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Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2016

14-12-2015 | Original Paper

Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum

Auteurs: E. C. Azmitia, Z. T. Saccomano, M. F. Alzoobaee, M. Boldrini, P. M. Whitaker-Azmitia

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2016

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Abstract

In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections of autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling in cells of the vascular system, indicating blood vessels plasticity. Evidence of angiogenesis was seen throughout superior temporal cortex (primary auditory cortex), fusiform cortex (face recognition center), pons/midbrain and cerebellum in postmortem brains from ASD patients but not control brains. We found significant increases in both nestin and CD34, which are markers of angiogenesis localized to pericyte cells and endothelial cells, respectively. This labeling profile is indicative of splitting (intussusceptive), rather than sprouting, angiogenesis indicating the blood vessels are in constant flux rather than continually expanding.
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Metagegevens
Titel
Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum
Auteurs
E. C. Azmitia
Z. T. Saccomano
M. F. Alzoobaee
M. Boldrini
P. M. Whitaker-Azmitia
Publicatiedatum
14-12-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2672-6