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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2012

01-08-2012 | Original Paper

Exploring the Relationship Between Autism Spectrum Disorder and Epilepsy Using Latent Class Cluster Analysis

Auteurs: Michael L. Cuccaro, Roberto F. Tuchman, Kara L. Hamilton, Harry H. Wright, Ruth K. Abramson, Jonathan L. Haines, John R. Gilbert, Margaret Pericak-Vance

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2012

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Abstract

Epilepsy co-occurs frequently in autism spectrum disorders (ASD). Understanding this co-occurrence requires a better understanding of the ASD-epilepsy phenotype (or phenotypes). To address this, we conducted latent class cluster analysis (LCCA) on an ASD dataset (N = 577) which included 64 individuals with epilepsy. We identified a 5-cluster solution with one cluster showing a high rate of epilepsy (29%), earlier age at first recognition, and high rates of repetitive object use and unusual sensory interests. We also conducted LCCA on an ASD-epilepsy subset from the overall dataset (N = 64) which yielded three clusters, the largest of which had impairments in language and motor development; the remaining clusters, while not as developmentally impaired were characterized by different levels of repetitive and sensory behaviors.
Literatuur
go back to reference Aman, M. G., & Singh, N. B. (1994). Aberrant behavior checklist–community, supplementary manual. East Aurora, NY: Slosson Educational Publications. Aman, M. G., & Singh, N. B. (1994). Aberrant behavior checklist–community, supplementary manual. East Aurora, NY: Slosson Educational Publications.
go back to reference Amiet, C., Gourfinkel-An, I., Bouzamon, A., Tordjman, S., Baulac, M., Lechat, P., et al. (2010). Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis. Biological Psychiatry, 7, 577–582. Amiet, C., Gourfinkel-An, I., Bouzamon, A., Tordjman, S., Baulac, M., Lechat, P., et al. (2010). Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis. Biological Psychiatry, 7, 577–582.
go back to reference Anderson, G. M. (2008). The potential role for emergence in autism. Autism Research: Official Journal of the International Society for Autism Research, 1(1), 18–30. Anderson, G. M. (2008). The potential role for emergence in autism. Autism Research: Official Journal of the International Society for Autism Research, 1(1), 18–30.
go back to reference Baird, G., Charman, T., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2008). Regression, developmental trajectory and associated problems in disorders in the autism spectrum: The SNAP study. Journal of Autism and Developmental Disorders, 38(10), 1827–1836. Baird, G., Charman, T., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2008). Regression, developmental trajectory and associated problems in disorders in the autism spectrum: The SNAP study. Journal of Autism and Developmental Disorders, 38(10), 1827–1836.
go back to reference Brinkley, J., Nations, L., Abramson, R. K., Hall, A., Wright, H. H., Gabriels, R., et al. (2007). Factor analysis of the aberrant behavior checklist in individuals with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 1049–1059. CrossRef Brinkley, J., Nations, L., Abramson, R. K., Hall, A., Wright, H. H., Gabriels, R., et al. (2007). Factor analysis of the aberrant behavior checklist in individuals with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 1049–1059. CrossRef
go back to reference Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, electroencephalographic abnormalities, and regression in children with autism. Journal of Virology, 20, 27–31. Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, electroencephalographic abnormalities, and regression in children with autism. Journal of Virology, 20, 27–31.
go back to reference Cuccaro, M. L., Shao, Y., Bass, M. P., Abramson, R. K., Ravan, S. A., Wright, H. H., et al. (2003). Behavioral comparisons in autistic individuals from multiplex and singleton families. Journal of Autism and Developmental Disorders, 33, 87–91. PubMedCrossRef Cuccaro, M. L., Shao, Y., Bass, M. P., Abramson, R. K., Ravan, S. A., Wright, H. H., et al. (2003). Behavioral comparisons in autistic individuals from multiplex and singleton families. Journal of Autism and Developmental Disorders, 33, 87–91. PubMedCrossRef
go back to reference Eaves, L. C., Ho, H. H., & Eaves, D. M. (1994). Subtypes of autism by cluster analysis. Journal of Autism and Developmental Disorders, 24, 3–22. PubMedCrossRef Eaves, L. C., Ho, H. H., & Eaves, D. M. (1994). Subtypes of autism by cluster analysis. Journal of Autism and Developmental Disorders, 24, 3–22. PubMedCrossRef
go back to reference Ganesalingam, J., Stahl, D., Wijesekera, L., Galtrey, C., Shaw, C. E., Leigh, P. N., et al. (2009). Latent cluster analysis of ALS phenotypes identifies prognostically differing groups. PloS One, 4(9), e7107. PubMedCrossRef Ganesalingam, J., Stahl, D., Wijesekera, L., Galtrey, C., Shaw, C. E., Leigh, P. N., et al. (2009). Latent cluster analysis of ALS phenotypes identifies prognostically differing groups. PloS One, 4(9), e7107. PubMedCrossRef
go back to reference Giannotti, F., Cortesi, F., Cerquiglini, A., Miraglia, D., Vagnoni, C., Sebastiani, T., et al. (2008). An investigation of sleep characteristics, EEG abnormalities and epilepsy in developmentally regressed and non-regressed children with autism. Journal of Autism and Developmental Disorders, 38(10), 1888–1897. Giannotti, F., Cortesi, F., Cerquiglini, A., Miraglia, D., Vagnoni, C., Sebastiani, T., et al. (2008). An investigation of sleep characteristics, EEG abnormalities and epilepsy in developmentally regressed and non-regressed children with autism. Journal of Autism and Developmental Disorders, 38(10), 1888–1897.
go back to reference Giovanardi, R. P., Posar, A., & Parmeggiani, A. (2000). Epilepsy in adolescents and young adults with autistic disorder. Brain & Development, 22, 102–106. Giovanardi, R. P., Posar, A., & Parmeggiani, A. (2000). Epilepsy in adolescents and young adults with autistic disorder. Brain & Development, 22, 102–106.
go back to reference Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., Deprey, L. J., et al. (2008). Regression in autism: Prevalence and associated factors in the CHARGE study. Ambulatory Pediatrics: The Official Journal of the Ambulatory Pediatric Association, 8(1), 25–31. Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., Deprey, L. J., et al. (2008). Regression in autism: Prevalence and associated factors in the CHARGE study. Ambulatory Pediatrics: The Official Journal of the Ambulatory Pediatric Association, 8(1), 25–31.
go back to reference Hara, H. (2007). Autism and epilepsy: A retrospective follow-up study. Brain & Development, 29(8), 486–490. Hara, H. (2007). Autism and epilepsy: A retrospective follow-up study. Brain & Development, 29(8), 486–490.
go back to reference Hrdlicka, M., Dudova, I., Beranova, I., Lisy, J., Belsan, T., Neuwirth, J., et al. (2005). Subtypes of autism by cluster analysis based on structural MRI data. European Child and Adolescent Psychiatry, 14(3), 138–144. PubMedCrossRef Hrdlicka, M., Dudova, I., Beranova, I., Lisy, J., Belsan, T., Neuwirth, J., et al. (2005). Subtypes of autism by cluster analysis based on structural MRI data. European Child and Adolescent Psychiatry, 14(3), 138–144. PubMedCrossRef
go back to reference Hu, V. W., & Steinberg, M. E. (2009). Novel clustering of items from the autism diagnostic interview-revised to define phenotypes within autism spectrum disorders. Autism Research : Official Journal of the International Society for Autism Research, 2(2), 67–77. Hu, V. W., & Steinberg, M. E. (2009). Novel clustering of items from the autism diagnostic interview-revised to define phenotypes within autism spectrum disorders. Autism Research : Official Journal of the International Society for Autism Research, 2(2), 67–77.
go back to reference Kilincaslan, A., & Mukaddes, N. M. (2009). Pervasive developmental disorders in individuals with cerebral palsy. Developmental Medicine and Child Neurology, 51(4), 289–294. Kilincaslan, A., & Mukaddes, N. M. (2009). Pervasive developmental disorders in individuals with cerebral palsy. Developmental Medicine and Child Neurology, 51(4), 289–294.
go back to reference Ma, D., Salyakina, D., Jaworski, J. M., Konidari, I., Whitehead, P. L., Andersen, A. N., et al. (2009). A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. Annals of Human Genetics, 73(Pt 3), 263–273. PubMedCrossRef Ma, D., Salyakina, D., Jaworski, J. M., Konidari, I., Whitehead, P. L., Andersen, A. N., et al. (2009). A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. Annals of Human Genetics, 73(Pt 3), 263–273. PubMedCrossRef
go back to reference Meghani, S. H., Lee, C. S., Hanlon, A. L., & Bruner, D. W. (2009). Latent class cluster analysis to understand heterogeneity in prostate cancer treatment utilities. BMC Medical Informatics and Decision Making, 9, 47. Meghani, S. H., Lee, C. S., Hanlon, A. L., & Bruner, D. W. (2009). Latent class cluster analysis to understand heterogeneity in prostate cancer treatment utilities. BMC Medical Informatics and Decision Making, 9, 47.
go back to reference Ming, X., Brimacombe, M., & Wagner, G. C. (2007). Prevalence of motor impairment in autism spectrum disorders. Brain & Development, 29(9), 565–570. Ming, X., Brimacombe, M., & Wagner, G. C. (2007). Prevalence of motor impairment in autism spectrum disorders. Brain & Development, 29(9), 565–570.
go back to reference Moss, H. B., Chen, C. M., & Yi, H. Y. (2007). Subtypes of alcohol dependence in a nationally representative sample. Drug and Alcohol Dependence, 91(2–3), 149–158. PubMedCrossRef Moss, H. B., Chen, C. M., & Yi, H. Y. (2007). Subtypes of alcohol dependence in a nationally representative sample. Drug and Alcohol Dependence, 91(2–3), 149–158. PubMedCrossRef
go back to reference Muthen, L. K., & Muthen, B. O. (2008). Mplus user’s guide (5th ed.). Los Angeles, CA: Muthen & Muthen. Muthen, L. K., & Muthen, B. O. (2008). Mplus user’s guide (5th ed.). Los Angeles, CA: Muthen & Muthen.
go back to reference Parmeggiani, A., Barcia, G., Posar, A., Raimondi, E., Santucci, M., & Scaduto, M. C. (2010). Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders. Brain & Development, 32(9), 783–789. Parmeggiani, A., Barcia, G., Posar, A., Raimondi, E., Santucci, M., & Scaduto, M. C. (2010). Epilepsy and EEG paroxysmal abnormalities in autism spectrum disorders. Brain & Development, 32(9), 783–789.
go back to reference Rutter, M., LeCouteur, A., & Lord, C. (2003). Autism diagnostic interview, revised (ADI-R). Los Angeles, CA: Western Psychological Services. Rutter, M., LeCouteur, A., & Lord, C. (2003). Autism diagnostic interview, revised (ADI-R). Los Angeles, CA: Western Psychological Services.
go back to reference Sevin, J. A., Matson, J. L., Coe, D., Love, S. R., Matese, M. J., & Benavidez, D. A. (1995). Empirically derived subtypes of pervasive developmental disorders: A cluster analytic study. Journal of Autism and Developmental Disorders, 25, 561–578. PubMedCrossRef Sevin, J. A., Matson, J. L., Coe, D., Love, S. R., Matese, M. J., & Benavidez, D. A. (1995). Empirically derived subtypes of pervasive developmental disorders: A cluster analytic study. Journal of Autism and Developmental Disorders, 25, 561–578. PubMedCrossRef
go back to reference Shinnar, S., Rapin, I., Arnold, S., Tuchman, R. F., Shulman, L., Ballaban-Gil, K., et al. (2001). Language regression in childhood. Pediatric Neurology, 24(3), 183–189. Shinnar, S., Rapin, I., Arnold, S., Tuchman, R. F., Shulman, L., Ballaban-Gil, K., et al. (2001). Language regression in childhood. Pediatric Neurology, 24(3), 183–189.
go back to reference Sparrow, S. S., Cicchetti, D. V., & Balla, D. (2005). Vineland adaptive behavior scales (2nd ed.). Circle Pines, MN: AGS. Sparrow, S. S., Cicchetti, D. V., & Balla, D. (2005). Vineland adaptive behavior scales (2nd ed.). Circle Pines, MN: AGS.
go back to reference Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65, 599–606. PubMedCrossRef Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65, 599–606. PubMedCrossRef
go back to reference Stevens, M. C., Fein, D. A., Dunn, M., Allen, D., Waterhouse, L. H., Feinstein, C., et al. (2000). Subgroups of children with autism by cluster analysis: A longitudinal examination. Journal of the American Academy of Child and Adolescent Psychiatry, 39(3), 346–352. PubMedCrossRef Stevens, M. C., Fein, D. A., Dunn, M., Allen, D., Waterhouse, L. H., Feinstein, C., et al. (2000). Subgroups of children with autism by cluster analysis: A longitudinal examination. Journal of the American Academy of Child and Adolescent Psychiatry, 39(3), 346–352. PubMedCrossRef
go back to reference Tuchman, R. (2006). Autism and epilepsy: What has regression got to do with it? Epilepsy Currents/American Epilepsy Society, 6(4), 107–111. Tuchman, R. (2006). Autism and epilepsy: What has regression got to do with it? Epilepsy Currents/American Epilepsy Society, 6(4), 107–111.
go back to reference Tuchman, R., Cuccaro, M., & Alessandri, M. (2010). Autism and epilepsy: Historical perspective. Brain and Development, 32, 709–718. PubMedCrossRef Tuchman, R., Cuccaro, M., & Alessandri, M. (2010). Autism and epilepsy: Historical perspective. Brain and Development, 32, 709–718. PubMedCrossRef
go back to reference Tuchman, R., Moshe, S. L., & Rapin, I. (2009). Convulsing toward the pathophysiology of autism. Brain and Development, 31, 95–103. PubMedCrossRef Tuchman, R., Moshe, S. L., & Rapin, I. (2009). Convulsing toward the pathophysiology of autism. Brain and Development, 31, 95–103. PubMedCrossRef
go back to reference Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99(4), 560–566. Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99(4), 560–566.
go back to reference Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. The Lancet Neurology, 1, 352–358. CrossRef Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. The Lancet Neurology, 1, 352–358. CrossRef
go back to reference Turk, J., Bax, M., Williams, C., Amin, P., Eriksson, M., & Gillberg, C. (2009). Autism spectrum disorder in children with and without epilepsy: Impact on social functioning and communication. Acta Paediatrica (Oslo, Norway: 1992), 98(4), 675–681. Turk, J., Bax, M., Williams, C., Amin, P., Eriksson, M., & Gillberg, C. (2009). Autism spectrum disorder in children with and without epilepsy: Impact on social functioning and communication. Acta Paediatrica (Oslo, Norway: 1992), 98(4), 675–681.
go back to reference Vermunt, J. K., & Magidson, J. (2002). Latent class cluster analysis. In J. A. Hagenaars & A. L. McCutcheon (Eds.), Applied latent class analysis (pp. 89–106). Cambridge, UK: University of Cambridge Press. CrossRef Vermunt, J. K., & Magidson, J. (2002). Latent class cluster analysis. In J. A. Hagenaars & A. L. McCutcheon (Eds.), Applied latent class analysis (pp. 89–106). Cambridge, UK: University of Cambridge Press. CrossRef
go back to reference Wardlaw, A. J., Silverman, M., Siva, R., Pavord, I. D., & Green, R. (2005). Multi-dimensional phenotyping: Towards a new taxonomy for airway disease. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(10), 1254–1262. CrossRef Wardlaw, A. J., Silverman, M., Siva, R., Pavord, I. D., & Green, R. (2005). Multi-dimensional phenotyping: Towards a new taxonomy for airway disease. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(10), 1254–1262. CrossRef
go back to reference Weatherall, M., Travers, J., Shirtcliffe, P. M., Marsh, S. E., Williams, M. V., Nowitz, M. R., et al. (2009). Distinct clinical phenotypes of airways disease defined by cluster analysis. The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology, 34(4), 812–818. CrossRef Weatherall, M., Travers, J., Shirtcliffe, P. M., Marsh, S. E., Williams, M. V., Nowitz, M. R., et al. (2009). Distinct clinical phenotypes of airways disease defined by cluster analysis. The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology, 34(4), 812–818. CrossRef
Metagegevens
Titel
Exploring the Relationship Between Autism Spectrum Disorder and Epilepsy Using Latent Class Cluster Analysis
Auteurs
Michael L. Cuccaro
Roberto F. Tuchman
Kara L. Hamilton
Harry H. Wright
Ruth K. Abramson
Jonathan L. Haines
John R. Gilbert
Margaret Pericak-Vance
Publicatiedatum
01-08-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1402-y