Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in:

03-02-2017 | Original Paper

Quantitative Sensory Testing in adults with Autism Spectrum Disorders

Auteurs: Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker, Nicole David, Andreas K. Engel, Katarina Forkmann, Nathalie Wrobel, Alexander Münchau, Ulrike Bingel

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2017

Abstract

Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds. Two ASD patients showed paradoxical heat sensations and another two ASD subjects presented dynamic mechanical allodynia; somatosensory features that were absent in controls. These findings suggest that central mechanisms during complex stimulus integration rather than peripheral dysfunctions probably determine somatosensory alterations in ASD.

vorige artikel Emotion Perception Mediates the Predictive Relationship Between Verbal Ability and Functional Outcome in High-Functioning Adults with Autism Spectrum Disorder

volgende artikel A Retrospective Video Analysis of Canonical Babbling and Volubility in Infants with Fragile X Syndrome at 9–12 Months of Age

Alleen toegankelijk voor geautoriseerde gebruikers

American Psychiatric Association, A. (2000). Diagnostic and statistical manual of mental disorders Dsm-IV-Tr (Text Revision) (4th ed.). Washington, DC: American Psychiatric Press Inc.

APA (2013). Diagnostic and statistical manual of mental disorders (DSM-5(r)).

Baron, R., & Saguer, M. (1995). Mechanical allodynia in postherpetic neuralgia: evidence for central mechanisms depending on nociceptive C-fiber degeneration. Neurology, 45(12 Suppl 8), S63–65. CrossRefPubMed

Baron-Cohen, S., Ashwin, E., Ashwin, C., Tavassoli, T., & Chakrabarti, B. (2009). Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 364(1522), 1377–1383. doi: 10.1098/rstb.2008.0337. CrossRefPubMedPubMedCentral

Baron-Cohen, S., Hoekstra, R. A., Knickmeyer, R., & Wheelwright, S. (2006). The autism-spectrum quotient (AQ)–adolescent version. Journal of Autism and Developmental Disorders, 36(3), 343–350. doi: 10.1007/s10803-006-0073-6. CrossRefPubMed

Baron-Cohen, S., Richler, J., Bisarya, D., Gurunathan, N., & Wheelwright, S. (2003). The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358(1430), 361–374. doi: 10.1098/rstb.2002.1206. CrossRefPubMedPubMedCentral

Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34(2), 163–175. CrossRefPubMed

Baum, S. H., Stevenson, R. A., & Wallace, M. T. (2015). Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder. Progress in Neurobiology, 134, 140–160. doi: 10.1016/j.pneurobio.2015.09.007. CrossRefPubMedPubMedCentral

Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571. CrossRefPubMed

Bertone, A., Mottron, L., Jelenic, P., & Faubert, J. (2003). Motion perception in autism: A “complex” issue. Journal of Cognitive Neuroscience, 15(2), 218–225. doi: 10.1162/089892903321208150. CrossRefPubMed

Bird, G., Silani, G., Brindley, R., White, S., Frith, U., & Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain: A Journal of Neurology, 133(Pt 5), 1515–1525. doi: 10.1093/brain/awq060. CrossRef

Blakemore, S. J., Tavassoli, T., Calo, S., Thomas, R. M., Catmur, C., Frith, U., et al. (2006). Tactile sensitivity in asperger syndrome. Brain and Cognition, 61(1), 5–13. doi: 10.1016/j.bandc.2005.12.013. CrossRefPubMed

Cascio, C., McGlone, F., Folger, S., Tannan, V., Baranek, G., Pelphrey, K. A., et al. (2008). Tactile perception in adults with autism: A multidimensional psychophysical study. Journal of Autism and Developmental Disorders, 38(1), 127–137. doi: 10.1007/s10803-007-0370-8. CrossRefPubMed

Cesaroni, L., & Garber, M. (1991). Exploring the experience of autism through firsthand accounts. Journal of Autism and Developmental Disorders, 21(3), 303–313. CrossRefPubMed

Craig, A. D., & Bushnell, M. C. (1994). The thermal grill illusion: Unmasking the burn of cold pain. Science, 265(5169), 252–255. CrossRefPubMed

David, N., Schneider, T. R., Peiker, I., Al-Jawahiri, R., Engel, A. K., & Milne, E. (2016). Variability of cortical oscillation patterns: A possible endophenotype in autism spectrum disorders? Neuroscience and Biobehavioral Reviews, 71, 590–600. doi: 10.1016/j.neubiorev.2016.09.031. CrossRefPubMed

Davis, K. D., Pope, G. E., Crawley, A. P., & Mikulis, D. J. (2004). Perceptual illusion of “paradoxical heat” engages the insular cortex. Journal of Neurophysiology, 92(2), 1248–1251. doi: 10.1152/jn.00084.2004. CrossRefPubMed

Di Martino, A., Ross, K., Uddin, L. Q., Sklar, A. B., Castellanos, F. X., & Milham, M. P. (2009). Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis. Biological Psychiatry, 65(1), 63–74. doi: 10.1016/j.biopsych.2008.09.022. CrossRefPubMed

Duerden, E. G., Taylor, M. J., Lee, M., McGrath, P. A., Davis, K. D., & Roberts, W. (2015). Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. The Journal of Pain: Official Journal of the American Pain Society. doi: 10.1016/j.jpain.2015.02.001.

Elwin, M., Ek, L., Schroder, A., & Kjellin, L. (2012). Autobiographical accounts of sensing in Asperger syndrome and high-functioning autism. Archives of Psychiatric Nursing, 26(5), 420–429. doi: 10.1016/j.apnu.2011.10.003. CrossRefPubMed

Fan, Y. T., Chen, C., Chen, S. C., Decety, J., & Cheng, Y. (2014). Empathic arousal and social understanding in individuals with autism: Evidence from fMRI and ERP measurements. Social Cognitive and Affective Neuroscience, 9(8), 1203–1213. doi: 10.1093/scan/nst101. CrossRefPubMed

Gierthmühlen, J., & Baron, R. (2013). Vom Symptom zur Therapie. In R. Baron, W. Koppert, M. Strumpf & A. Willweber-Strumpf (Eds.), Praktische Schmerzmedizin - Interdisziplinäre Diagnostik - Multimodale Therapie (Vol. 3, pp. 67–79). Berlin Heidelberg: Springer-Verlag Berlin Heidelberg.

Grandin, T. (1995). Thinking in pictures; and other reports from my life with autism. New York: Double Day.

Grone, E., Crispin, A., Fleckenstein, J., Irnich, D., Treede, R. D., & Lang, P. M. (2012). Test order of quantitative sensory testing facilitates mechanical hyperalgesia in healthy volunteers. The Journal of Pain: Official Journal of the American Pain Society, 13(1), 73–80. doi: 10.1016/j.jpain.2011.10.005. CrossRef

Guclu, B., Tanidir, C., Mukaddes, N. M., & Unal, F. (2007). Tactile sensitivity of normal and autistic children. Somatosensory and Motor Research, 24(1–2), 21–33. doi: 10.1080/08990220601179418. CrossRefPubMed

Hoitsma, E., Reulen, J. P., de Baets, M., Drent, M., Spaans, F., & Faber, C. G. (2004). Small fiber neuropathy: a common and important clinical disorder. Journal of the Neurological Sciences, 227(1), 119–130. doi: 10.1016/j.jns.2004.08.012. CrossRefPubMed

Jensen, T. S., & Finnerup, N. B. (2014). Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. Lancet Neurology, 13(9), 924–935. doi: 10.1016/S1474-4422(14)70102-4. CrossRefPubMed

Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: a comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325. doi: 10.1007/s10803-012-1679-5. CrossRefPubMed

Kientz, M. A., & Dunn, W. (1997). A comparison of the performance of children with and without autism on the Sensory Profile. The American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association, 51(7), 530–537. CrossRef

Klauenberg, S., Maier, C., Assion, H. J., Hoffmann, A., Krumova, E. K., Magerl, W., et al. (2008). Depression and changed pain perception: Hints for a central disinhibition mechanism. Pain, 140(2), 332–343. doi: 10.1016/j.pain.2008.09.003. CrossRefPubMed

Lehrl, S. (2005). Mehrfachwach-Wortschatz-Intelligenztest MWT-B (5th edition ed.). Balingen: Spitta Verlag.

Magerl, W., & Klein, T. (2006). Experimental human models of neuropathic pain. In F. Cervero, & T. S. Jensen (Ed.), Handbook of clinical neurology (Vol. 81 Pain, pp. 503–516). Edinburgh: Elsevier.

Magerl, W., Krumova, E. K., Baron, R., Tolle, T., Treede, R. D., & Maier, C. (2010). Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data. Pain, 151(3), 598–605. doi: 10.1016/j.pain.2010.07.026. CrossRefPubMed

Marco, E. J., Hinkley, L. B., Hill, S. S., & Nagarajan, S. S. (2011). Sensory processing in autism: a review of neurophysiologic findings. Pediatric Research, 69(5 Pt 2), 48R–54R, doi: 10.1203/PDR.0b013e3182130c54. CrossRefPubMedPubMedCentral

Milne, E. (2011). Increased intra-participant variability in children with autistic spectrum disorders: evidence from single-trial analysis of evoked EEG. Front Psychol, 2, 51. doi: 10.3389/fpsyg.2011.00051. CrossRefPubMedPubMedCentral

Minshew, N., & Goldstein, G. (1998). Autism as a disorder of complex information processing. Mental Retardation and Developmental Disabilities Research Reviews, 4(2), 129–136. doi: 10.1002/(SICI)1098-2779(1998)4:2<129::AID-MRDD10>3.0.CO;2-X. CrossRef

Moore, D. J. (2015). Acute pain experience in individuals with autism spectrum disorders: A review. Autism: The International Journal of Research and Practice, 19(4), 387–399. doi: 10.1177/1362361314527839. CrossRef

Mucke, M., Cuhls, H., Radbruch, L., Baron, R., Maier, C., Tolle, T., et al. (2014). [Quantitative sensory testing]. Schmerz, 28(6), 635–646. doi: 10.1007/s00482-014-1485-4. CrossRefPubMed

O’Riordan, M., & Passetti, F. (2006). Discrimination in autism within different sensory modalities. Journal of Autism and Developmental Disorders, 36(5), 665–675. doi: 10.1007/s10803-006-0106-1. CrossRefPubMed

Puts, N. A., Wodka, E. L., Tommerdahl, M., Mostofsky, S. H., & Edden, R. A. (2014). Impaired tactile processing in children with autism spectrum disorder. Journal of Neurophysiology, 111(9), 1803–1811. doi: 10.1152/jn.00890.2013. CrossRefPubMedPubMedCentral

Riquelme, I., Hatem, S. M., & Montoya, P. (2016). Abnormal pressure pain, touch sensitivity, proprioception, and manual dexterity in children with autism spectrum disorders. Neural Plasticity, 2016, 1723401. doi: 10.1155/2016/1723401. CrossRefPubMedPubMedCentral

Rolke, R., Andrews, K., Magerl, W., & Treede, R. -D. (2010). Investigator’s Brochure: A standardized battery of quantitative sensory testing according to the protocol of the German Research Network on neuropathic pain (DFNS) - Version 2.1.

Rolke, R., Baron, R., Maier, C., Tolle, T. R., Treede, R. D., Beyer, A., et al. (2006). Quantitative sensory testing in the German research network on neuropathic pain (DFNS): standardized protocol and reference values. Pain, 123(3), 231–243. doi: 10.1016/j.pain.2006.01.041. CrossRefPubMed

Sandkuhler, J. (2009). Models and mechanisms of hyperalgesia and allodynia. Physiological Reviews, 89(2), 707–758. doi: 10.1152/physrev.00025.2008. CrossRefPubMed

Schneider, G., Pogatzki-Zahn, E., Marziniak, M., Stumpf, A., & Ständer, S. (2015). Cutaneous sensory function is not related to depression and anxiety in patients with chronic pruritus with dysesthetic subqualities. Acta Dermato Venereologica, 95, 289–293. CrossRefPubMed

Schunke, O., Grashorn, W., Kahl, U., Schottle, D., Haggard, P., Munchau, A., et al. (2016). Quantitative sensory testing in adults with tourette syndrome. Parkinsonism & Related Disorders, 24, 132–136. doi: 10.1016/j.parkreldis.2016.01.006. CrossRef

Siegel, D. J., Minshew, N. J., & Goldstein, G. (1996). Wechsler IQ profiles in diagnosis of high-functioning autism. Journal of Autism and Developmental Disorders, 26(4), 389–406. CrossRefPubMed

Silva, L. M., & Schalock, M. (2012). Sense and self-regulation checklist, a measure of comorbid autism symptoms: initial psychometric evidence. The American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association, 66(2), 177–186. doi: 10.5014/ajot.2012.001578. CrossRef

Silva, L. M., & Schalock, M. (2013). Prevalence and significance of abnormal tactile responses in young children with autism. North American Journal of Medicine and Science, 6 (No.3), 121–127.

Susser, E., Sprecher, E., & Yarnitsky, D. (1999). Paradoxical heat sensation in healthy subjects: Peripherally conducted by A delta or C fibres? Brain, 122 (Pt 2), 239–246. CrossRefPubMed

Tavassoli, T., Bellesheim, K., Tommerdahl, M., Holden, J. M., Kolevzon, A., & Buxbaum, J. D. (2015). Altered tactile processing in children with autism spectrum disorder. Autism Research. doi: 10.1002/aur.1563. PubMed

Tonacci, A., Billeci, L., Tartarisco, G., Ruta, L., Muratori, F., Pioggia, G., et al. (2017). [Formula: see text] Olfaction in autism spectrum disorders: A systematic review. Child neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence, 23(1), 1–25. doi: 10.1080/09297049.2015.1081678. CrossRef

Uddin, L. Q., & Menon, V. (2009). The anterior insula in autism: under-connected and under-examined. Neuroscience and Biobehavioral Reviews, 33(8), 1198–1203. doi: 10.1016/j.neubiorev.2009.06.002. CrossRefPubMedPubMedCentral

Wahren, L. K., Torebjork, E., & Jorum, E. (1989). Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain, 38(3), 313–319. CrossRefPubMed

Yasuda, Y., Hashimoto, R., Nakae, A., Kang, H., Ohi, K., Yamamori, H., et al. (2016). Sensory cognitive abnormalities of pain in autism spectrum disorder: A case–control study. Ann Gen Psychiatry, 15, 8. doi: 10.1186/s12991-016-0095-1. CrossRefPubMedPubMedCentral

Titel: Quantitative Sensory Testing in adults with Autism Spectrum Disorders
Auteurs: Odette Fründt
Wiebke Grashorn
Daniel Schöttle
Ina Peiker
Nicole David
Andreas K. Engel
Katarina Forkmann
Nathalie Wrobel
Alexander Münchau
Ulrike Bingel
Publicatiedatum: 03-02-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3041-4

Bohn Stafleu van Loghum

Tip

Swipe om te navigeren naar een ander artikel

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 4/2017

Do Handwriting Difficulties Correlate with Core Symptomology, Motor Proficiency and Attentional Behaviours?

Peabody Picture Vocabulary Test: Proxy for Verbal IQ in Genetic Studies of Autism Spectrum Disorder

The Experiences of Fathers Who Have Offspring with Autism Spectrum Disorder

Planning Skills in Autism Spectrum Disorder Across the Lifespan: A Meta-analysis and Meta-regression

Does the Presence of Anxiety and ADHD Symptoms Add to Social Impairment in Children with Autism Spectrum Disorder?

Health Care Transition Planning Among Adolescents with Autism Spectrum Disorder