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Gepubliceerd in: Journal of Autism and Developmental Disorders 12/2022

11-01-2022 | Original Paper

Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder

Auteurs: Sarah A. Keim, Abigail Jude, Katie Smith, Aiman Q. Khan, Daniel L. Coury, Joseph Rausch, Shivika Udaipuria, Megan Norris, Lindsay R. Bartram, Anita R. Narayanan, Lynette K. Rogers

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2022

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Abstract

This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6 years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90 days based on participant weight. Erythrocyte FAs and the cytokines, IL-1β, IL-2, IFNγ, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40 mol% for EPA and 1.62 mol% for DHA) and reduced IL-2 levels compared to placebo (− 0.17 pg/mL, 95% CI − 0.31, − 0.02, d = − 0.62). Omega 3–6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3–6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209.
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Metagegevens
Titel
Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder
Auteurs
Sarah A. Keim
Abigail Jude
Katie Smith
Aiman Q. Khan
Daniel L. Coury
Joseph Rausch
Shivika Udaipuria
Megan Norris
Lindsay R. Bartram
Anita R. Narayanan
Lynette K. Rogers
Publicatiedatum
11-01-2022
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-05396-9

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