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04-11-2019 | Original Paper

Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference

Auteurs: Anita A. Panjwani, Yuelong Ji, Jed W. Fahey, Amanda Palmer, Guoying Wang, Xiumei Hong, Barry Zuckerman, Xiaobin Wang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2020

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Abstract

In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24–72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings.
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Literatuur
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Metagegevens
Titel
Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference
Auteurs
Anita A. Panjwani
Yuelong Ji
Jed W. Fahey
Amanda Palmer
Guoying Wang
Xiumei Hong
Barry Zuckerman
Xiaobin Wang
Publicatiedatum
04-11-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-04264-x

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