder. International Neuropsychiatric Disease Journal, 3(1), 19–26. doi: 10.​9734/​indj/​2015/​12118. CrossRefPubMed
go back to reference Stahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004). Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. Journal of Neural Transmission, 111(7), 891–902. doi: 10.​1007/​s00702-004-0115-1. CrossRefPubMed Stahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004). Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. Journal of Neural Transmission, 111(7), 891–902. doi: 10.​1007/​s00702-004-0115-1. CrossRefPubMed
go back to reference Taurines, R., Segura, M., Schecklmann, M., Albantakis, L., Grunblatt, E., Walitza, S., & Gerlach, M. (2014). Altered peripheral BDNF mRNA expression and BDNF protein concentrations in blood of children and adolescents with autism spectrum disorder. Journal of Neural Transmission, 121(9), 1117–1128. doi: 10.​1007/​s00702-014-1162-x. CrossRefPubMed Taurines, R., Segura, M., Schecklmann, M., Albantakis, L., Grunblatt, E., Walitza, S., & Gerlach, M. (2014). Altered peripheral BDNF mRNA expression and BDNF protein concentrations in blood of children and adolescents with autism spectrum disorder. Journal of Neural Transmission, 121(9), 1117–1128. doi: 10.​1007/​s00702-014-1162-x. CrossRefPubMed
go back to reference Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European Journal of Neuroscience, 20(10), 2580–2590. CrossRefPubMed Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European Journal of Neuroscience, 20(10), 2580–2590. CrossRefPubMed
go back to reference Wells, G. A., Shea, B., O’connell, D., Peterson, J. E., Welch, V., Losos, M., & Tugwell, P. (2000). The Newcastle–Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Wells, G. A., Shea, B., O’connell, D., Peterson, J. E., Welch, V., Losos, M., & Tugwell, P. (2000). The Newcastle–Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
go back to reference White, S. W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29(3), 216–229. CrossRefPubMedPubMedCentral White, S. W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29(3), 216–229. CrossRefPubMedPubMedCentral
go back to reference Wink, L. K., Fitzpatrick, S., Shaffer, R., Melnyk, S., Begtrup, A. H., Fox, E., & Erickson, C. A. (2015). The neurobehavioral and molecular phenotype of Angelman syndrome. American Journal of Medical Genetics Part A, 167(11), 2623–2628. doi: 10.​1002/​ajmg.​a.​37254. CrossRef Wink, L. K., Fitzpatrick, S., Shaffer, R., Melnyk, S., Begtrup, A. H., Fox, E., & Erickson, C. A. (2015). The neurobehavioral and molecular phenotype of Angelman syndrome. American Journal of Medical Genetics Part A, 167(11), 2623–2628. doi: 10.​1002/​ajmg.​a.​37254. CrossRef
go back to reference Zoghbi, H. Y. (2003). Postnatal neurodevelopmental disorders: Meeting at the synapse? Science, 302(5646), 826–830. CrossRefPubMed Zoghbi, H. Y. (2003). Postnatal neurodevelopmental disorders: Meeting at the synapse? Science, 302(5646), 826–830. CrossRefPubMed
go back to reference Zuccato, C., & Cattaneo, E. (2009). Brain-derived neurotrophic factor in neurodegenerative diseases. Nature Reviews Neurology, 5(6), 311–322. CrossRefPubMed Zuccato, C., & Cattaneo, E. (2009). Brain-derived neurotrophic factor in neurodegenerative diseases. Nature Reviews Neurology, 5(6), 311–322. CrossRefPubMed
Metagegevens
Titel
Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis
Auteurs
Amene Saghazadeh
Nima Rezaei
Publicatiedatum
30-01-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-016-3024-x