Brief CommunicationAntibodies to Myelin Basic Protein in Children with Autistic Behavior
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Plasma levels of nerve growth factor in Egyptian autistic children: Relation to hyperserotonemia and autoimmunity
2021, Journal of NeuroimmunologyCitation Excerpt :Increased serum levels of anti-MBP were found in 77.2% of autistic children. Previous studies also reported increased serum levels of anti-MBP in autistic children (Singh et al., 1993; Skalny et al., 2018). Despite of the fact that the origins of autoimmunity and the production of brain auto-antibodies in autism are unknown, the major histocompatibility complex genes and their products (e.g., HLA-DRB1 and C4B null alleles) might be involved (Mostafa et al., 2013).
Mercury as a hapten: A review of the role of toxicant-induced brain autoantibodies in autism and possible treatment considerations
2020, Journal of Trace Elements in Medicine and BiologyAutoantibody and autism spectrum disorder: A systematic review
2020, Research in Autism Spectrum DisordersT cell populations in children with autism spectrum disorder and co-morbid gastrointestinal symptoms
2020, Brain, Behavior, and Immunity - HealthA potential mechanistic role for neuroinflammation in reward processing impairments in autism spectrum disorder
2019, Biological PsychologyCitation Excerpt :Anti-brain antibodies are not only present in some mothers of children with ASD but are also present in children and adults with ASD (Hoffmann et al., 2016). These anti-brain autoantibodies target a variety of neural components (Connolly et al., 1999; Singh, Warren, Odell, Warren, & Cole, 1993; Singh, Singh, & Warren, 1997) and are significantly more prominent in individuals with ASD (Goines et al., 2011; Wills et al., 2009). In addition, these antibodies appear to be most significantly elevated in ASD within brain regions associated with reward processing, including the dorsal striatum, prefrontal cortex (PFC) and anterior cingulate gyrus (ACG), as well as the cerebellum (Singer et al., 2006).
IGF – Autism prevention/amelioration
2019, Medical Hypotheses