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03-01-2019 | Original Paper | Uitgave 5/2019

A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 5/2019

Auteurs:: Hajar Mazahery, Cathryn A. Conlon, Kathryn L. Beck, Owen Mugridge, Marlena C. Kruger, Welma Stonehouse, Carlos A. Camargo Jr., Barbara J. Meyer, Bobby Tsang, Beatrix Jones, Pamela R. von Hurst

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Abstract

We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D₃, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made.

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Titel: A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children
Auteurs:: Hajar Mazahery
Cathryn A. Conlon
Kathryn L. Beck
Owen Mugridge
Marlena C. Kruger
Welma Stonehouse
Carlos A. Camargo Jr.
Barbara J. Meyer
Bobby Tsang
Beatrix Jones
Pamela R. von Hurst
Publicatiedatum: 03-01-2019
DOI: https://doi.org/10.1007/s10803-018-3860-y
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 5/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children

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Design and Development for Individuals with ASD: Fostering Multidisciplinary Approaches Through Personas

Gender Differences in Pragmatic Communication in School-Aged Children with Autism Spectrum Disorder (ASD)

Intuitive Moral Reasoning in High-Functioning Autism Spectrum Disorder: A Matter of Social Schemas?

Course and Predictors of Sleep and Co-occurring Problems in Children with Autism Spectrum Disorder