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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2008

01-02-2008 | Original Paper

How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome?

Auteurs: Nikki J. Kirkman, Jane E. Libbey, Thayne L. Sweeten, Hilary H. Coon, Judith N. Miller, Edward K. Stevenson, Janet E. Lainhart, William M. McMahon, Robert S. Fujinami

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2008

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Abstract

Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.
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Metagegevens
Titel
How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome?
Auteurs
Nikki J. Kirkman
Jane E. Libbey
Thayne L. Sweeten
Hilary H. Coon
Judith N. Miller
Edward K. Stevenson
Janet E. Lainhart
William M. McMahon
Robert S. Fujinami
Publicatiedatum
01-02-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0398-9