Circulating autoantibodies to neuronal and glial filament proteins in autism
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Cited by (197)
Mercury as a hapten: A review of the role of toxicant-induced brain autoantibodies in autism and possible treatment considerations
2020, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :Numerous studies reveal autoantibodies in autism, and specifically, brain autoantibodies, as listed in Table 1 [2,5,27–47]. Brain autoantibodies found in autism include autoantibodies to: (1) human neuronal progenitor cells (a biological cell that has a tendency to differentiate into a specific type of cell); (2) MBP; (3) neuron-axon filament protein (NAFP, which provides structural support for axons); (4) brain endothelial cells (a key component of the blood brain barrier); (5) serotonin receptors; (6) GFAP; (7) brain derived neurotrophic factor (BDNF, a member of the neurotrophin family of growth factors); (8) neuronal tissue; (9) myelin associated glycoprotein; and (10) various brain proteins in the cerebellum, hypothalamus, prefrontal cortex, cingulate gyrus, caudate putamen, cerebral cortex and caudate nucleus [2,5,27–47]. Importantly, brain autoantibodies in autism are found to correlate with the severity of the disorder [39,46].
Serum levels of Glial fibrillary acidic protein in Chinese children with autism spectrum disorders
2017, International Journal of Developmental NeuroscienceMaternal antineuronal antibodies and risk of childhood autism spectrum disorders: A case–control study
2016, Journal of the Chinese Medical AssociationImmune Dysfunction in Autism Spectrum Disorder
2016, Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual DisabilityNo evidence of antibodies against GAD65 and other specific antigens in children with autism
2015, BBA ClinicalCitation Excerpt :Thus, the relevance, if any, of autoantibodies in ASD based on these methodologies remains unclear. Additionally, specific antigen immunoassays have been used to measure autoantibodies in ASD including autoantibodies against target proteins such as glial fibrillary acidic protein (GFAP), myelin basic protein (MBP) and glutamic acid decarboxylase-65 (GAD65) [11–15]. Singh et al. reported that subjects with ASD had a higher prevalence of autoantibodies against GFAP compared to controls [14], yet another group found no association of autoantibodies against GFAP with ASD [11].
Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders
2015, Brain, Behavior, and Immunity
This work was supported in part by private donations to Dr. Singh at the University of Michigan. He thanks undergraduate students Padma Guthikonda, Kathleen Ang, and Tiffany Heutel for laboratory assistance. The authors thank all blood donors for their participation in this project.