Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in:

16-11-2015 | Original Paper

Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression

Auteurs: Gregory L. Wallace, Lauren Kenworthy, Cara E. Pugliese, Haroon S. Popal, Emily I. White, Emily Brodsky, Alex Martin

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2016

Abstract

Although executive functioning (EF) difficulties are well documented among children and adolescents with autism spectrum disorder (ASD), little is known about real-world measures of EF among adults with ASD. Therefore, this study examined parent-reported real-world EF problems among 35 adults with ASD without intellectual disability and their correlations with adaptive functioning and co-morbid anxiety and depression symptomatology. A variable EF profile was found with prominent deficits occurring in flexibility and metacognition. Flexibility problems were associated with anxiety-related symptoms while metacognition difficulties were associated with depression symptoms and impaired adaptive functioning (though the metacognition-adaptive functioning relationship was moderated by ADHD symptoms). These persistent EF problems are predictors of broader functioning and therefore remain an important treatment target among adults with ASD.

vorige artikel Uh, Um, and Autism: Filler Disfluencies as Pragmatic Markers in Adolescents with Optimal Outcomes from Autism Spectrum Disorder

volgende artikel Trajectories, Long-Term Outcomes and Family Experiences of 76 Adults with Autism Spectrum Disorder

Achenbach, T. M., & Rescorla, L. A. (2003). Manual for the ASEBA adult forms & profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.

Ambery, F. Z., Russell, A. J., Perry, K., Morris, R., & Murphy, D. G. (2006). Neuropsychological functioning in adults with Asperger syndrome. Autism, 10, 551–564. doi: 10.1177/1362361306068507. CrossRefPubMed

Ashwood, K. L., Tye, C., Azadi, B., Cartwright, S., Asherson, P., & Bolton, P. (2015). Brief report: Adaptive functioning in children with ASD, ADHD and ASD + ADHD. Journal of Autism and Developmental Disorders, 45, 2235–2242. doi: 10.1007/s10803-014-2352-y. CrossRefPubMed

Barnard, L., Muldoon, K., Hasan, R., O’Brien, G., & Stewart, M. (2008). Profiling executive dysfunction in adults with autism and comorbid learning disability. Autism, 12, 125–141. doi: 10.1177/1362361307088486. CrossRefPubMed

Blijd-Hoogewys, E. M., Bezemer, M. L., & van Geert, P. L. (2014). Executive functioning in children with ASD: An analysis of the BRIEF. Journal of Autism and Developmental Disorders, 44, 3089–3100. CrossRefPubMed

Cannon, L., Kenworthy, L., Alexander, K. C., Werner, M. A., & Anthony, L. G. (2011). Unstuck and on target! An executive function curriculum to improve flexibility for children with autism spectrum disorders. Baltimore, MD: Paul H. Brookes.

Damasio, A. R., & Maurer, R. G. (1978). A neurological model for childhood autism. Archives of Neurology, 35, 777–786. CrossRefPubMed

Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention (CDC). (2014). Prevalence of autism spectrum disorder among children aged 8 years—Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63, 1–21.

Geurts, H. M., & Vissers, M. E. (2012). Elderly with autism: Executive functions and memory. Journal of Autism and Developmental Disorders, 42, 665–675. doi: 10.1007/s10803-011-1291-0. PubMedCentralCrossRefPubMed

Gilotty, L., Kenworthy, L., Sirian, L., Black, D. O., & Wagner, A. E. (2002). Adaptive skills and executive function in autism spectrum disorders. Child Neuropsychology, 8, 241–248. CrossRefPubMed

Goldstein, G., Minshew, N. J., Allen, D. N., & Seaton, B. E. (2002). High-functioning autism and schizophrenia a comparison of an early and late onset neurodevelopmental disorder. Archives of Clinical Neuropsychology, 17, 461–475. CrossRefPubMed

Gotham, K., Bishop, S. L., Hus, V., Huerta, M., Lund, S., Buja, A., et al. (2013). Exploring the relationship between anxiety and insistence on sameness in autism spectrum disorders. Autism Research, 6, 33–41. doi: 10.1002/aur.1263. PubMedCentralCrossRefPubMed

Granader, Y., Wallace, G. L., Hardy, K. K., Yerys, B. E., Lawson, R. A., Rosenthal, M., et al. (2014). Characterizing the factor structure of parent reported executive function in autism spectrum disorders: The role of cognitive inflexibility. Journal of Autism and Developmental Disorders, 44, 3056–3062. CrossRefPubMed

Harrison, P. L., & Oakland, T. (2003). Adaptive behavior assessment—Second edition manual (ABAS-II). San Antonio, TX: Harcourt Assessment.

Henninger, N. A., & Taylor, J. L. (2013). Outcomes in adults with autism spectrum disorders: A historical perspective. Autism, 17, 103–116. PubMedCentralCrossRefPubMed

Hill, E. L. (2004). Executive dysfunction in autism. Trends in Cognitive Sciences, 8, 26–32. CrossRefPubMed

Hill, E. L., & Bird, C. M. (2006). Executive processes in Asperger syndrome: Patterns of performance in a multiple case series. Neuropsychologia, 44, 2822–2835. doi: 10.1016/j.neuropsychologia.2006.06.007. CrossRefPubMed

Hollocks, M. J., Jones, C. R., Pickles, A., Baird, G., Happé, F., Charman, T., & Simonoff, E. (2014). The association between social cognition and executive functioning and symptoms of anxiety and depression in adolescents with autism spectrum disorders. Autism Research, 7, 216–228. CrossRefPubMed

Howlin, P., & Moss, P. (2012). Adults with autism spectrum disorders. Canadian Journal of Psychiatry, 57, 275–283. PubMed

Johnston, K., Madden, A. K., Bramham, J., & Russell, A. J. (2011). Response inhibition in adults with autism spectrum disorder compared to attention deficit/hyperactivity disorder. Journal of Autism and Developmental Disorders, 41, 903–912. doi: 10.1007/s10803-010-1113-9. CrossRefPubMed

Kenworthy, L., Anthony, L. G., Alexander, K. C., Werner, M. A., Cannon, L., & Greenman, L. (2014a). Solving executive functioning challenges: Simple ways to get kids with autism unstuck and on target. Baltimore, MD: Brookes Publishing Company.

Kenworthy, L., Anthony, L. G., Naiman, D. Q., Cannon, L., Wills, M. C., Werner, M. A., et al. (2014b). Randomized controlled effectiveness trial of executive function intervention for children on the autism spectrum. Journal of Child Psychology and Psychiatry, 55, 374–383. PubMedCentralCrossRefPubMed

Kenworthy, L., Yerys, B. E., Anthony, L. G., & Wallace, G. L. (2008). Understanding executive control in autism spectrum disorders in the lab and in the real world. Neuropsychology Review, 18, 320–338. PubMedCentralCrossRefPubMed

Lai, M. C., Lombardo, M. V., Ruigrok, A. N., Chakrabarti, B., Wheelwright, S. J., Auyeung, B., et al. (2012). Cognition in males and females with autism: Similarities and differences. PLoS One, 7. doi: 10.1371/journal.pone.0047198.

Lainhart, J. E., Bigler, E. D., Bocian, M., Coon, H., Dinh, E., Dawson, G., et al. (2006). Head circumference and height in autism: A study by the Collaborative Program of Excellence in Autism. American Journal of Medical Genetics, 140, 2257–2274. doi: 10.1002/ajmg.a.31465. CrossRefPubMed

Lawson, R. A., Papadakis, A. A., Higginson, C. I., Barnett, J. E., Wills, M. C., Strang, J. F., et al. (2015). Specific executive function impairments predict comorbid psychopathology in autism spectrum and attention-deficit/hyperactivity disorders. Neuropsychology, 29, 445–453. CrossRefPubMed

Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. (1989). Autism diagnostic interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–387. CrossRefPubMed

Lopez, B., Lincoln, A., Ozonoff, S., & Lai, Z. (2005). Examining the relationship between executive functions and restricted, repetitive symptoms of autistic disorder. Journal of Autism and Developmental Disorders, 35, 445–460. doi: 10.1007/s10803-005-5035-x. CrossRefPubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., Dilavore, P. C., et al. (2000). The autism diagnostic observation schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. CrossRefPubMed

Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. CrossRefPubMed

Mazurek, M. O. (2014). Loneliness, friendship, and well-being in adults with autism spectrum disorders. Autism, 18, 223–232. CrossRefPubMed

Nakahachi, T., Iwase, M., Takahashi, H., Honaga, E., Sekiyama, R., Ukai, S., et al. (2006). Discrepancy of performance among working memory-related tasks in autism spectrum disorders was caused by task characteristics, apart from working memory, which could interfere with task execution. Psychiatry and Clinical Neurosciences, 60, 312–318. doi: 10.1111/j.1440-1819.2006.01507.x. CrossRefPubMed

Nydén, A., Niklasson, L., Stahlberg, O., Anckarsater, H., Wentz, E., Rastam, M., & Gillberg, C. (2010). Adults with autism spectrum disorders and ADHD neuropsychological aspects. Research in Developmental Disabilities, 31, 1659–1668. doi: 10.1016/j.ridd.2010.04.010. CrossRefPubMed

Olesen, P. J., Westerberg, H., & Klingberg, T. (2004). Increased prefrontal and parietal activity after training of working memory. Nature Neuroscience, 7, 75–79. CrossRefPubMed

Pugliese, C. E., Anthony, L., Strang, J. F., Dudley, K., Wallace, G. L., & Kenworthy, L. (2015). Increasing adaptive behavior skill deficits from childhood to adolescence in autism spectrum disorder: Role of executive function. Journal of Autism and Developmental Disorders, 45, 1579–1587. CrossRefPubMed

Rosenthal, M., Wallace, G. L., Lawson, R., Wills, M. C., Dixon, E., Yerys, B. E., & Kenworthy, L. (2013). Impairments in realworld executive function increase from childhood to adolescence in autism spectrum disorders. Neuropsychology, 27, 13–18. doi: 10.1037/a0031299. CrossRefPubMed

Roth, R. M., Isquith, P. K., & Gioia, G. A. (2005). Behavior rating inventory of executive function—adult version (BRIEF-A). Lutz, FL: Psychological Assessment Resources.

Roux, A. M., Shattuck, P. T., Cooper, B. P., Anderson, K. A., Wagner, M., & Narendorf, S. C. (2013). Postsecondary employment experiences among young adults with an autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 52, 931–939. PubMedCentralCrossRefPubMed

Rumsey, J. M. (1985). Conceptual problem-solving in highly verbal, nonretarded autistic men. Journal of Autism and Developmental Disorders, 15, 23–36. CrossRefPubMed

Rumsey, J. M., & Hamburger, S. D. (1988). Neuropsychological findings in high-functioning men with infantile autism, residual state. Journal of Clinical and Experimental Neuropsychology, 10, 201–221. doi: 10.1080/01688638808408236. CrossRefPubMed

Rumsey, J. M., & Hamburger, S. D. (1990). Neuropsychological divergence of high-level autism and severe dyslexia. Journal of Autism and Developmental Disorders, 20, 155–168. CrossRefPubMed

Sachse, M., Schlitt, S., Hainz, D., Ciaramidaro, A., Schirman, S., Walter, H., et al. (2013). Executive and visuo-motor function in adolescents and adults with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43, 1222–1235. CrossRefPubMed

Sparrow, S., Balla, D. A., & Cicchetti, D. (1984). Vineland adaptive behavior scales (expanded form). Circle Pine, MN: American Guidance Service.

Sparrow, S. S., Cicchetti, D., & Balla, D. A. (2005). Vineland adaptive behavior scales—2nd edition manual. Minneapolis, MN: NCS Pearson Inc.

Taylor, J. L., & Seltzer, M. M. (2011). Employment and post-secondary educational activities for young adults with autism spectrum disorders during the transition to adulthood. Journal of Autism and Developmental Disorders, 40, 1431–1446. CrossRef

Towgood, K. J., Meuwese, J. D., Gilbert, S. J., Turner, M. S., & Burgess, P. W. (2009). Advantages of the multiple case series approach to the study of cognitive deficits in autism spectrum disorder. Neuropsychologia, 47, 2981–2988. doi: 10.1016/j.neuropsychologia.2009.06.028. PubMedCentralCrossRefPubMed

Vergara-Lopez, C., Lopez-Vergara, H. I., & Colder, C. R. (2013). Executive functioning moderates the relationship between motivation and adolescent depressive symptoms. Personality and Individual Differences, 54, 18–22. PubMedCentralCrossRefPubMed

Williams, D. L., Goldstein, G., Carpenter, P. A., & Minshew, N. J. (2005). Verbal and spatial working memory in autism. Journal of Autism and Developmental Disorders, 35, 747–756. doi: 10.1007/s10803-005-0021-x. CrossRefPubMed

Wilson, C. E., Happé, F., Wheelwright, S. J., Ecker, C., Lombardo, M. V., Johnston, P., et al. (2014). The neuropsychology of male adults with high-functioning autism or Asperger syndrome. Autism Research, 7, 568–581. doi: 10.1002/aur.1394. PubMedCentralCrossRefPubMed

Yerys, B. E., Wallace, G. L., Sokoloff, J., Shook, D. A., James, J. D., & Kenworthy, L. (2009). Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders. Autism Research, 2, 322–333. doi: 10.1002/aur.103. PubMedCentralPubMed

Titel: Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression
Auteurs: Gregory L. Wallace
Lauren Kenworthy
Cara E. Pugliese
Haroon S. Popal
Emily I. White
Emily Brodsky
Alex Martin
Publicatiedatum: 16-11-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2655-7

Bohn Stafleu van Loghum

Tip

Swipe om te navigeren naar een ander artikel

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 3/2016

Trajectories, Long-Term Outcomes and Family Experiences of 76 Adults with Autism Spectrum Disorder

Postural Control Deficits in Autism Spectrum Disorder: The Role of Sensory Integration

Altered Gesture and Speech Production in ASD Detract from In-Person Communicative Quality

Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder

An Analysis of State Autism Educational Assessment Practices and Requirements

Body Constraints on Motor Simulation in Autism Spectrum Disorders