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04-12-2019 | Original Paper | Uitgave 3/2020 Open Access

Journal of Autism and Developmental Disorders 3/2020

The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes

Tijdschrift:
Journal of Autism and Developmental Disorders > Uitgave 3/2020
Auteurs:
R. Royston, C. Oliver, P. Howlin, A. Dosse, P. Armitage, J. Moss, J. Waite
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10803-019-04317-1) contains supplementary material, which is available to authorized users.

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Abstract

Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.

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