Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2008

01-02-2008 | Original Paper

Are There Enhanced MBP Autoantibodies in Autism?

Auteurs: Jane E. Libbey, Hilary H. Coon, Nikki J. Kirkman, Thayne L. Sweeten, Judith N. Miller, Edward K. Stevenson, Janet E. Lainhart, William M. McMahon, Robert S. Fujinami

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2008

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism.
Literatuur
go back to reference Alexander, A. L., Lee, J. E., Lazar, M., Boudos, R., Dubray, M. B., Oakes, T. R., Miller, J. N., Lu, J., Jeong, E. K., McMahon, W. M., Bigler, E. D., & Lainhart, J. E. (2007). Diffusion tensor imaging of the corpus callosum in Autism. Neuroimage, 34, 61–73. PubMedCrossRef Alexander, A. L., Lee, J. E., Lazar, M., Boudos, R., Dubray, M. B., Oakes, T. R., Miller, J. N., Lu, J., Jeong, E. K., McMahon, W. M., Bigler, E. D., & Lainhart, J. E. (2007). Diffusion tensor imaging of the corpus callosum in Autism. Neuroimage, 34, 61–73. PubMedCrossRef
go back to reference American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed.), Text Revision. Washington, DC. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed.), Text Revision. Washington, DC.
go back to reference Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: evidence from a British twin study. Psychology of Medicine, 25, 63–77. CrossRef Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: evidence from a British twin study. Psychology of Medicine, 25, 63–77. CrossRef
go back to reference Bailey, A., Luthert, P., Dean, A., Harding, B., Janota, I., Montgomery, M., Rutter, M., & Lantos, P. (1998). A clinicopathological study of autism. Brain, 121, 889–905. PubMedCrossRef Bailey, A., Luthert, P., Dean, A., Harding, B., Janota, I., Montgomery, M., Rutter, M., & Lantos, P. (1998). A clinicopathological study of autism. Brain, 121, 889–905. PubMedCrossRef
go back to reference Barnea-Goraly, N., Kwon, H., Menon, V., Eliez, S., Lotspeich, L., & Reiss, A. L. (2004). White matter structure in autism: Preliminary evidence from diffusion tensor imaging. Biological Psychiatry, 55, 323–326. PubMedCrossRef Barnea-Goraly, N., Kwon, H., Menon, V., Eliez, S., Lotspeich, L., & Reiss, A. L. (2004). White matter structure in autism: Preliminary evidence from diffusion tensor imaging. Biological Psychiatry, 55, 323–326. PubMedCrossRef
go back to reference Boger-Megiddo, I., Shaw, D. W., Friedman, S. D., Sparks, B. F., Artru, A. A., Giedd, J. N., Dawson, G., & Dager, S. R. (2006). Corpus callosum morphometrics in young children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 36, 733–739. PubMedCrossRef Boger-Megiddo, I., Shaw, D. W., Friedman, S. D., Sparks, B. F., Artru, A. A., Giedd, J. N., Dawson, G., & Dager, S. R. (2006). Corpus callosum morphometrics in young children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 36, 733–739. PubMedCrossRef
go back to reference Borenstein, M., Rothstein, H., & Cohen, J. (2000). Power and Precision, version 2.0. www.PowerAndPrecision.com. Borenstein, M., Rothstein, H., & Cohen, J. (2000). Power and Precision, version 2.0. www.PowerAndPrecision.com.
go back to reference Chakrabarti, S., & Fombonne, E. (2001). Pervasive developmental disorders in preschool children. Journal of the American Medical Association, 285, 3093–3099. PubMedCrossRef Chakrabarti, S., & Fombonne, E. (2001). Pervasive developmental disorders in preschool children. Journal of the American Medical Association, 285, 3093–3099. PubMedCrossRef
go back to reference Chung, M. K., Dalton, K. M., Alexander, A. L., & Davidson, R. J. (2004). Less white matter concentration in autism: 2D voxel-based morphometry. Neuroimage, 23, 242–251. PubMedCrossRef Chung, M. K., Dalton, K. M., Alexander, A. L., & Davidson, R. J. (2004). Less white matter concentration in autism: 2D voxel-based morphometry. Neuroimage, 23, 242–251. PubMedCrossRef
go back to reference Coleman, M., & Gillberg, C. (1985). The biology of the autistic syndromes. New York: Praeger Publishers. Coleman, M., & Gillberg, C. (1985). The biology of the autistic syndromes. New York: Praeger Publishers.
go back to reference Connolly, A. M., Chez, M., Streif, E. M., Keeling, R. M., Golumbek, P. T., Kwon, J. M., Riviello, J. J., Robinson, R. G., Neuman, R. J., & Deuel, R. M. K. (2006). Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau–Kleffner syndrome, and epilepsy. Biological Psychiatry, 59, 354–363. PubMedCrossRef Connolly, A. M., Chez, M., Streif, E. M., Keeling, R. M., Golumbek, P. T., Kwon, J. M., Riviello, J. J., Robinson, R. G., Neuman, R. J., & Deuel, R. M. K. (2006). Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau–Kleffner syndrome, and epilepsy. Biological Psychiatry, 59, 354–363. PubMedCrossRef
go back to reference Connolly, A. M., Chez, M. G., Pestronk, A., Arnold, S. T., Mehta, S., & Deuel, R. K. (1999). Serum autoantibodies to brain in Landau–Kleffner variant, autism, and other neurologic disorders. Journal of Pediatrics, 134, 607–613. PubMedCrossRef Connolly, A. M., Chez, M. G., Pestronk, A., Arnold, S. T., Mehta, S., & Deuel, R. K. (1999). Serum autoantibodies to brain in Landau–Kleffner variant, autism, and other neurologic disorders. Journal of Pediatrics, 134, 607–613. PubMedCrossRef
go back to reference Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., Lincoln, A. J., Pizzo, S., Schreibman, L., Haas, R. H., Akshoomoff, N. A., & Courchesne, R. Y. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study. Neurology, 57, 245–254. PubMed Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., Lincoln, A. J., Pizzo, S., Schreibman, L., Haas, R. H., Akshoomoff, N. A., & Courchesne, R. Y. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study. Neurology, 57, 245–254. PubMed
go back to reference Deibler, G. E., Martenson, R. E., & Kies, M. W. (1972). Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Preparative Biochemistry, 2, 139–165. PubMedCrossRef Deibler, G. E., Martenson, R. E., & Kies, M. W. (1972). Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Preparative Biochemistry, 2, 139–165. PubMedCrossRef
go back to reference Detskey, P. Z., Bigbee, J. W., & DeVries, G. H. (1988). Isolation and characterization of axolemma-enriched fractions from discrete areas of bovine CNS. Neurochemical Research, 13, 449–454. PubMedCrossRef Detskey, P. Z., Bigbee, J. W., & DeVries, G. H. (1988). Isolation and characterization of axolemma-enriched fractions from discrete areas of bovine CNS. Neurochemical Research, 13, 449–454. PubMedCrossRef
go back to reference Egaas, B., Courchesne, E., & Saitoh, O. (1995). Reduced size of corpus callosum in autism. Archives of Neurology, 52, 794–801. PubMed Egaas, B., Courchesne, E., & Saitoh, O. (1995). Reduced size of corpus callosum in autism. Archives of Neurology, 52, 794–801. PubMed
go back to reference Filipek, P. A. (1996). Brief report: neuroimaging in autism: The state of the science 1995. Journal of Autism and Developmental Disorders, 26, 211–215. PubMedCrossRef Filipek, P. A. (1996). Brief report: neuroimaging in autism: The state of the science 1995. Journal of Autism and Developmental Disorders, 26, 211–215. PubMedCrossRef
go back to reference Fombonne, E. (2003). The prevalence of autism. Journal of the American Medical Association, 289, 87–89. PubMedCrossRef Fombonne, E. (2003). The prevalence of autism. Journal of the American Medical Association, 289, 87–89. PubMedCrossRef
go back to reference Fujinami, R. S., Zurbriggen, A., & Powell, H. C. (1988). Monoclonal antibody defines determinant between Theiler’s virus and lipid-like structures. Journal of Neuroimmunology, 20, 25–32. PubMedCrossRef Fujinami, R. S., Zurbriggen, A., & Powell, H. C. (1988). Monoclonal antibody defines determinant between Theiler’s virus and lipid-like structures. Journal of Neuroimmunology, 20, 25–32. PubMedCrossRef
go back to reference Gillberg, C., & Wing, L. (1999). Autism: Not an extremely rare disorder. Acta Psychiatra Scandinavica, 99, 399–406. CrossRef Gillberg, C., & Wing, L. (1999). Autism: Not an extremely rare disorder. Acta Psychiatra Scandinavica, 99, 399–406. CrossRef
go back to reference Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., Flodman, P., & Spence, M. A. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33, 607–616. PubMedCrossRef Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, C., Flodman, P., & Spence, M. A. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33, 607–616. PubMedCrossRef
go back to reference Hardan, A. Y., Minshew, N. J., & Keshavan, M. S. (2000). Corpus callosum size in autism. Neurology, 55, 1033–1036. PubMed Hardan, A. Y., Minshew, N. J., & Keshavan, M. S. (2000). Corpus callosum size in autism. Neurology, 55, 1033–1036. PubMed
go back to reference Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S., Jr. (2004). Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology, 55, 530–540. PubMedCrossRef Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S., Jr. (2004). Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology, 55, 530–540. PubMedCrossRef
go back to reference Husted, C. (2006). Structural insight into the role of myelin basic protein in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 103, 4339–4340. PubMedCrossRef Husted, C. (2006). Structural insight into the role of myelin basic protein in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 103, 4339–4340. PubMedCrossRef
go back to reference Just, M. A., Cherkassky, V. L., Keller, T. A., & Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity. Brain, 127, 1811–1821. PubMedCrossRef Just, M. A., Cherkassky, V. L., Keller, T. A., & Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity. Brain, 127, 1811–1821. PubMedCrossRef
go back to reference Kirkman, N. K., Libbey, J. E., Sweeten, T. L., Coon, H. H., Miller, J. N., Stevenson, E. K., Lainhart, J. E., McMahon, W. M., & Fujinami, R. S. (in press). How relevant are GFAP autoantibodies in autism? Journal of Autism and Developmental Disorders. Kirkman, N. K., Libbey, J. E., Sweeten, T. L., Coon, H. H., Miller, J. N., Stevenson, E. K., Lainhart, J. E., McMahon, W. M., & Fujinami, R. S. (in press). How relevant are GFAP autoantibodies in autism? Journal of Autism and Developmental Disorders.
go back to reference Kiessling, L. S., Marcotte, A. C., & Culpepper, L. (1993). Antineuronal antibodies in movement disorders. Pediatrics, 92, 39–43. PubMed Kiessling, L. S., Marcotte, A. C., & Culpepper, L. (1993). Antineuronal antibodies in movement disorders. Pediatrics, 92, 39–43. PubMed
go back to reference Lainhart, J. E., Bigler, E. D., Bocian, M., Coon, H., Dinh, E., Dawson, G., Deutsch, C. K., Dunn, M., Estes, A., Tager-Flusberg, H., Folstein, S., Hepburn, S., Hyman, S., McMahon, W., Minshew, N., Munson, J., Osann, K., Ozonoff, S., Rodier, P., Rogers, S., Sigman, M., Spence, M. A., Stodgell, C. J., & Volkmar, F. (2006). Head circumference and height in autism: A study by the collaborative program of excellence in autism. American Journal of Medical Genetics Part A, 140, 2257–2274. PubMedCrossRef Lainhart, J. E., Bigler, E. D., Bocian, M., Coon, H., Dinh, E., Dawson, G., Deutsch, C. K., Dunn, M., Estes, A., Tager-Flusberg, H., Folstein, S., Hepburn, S., Hyman, S., McMahon, W., Minshew, N., Munson, J., Osann, K., Ozonoff, S., Rodier, P., Rogers, S., Sigman, M., Spence, M. A., Stodgell, C. J., & Volkmar, F. (2006). Head circumference and height in autism: A study by the collaborative program of excellence in autism. American Journal of Medical Genetics Part A, 140, 2257–2274. PubMedCrossRef
go back to reference Luyster, R., Richler, J., Risi, S., Hsu, W.-L., Dawson, G., Bernier, R., Dunn, M., Hepburn, S., Hyman, S. L., McMahon, W. M., Goudie-Nice, J., Minshew, N., Rogers, S., Sigman, M., Spence, M. A., Goldberg, W. A., Tager-Flusberg, H., Volkmar, F. R., & Lord, C. (2005). Early regression in social communication in autism spectrum disorders: A CPEA Study. Developmental Neuropsychology, 27, 311–336. PubMedCrossRef Luyster, R., Richler, J., Risi, S., Hsu, W.-L., Dawson, G., Bernier, R., Dunn, M., Hepburn, S., Hyman, S. L., McMahon, W. M., Goudie-Nice, J., Minshew, N., Rogers, S., Sigman, M., Spence, M. A., Goldberg, W. A., Tager-Flusberg, H., Volkmar, F. R., & Lord, C. (2005). Early regression in social communication in autism spectrum disorders: A CPEA Study. Developmental Neuropsychology, 27, 311–336. PubMedCrossRef
go back to reference Manes, F., Piven, J., Vrancic, D., Nanclares, V., Plebst, C., & Starkstein, S. E. (1999). An MRI study of the corpus callosum and cerebellum in mentally retarded autistic individuals. Journal of Neuropsychiatry and Clinical Neurosciences, 11, 470–474. PubMed Manes, F., Piven, J., Vrancic, D., Nanclares, V., Plebst, C., & Starkstein, S. E. (1999). An MRI study of the corpus callosum and cerebellum in mentally retarded autistic individuals. Journal of Neuropsychiatry and Clinical Neurosciences, 11, 470–474. PubMed
go back to reference Minshew, N. J., Goldstein, G., & Siegel, D. J. (1997). Neuropsychologic functioning in autism: profile of a complex information processing disorder. Journal of the International Neuropsychological Society, 3, 303–316. PubMed Minshew, N. J., Goldstein, G., & Siegel, D. J. (1997). Neuropsychologic functioning in autism: profile of a complex information processing disorder. Journal of the International Neuropsychological Society, 3, 303–316. PubMed
go back to reference Musse, A. A., Boggs, J. M., & Harauz, G. (2006). Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope. Proceedings of the National Academy of Sciences of the United States of America, 103, 4422–4427. PubMedCrossRef Musse, A. A., Boggs, J. M., & Harauz, G. (2006). Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope. Proceedings of the National Academy of Sciences of the United States of America, 103, 4422–4427. PubMedCrossRef
go back to reference Nelson, K. B. (1991). Prenatal and perinatal factors in the etiology of autism. Pediatrics, 87, 761–766. PubMed Nelson, K. B. (1991). Prenatal and perinatal factors in the etiology of autism. Pediatrics, 87, 761–766. PubMed
go back to reference Piven, J., Bailey, J., Ranson, B. J., & Arndt, S. (1997). An MRI study of the corpus callosum in autism. American Journal of Psychiatry, 154, 1051–1056. PubMed Piven, J., Bailey, J., Ranson, B. J., & Arndt, S. (1997). An MRI study of the corpus callosum in autism. American Journal of Psychiatry, 154, 1051–1056. PubMed
go back to reference Plioplys, A. V., Greaves, A., Kazemi, K., & Silverman, E. (1994). Immunoglobin reactivity in autism and Rett’s syndrome. Developmental Brain Dysfunction, 7, 12–16. Plioplys, A. V., Greaves, A., Kazemi, K., & Silverman, E. (1994). Immunoglobin reactivity in autism and Rett’s syndrome. Developmental Brain Dysfunction, 7, 12–16.
go back to reference Sambrook, J., Fritsch, E. F., & Maniatis, T. (1989). Molecular cloning: A laboratory manual. New York: Cold Spring Harbor Laboratory. Sambrook, J., Fritsch, E. F., & Maniatis, T. (1989). Molecular cloning: A laboratory manual. New York: Cold Spring Harbor Laboratory.
go back to reference Schotte, A., Janssen, P. F., Megens, A. A., & Leysen, J. E. (1993). Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain Research, 631, 191–202. PubMedCrossRef Schotte, A., Janssen, P. F., Megens, A. A., & Leysen, J. E. (1993). Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain Research, 631, 191–202. PubMedCrossRef
go back to reference Singer, H. S., Giuliano, J. D., Hansen, B. H., Hallett, J. J., Laurino, J. P., Benson, M., & Kiessling, L. S. (1998). Antibodies against human putamen in children with Tourette’s syndrome. Neurology, 50, 1618–1624. PubMed Singer, H. S., Giuliano, J. D., Hansen, B. H., Hallett, J. J., Laurino, J. P., Benson, M., & Kiessling, L. S. (1998). Antibodies against human putamen in children with Tourette’s syndrome. Neurology, 50, 1618–1624. PubMed
go back to reference Singer, H. S., Morris, C. M., Williams, P. N., Yoon, D. Y., Hong, J. J., & Zimmerman, A. W. (2006). Antibrain antibodies in children with autism and their unaffected siblings. Journal of Neuroimmunology, 178, 149–155. PubMedCrossRef Singer, H. S., Morris, C. M., Williams, P. N., Yoon, D. Y., Hong, J. J., & Zimmerman, A. W. (2006). Antibrain antibodies in children with autism and their unaffected siblings. Journal of Neuroimmunology, 178, 149–155. PubMedCrossRef
go back to reference Singh, V. K., Lin, S. X., Newell, E., & Nelson, C. (2002). Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. Journal of Biomedical Science, 9, 359–364. PubMedCrossRef Singh, V. K., Lin, S. X., Newell, E., & Nelson, C. (2002). Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. Journal of Biomedical Science, 9, 359–364. PubMedCrossRef
go back to reference Singh, V. K., Lin, S. X., & Yang, V. C. (1998). Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clinical Immunology and Immunopathology, 89, 105–108. PubMedCrossRef Singh, V. K., Lin, S. X., & Yang, V. C. (1998). Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clinical Immunology and Immunopathology, 89, 105–108. PubMedCrossRef
go back to reference Singh, V. K., & Rivas, W. H. (2004). Prevalence of serum antibodies to caudate nucleus in autistic children. Neuroscience Letters, 355, 53–56. PubMedCrossRef Singh, V. K., & Rivas, W. H. (2004). Prevalence of serum antibodies to caudate nucleus in autistic children. Neuroscience Letters, 355, 53–56. PubMedCrossRef
go back to reference Singh, V. K., Warren, R., Averett, R., & Ghaziuddin, M. (1997). Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatric Neurology, 17, 88–90. PubMedCrossRef Singh, V. K., Warren, R., Averett, R., & Ghaziuddin, M. (1997). Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatric Neurology, 17, 88–90. PubMedCrossRef
go back to reference Singh, V. K., Warren, R. P., Odell, J. D., Warren, W. L., & Cole, P. (1993). Antibodies to myelin basic protein in children with autistic behavior. Brain Behavior and Immunity, 7, 97–103. CrossRef Singh, V. K., Warren, R. P., Odell, J. D., Warren, W. L., & Cole, P. (1993). Antibodies to myelin basic protein in children with autistic behavior. Brain Behavior and Immunity, 7, 97–103. CrossRef
go back to reference Swedo, S. E., Leonard, H. L., Garvey, M., Mittleman, B., Allen, A. J., Perlmutter, S., Lougee, L., Dow, S., Zamkoff, J., & Dubbert, B. K. (1998). Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. American Journal of Psychiatry, 155, 264–271. PubMed Swedo, S. E., Leonard, H. L., Garvey, M., Mittleman, B., Allen, A. J., Perlmutter, S., Lougee, L., Dow, S., Zamkoff, J., & Dubbert, B. K. (1998). Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. American Journal of Psychiatry, 155, 264–271. PubMed
go back to reference Tolley, N. D., Tsunoda, I., & Fujinami, R. S. (1999). DNA vaccination against Theiler’s murine encephalomyelitis virus leads to alterations in demyelinating disease. Journal of Virology, 73, 993–1000. PubMed Tolley, N. D., Tsunoda, I., & Fujinami, R. S. (1999). DNA vaccination against Theiler’s murine encephalomyelitis virus leads to alterations in demyelinating disease. Journal of Virology, 73, 993–1000. PubMed
go back to reference Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67–81. PubMedCrossRef Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67–81. PubMedCrossRef
go back to reference Vidal, C. N., Nicolson, R., DeVito, T. J., Hayashi, K. M., Geaga, J. A., Drost, D. J., Williamson, P. C., Rajakumar, N., Sui, Y., Dutton, R. A., Toga, A. W., & Thompson, P. M. (2006). Mapping corpus callosum deficits in autism: an index of aberrant cortical connectivity. Biological Psychiatry, 60, 218–225. PubMedCrossRef Vidal, C. N., Nicolson, R., DeVito, T. J., Hayashi, K. M., Geaga, J. A., Drost, D. J., Williamson, P. C., Rajakumar, N., Sui, Y., Dutton, R. A., Toga, A. W., & Thompson, P. M. (2006). Mapping corpus callosum deficits in autism: an index of aberrant cortical connectivity. Biological Psychiatry, 60, 218–225. PubMedCrossRef
go back to reference Vojdani, A., Campbell, A. W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. (2002). Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. Journal of Neuroimmunology, 129, 168–177. PubMedCrossRef Vojdani, A., Campbell, A. W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. (2002). Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. Journal of Neuroimmunology, 129, 168–177. PubMedCrossRef
go back to reference Waiter, G. D., Williams, J. H., Murray, A. D., Gilchrist, A., Perrett, D. I., & Whiten, A. (2005). Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: A voxel-based investigation. Neuroimage, 24, 455–461. PubMedCrossRef Waiter, G. D., Williams, J. H., Murray, A. D., Gilchrist, A., Perrett, D. I., & Whiten, A. (2005). Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: A voxel-based investigation. Neuroimage, 24, 455–461. PubMedCrossRef
go back to reference Yamada, M., Zurbriggen, A., Oldstone, M. B. A., & Fujinami, R. S. (1991). Common immunologic determinant between human immunodeficiency virus type 1 gp41 and astrocytes. Journal of Virology, 65, 1370–1376. PubMed Yamada, M., Zurbriggen, A., Oldstone, M. B. A., & Fujinami, R. S. (1991). Common immunologic determinant between human immunodeficiency virus type 1 gp41 and astrocytes. Journal of Virology, 65, 1370–1376. PubMed
go back to reference Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. Journal of the American Medical Association, 289, 49–55. PubMedCrossRef Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. Journal of the American Medical Association, 289, 49–55. PubMedCrossRef
go back to reference Yeh, C.-B., Wu, C.-H., Tsung, H.-C., Chen, C.-W., Shyu, J.-F., & Leckman, J. F. (2006). Antineural antibody in patients with Tourette’s syndrome and their family members. Journal of Biomedical Science, 13, 101–112. PubMedCrossRef Yeh, C.-B., Wu, C.-H., Tsung, H.-C., Chen, C.-W., Shyu, J.-F., & Leckman, J. F. (2006). Antineural antibody in patients with Tourette’s syndrome and their family members. Journal of Biomedical Science, 13, 101–112. PubMedCrossRef
go back to reference Zimmerman, A. W., Connors, S. L., Matteson, K. J., Lee, L. C., Singer, H. S., Castaneda, J. A., & Pearce, D. A. (2007). Maternal antibrain antibodies in autism. Brain Behavior and Immunity, 21, 351–357. CrossRef Zimmerman, A. W., Connors, S. L., Matteson, K. J., Lee, L. C., Singer, H. S., Castaneda, J. A., & Pearce, D. A. (2007). Maternal antibrain antibodies in autism. Brain Behavior and Immunity, 21, 351–357. CrossRef
go back to reference Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005). Cerebrospinal fluid and serum markers of inflammation in autism. Pediatric Neurology, 33, 195–201. PubMedCrossRef Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005). Cerebrospinal fluid and serum markers of inflammation in autism. Pediatric Neurology, 33, 195–201. PubMedCrossRef
Metagegevens
Titel
Are There Enhanced MBP Autoantibodies in Autism?
Auteurs
Jane E. Libbey
Hilary H. Coon
Nikki J. Kirkman
Thayne L. Sweeten
Judith N. Miller
Edward K. Stevenson
Janet E. Lainhart
William M. McMahon
Robert S. Fujinami
Publicatiedatum
01-02-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0400-6

Andere artikelen Uitgave 2/2008

Journal of Autism and Developmental Disorders 2/2008 Naar de uitgave