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Journal of Autism and Developmental Disorders

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04-11-2019 | Original Paper

Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference

Auteurs: Anita A. Panjwani, Yuelong Ji, Jed W. Fahey, Amanda Palmer, Guoying Wang, Xiumei Hong, Barry Zuckerman, Xiaobin Wang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2020

Abstract

In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24–72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings.

vorige artikel Development of Episodic Memory and Foresight in High-Functioning Preschoolers with ASD

volgende artikel The Effects of Stability Ball Seating on the Behavior of Children with Autism During Instructional Activities

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Titel: Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference
Auteurs: Anita A. Panjwani
Yuelong Ji
Jed W. Fahey
Amanda Palmer
Guoying Wang
Xiumei Hong
Barry Zuckerman
Xiaobin Wang
Publicatiedatum: 04-11-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04264-x

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