Skip to main content
Top
Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2019

03-01-2019 | Original Paper

A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children

Auteurs: Hajar Mazahery, Cathryn A. Conlon, Kathryn L. Beck, Owen Mugridge, Marlena C. Kruger, Welma Stonehouse, Carlos A. Camargo Jr., Barbara J. Meyer, Bobby Tsang, Beatrix Jones, Pamela R. von Hurst

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2019

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D3, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Al-Haidar, F. A. (2008). Parental attitudes toward the prescription of psychotropic medications for their children. Journal of Family & Community Medicine, 15(1), 35–42. Al-Haidar, F. A. (2008). Parental attitudes toward the prescription of psychotropic medications for their children. Journal of Family & Community Medicine, 15(1), 35–42.
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, D.C.: American Psychiatric AssociationCrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, D.C.: American Psychiatric AssociationCrossRef
go back to reference Brown, T., Morrison, I. C., & Stagnitti, K. (2010). The reliability of two sensory processing scales used with school-age children: Comparing the response consistency of mothers, fathers, and classroom teachers rating the same child. Journal of Occupational Therapy, Schools, & Early Intervention, 3(4), 331–347. https://doi.org/10.1080/19411243.2010.541775.CrossRef Brown, T., Morrison, I. C., & Stagnitti, K. (2010). The reliability of two sensory processing scales used with school-age children: Comparing the response consistency of mothers, fathers, and classroom teachers rating the same child. Journal of Occupational Therapy, Schools, & Early Intervention, 3(4), 331–347. https://​doi.​org/​10.​1080/​19411243.​2010.​541775.CrossRef
go back to reference Cheng, Y. S., Tseng, P. T., Chen, Y. W., Stubbs, B., Yang, W.-C., Chen, T. Y., & Lin, P. Y. (2017). Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: A meta-analysis of randomized controlled trials. Neuropsychiatric Disease and Treatment, 13, 2531–2543. https://doi.org/10.2147/NDT.S147305.CrossRefPubMedPubMedCentral Cheng, Y. S., Tseng, P. T., Chen, Y. W., Stubbs, B., Yang, W.-C., Chen, T. Y., & Lin, P. Y. (2017). Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: A meta-analysis of randomized controlled trials. Neuropsychiatric Disease and Treatment, 13, 2531–2543. https://​doi.​org/​10.​2147/​NDT.​S147305.CrossRefPubMedPubMedCentral
go back to reference Constantino, J., & Gruber, C. (2012). The social responsiveness scale, Second Edition (SRS-2). Los Angeles: Western Psychological Services. Constantino, J., & Gruber, C. (2012). The social responsiveness scale, Second Edition (SRS-2). Los Angeles: Western Psychological Services.
go back to reference Flock, M. R., Skulas-Ray, A. C., Harris, W. S., Etherton, T. D., Fleming, J. A., & Kris-Etherton, P. M. (2013). Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: A dose-response randomized controlled trial. Journal of American Heart Association, 2(6), e000513. https://doi.org/10.1161/jaha.113.000513.CrossRef Flock, M. R., Skulas-Ray, A. C., Harris, W. S., Etherton, T. D., Fleming, J. A., & Kris-Etherton, P. M. (2013). Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: A dose-response randomized controlled trial. Journal of American Heart Association, 2(6), e000513. https://​doi.​org/​10.​1161/​jaha.​113.​000513.CrossRef
go back to reference Fox, N., Hunn, A., & Mather, N. (1998). Sampling. Trent Focus for Research and Development in Primary Health Care. Fox, N., Hunn, A., & Mather, N. (1998). Sampling. Trent Focus for Research and Development in Primary Health Care.
go back to reference Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., & Weaver, C. M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 96(7), 1911–1930. https://doi.org/10.1210/jc.2011-0385.CrossRef Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., & Weaver, C. M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 96(7), 1911–1930. https://​doi.​org/​10.​1210/​jc.​2011-0385.CrossRef
go back to reference Institute of Medicine. (2011). Dietary reference intakes for calcium and vitamin D. Washington, DC, USA: The National Academies Press. Institute of Medicine. (2011). Dietary reference intakes for calcium and vitamin D. Washington, DC, USA: The National Academies Press.
go back to reference Katan, M. B., Deslypere, J. P., van Birgelen, A. P., Penders, M., & Zegwaard, M. (1997). Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study. Journal of Lipid Research, 38(10), 2012–2022.PubMed Katan, M. B., Deslypere, J. P., van Birgelen, A. P., Penders, M., & Zegwaard, M. (1997). Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study. Journal of Lipid Research, 38(10), 2012–2022.PubMed
go back to reference Lewis, R. D., Laing, E. M., Hill Gallant, K. M., Hall, D. B., McCabe, G. P., Hausman, D. B., & Weaver, C. M. (2013). A randomized trial of vitamin D3 supplementation in children: Dose-response effects on vitamin D metabolites and calcium absorption. The Journal of Clinical Endocrinology & Metabolism, 98(12), 4816–4825. https://doi.org/10.1210/jc.2013-2728.CrossRef Lewis, R. D., Laing, E. M., Hill Gallant, K. M., Hall, D. B., McCabe, G. P., Hausman, D. B., & Weaver, C. M. (2013). A randomized trial of vitamin D3 supplementation in children: Dose-response effects on vitamin D metabolites and calcium absorption. The Journal of Clinical Endocrinology & Metabolism, 98(12), 4816–4825. https://​doi.​org/​10.​1210/​jc.​2013-2728.CrossRef
go back to reference Marí-Bauset, S., Llopis-González, A., Zazpe-García, I., Marí-Sanchis, A., & Morales-Suárez-Varela, M. (2015). Nutritional status of children with autism spectrum disorders (ASDs): A case–control study. Journal of Autism and Developmental Disordorder, 45(1), 203–212. https://doi.org/10.1007/s10803-014-2205-8.CrossRef Marí-Bauset, S., Llopis-González, A., Zazpe-García, I., Marí-Sanchis, A., & Morales-Suárez-Varela, M. (2015). Nutritional status of children with autism spectrum disorders (ASDs): A case–control study. Journal of Autism and Developmental Disordorder, 45(1), 203–212. https://​doi.​org/​10.​1007/​s10803-014-2205-8.CrossRef
go back to reference Mazahery, H., Stonehouse, W., Delshad, M., Kruger, M. C., Conlon, C. A., Beck, K. L., & von Hurst, P. R. (2017). Relationship between long chain n–3 polyunsaturated fatty acids and autism spectrum disorder: Systematic review and meta-analysis of case–control and randomised controlled trials. Nutrients, 9(2), 28. https://doi.org/10.3390/nu9020155.CrossRef Mazahery, H., Stonehouse, W., Delshad, M., Kruger, M. C., Conlon, C. A., Beck, K. L., & von Hurst, P. R. (2017). Relationship between long chain n–3 polyunsaturated fatty acids and autism spectrum disorder: Systematic review and meta-analysis of case–control and randomised controlled trials. Nutrients, 9(2), 28. https://​doi.​org/​10.​3390/​nu9020155.CrossRef
go back to reference Ministry of Health and Cancer Society of New Zealand. (2012). Consensus Statement on Vitamin D and Sun Exposure in New Zealand. Wellington: Ministry of Health and Cancer Society of New Zealand. Ministry of Health and Cancer Society of New Zealand. (2012). Consensus Statement on Vitamin D and Sun Exposure in New Zealand. Wellington: Ministry of Health and Cancer Society of New Zealand.
go back to reference Parham, L. D., Ecker, C., Miller-Kuhaneck, H., Henry, D. A., & Glennon, T. (2007). Sensory processing measure (SPM) manual. Los Angeles: Western Psychological Services. Parham, L. D., Ecker, C., Miller-Kuhaneck, H., Henry, D. A., & Glennon, T. (2007). Sensory processing measure (SPM) manual. Los Angeles: Western Psychological Services.
go back to reference Patrick, L., & Salik, R. (2005). The effect of essential fatty acid supplementation on language development and learning skills in autism and Asperger’s syndrome. Autism Asperger’s Digestion, 39, 36–37. Patrick, L., & Salik, R. (2005). The effect of essential fatty acid supplementation on language development and learning skills in autism and Asperger’s syndrome. Autism Asperger’s Digestion, 39, 36–37.
go back to reference Raine, A., Portnoy, J., Liu, J., Mahoomed, T., & Hibbeln, J. R. (2015). Reduction in behavior problems with omega-3 supplementation in children aged 8–16 years: A randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 56(5), 509–520. https://doi.org/10.1111/jcpp.12314.CrossRefPubMed Raine, A., Portnoy, J., Liu, J., Mahoomed, T., & Hibbeln, J. R. (2015). Reduction in behavior problems with omega-3 supplementation in children aged 8–16 years: A randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 56(5), 509–520. https://​doi.​org/​10.​1111/​jcpp.​12314.CrossRefPubMed
go back to reference Rockell, J. E. P., Skeaff, C. M., Venn, B. J., Williams, S. M., & Green, T. J. (2008). Vitamin D insufficiency in New Zealanders during the winter is associated with higher parathyroid hormone concentrations: Implications for bone health? New Zealand Medical Journal, 121(1286), 75–84.PubMed Rockell, J. E. P., Skeaff, C. M., Venn, B. J., Williams, S. M., & Green, T. J. (2008). Vitamin D insufficiency in New Zealanders during the winter is associated with higher parathyroid hormone concentrations: Implications for bone health? New Zealand Medical Journal, 121(1286), 75–84.PubMed
go back to reference Rothman, K. J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1(1), 43–46.CrossRef Rothman, K. J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1(1), 43–46.CrossRef
go back to reference Saad, K., Abdel-Rahman, A. A., Elserogy, Y. M., Al-Atram, A. A., El-Houfey, A. A., Othman, H. A., & Abdel-Salam, A. M. (2018). Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 59(1), 20–29. https://doi.org/10.1111/jcpp.12652.CrossRefPubMed Saad, K., Abdel-Rahman, A. A., Elserogy, Y. M., Al-Atram, A. A., El-Houfey, A. A., Othman, H. A., & Abdel-Salam, A. M. (2018). Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 59(1), 20–29. https://​doi.​org/​10.​1111/​jcpp.​12652.CrossRefPubMed
go back to reference Ucuz, I. I., Dursun, O. B., Esin, İS., Özgeriş, F. B., Kurt, N., Kiziltunç, A., & Orbak, Z. (2015). The relationship between Vitamin D, autistic spectrum disorders, and cognitive development: Do glial cell line-derived neurotrophic factor and nerve growth factor play a role in this relationship? International Journal of Developmental Disabilities, 61(4), 222–230. https://doi.org/10.1179/2047387714Y.0000000054.CrossRef Ucuz, I. I., Dursun, O. B., Esin, İS., Özgeriş, F. B., Kurt, N., Kiziltunç, A., & Orbak, Z. (2015). The relationship between Vitamin D, autistic spectrum disorders, and cognitive development: Do glial cell line-derived neurotrophic factor and nerve growth factor play a role in this relationship? International Journal of Developmental Disabilities, 61(4), 222–230. https://​doi.​org/​10.​1179/​2047387714Y.​0000000054.CrossRef
go back to reference Yui, K., Koshiba, M., Nakamura, S., & Kobayashi, Y. (2012). Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: A double-blind, placebo-controlled, randomized trial. Journal of Clinincal Psychopharmacology, 32(2), 200–206. https://doi.org/10.1097/JCP.0b013e3182485791.CrossRef Yui, K., Koshiba, M., Nakamura, S., & Kobayashi, Y. (2012). Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: A double-blind, placebo-controlled, randomized trial. Journal of Clinincal Psychopharmacology, 32(2), 200–206. https://​doi.​org/​10.​1097/​JCP.​0b013e3182485791​.CrossRef
Metagegevens
Titel
A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children
Auteurs
Hajar Mazahery
Cathryn A. Conlon
Kathryn L. Beck
Owen Mugridge
Marlena C. Kruger
Welma Stonehouse
Carlos A. Camargo Jr.
Barbara J. Meyer
Bobby Tsang
Beatrix Jones
Pamela R. von Hurst
Publicatiedatum
03-01-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3860-y

Andere artikelen Uitgave 5/2019

Journal of Autism and Developmental Disorders 5/2019 Naar de uitgave