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11-01-2016 | Original Paper

Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome

Auteurs: Emeline Crutcher, May Ali, John Harrison, Judit Sovago, Baltazar Gomez-Mancilla, Christian P. Schaaf

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2016

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Abstract

15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford–Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.
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Metagegevens
Titel
Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome
Auteurs
Emeline Crutcher
May Ali
John Harrison
Judit Sovago
Baltazar Gomez-Mancilla
Christian P. Schaaf
Publicatiedatum
11-01-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2694-0