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Journal of Autism and Developmental Disorders

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11-01-2022 | Original Paper

Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder

Auteurs: Sarah A. Keim, Abigail Jude, Katie Smith, Aiman Q. Khan, Daniel L. Coury, Joseph Rausch, Shivika Udaipuria, Megan Norris, Lindsay R. Bartram, Anita R. Narayanan, Lynette K. Rogers

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2022

Abstract

This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6 years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90 days based on participant weight. Erythrocyte FAs and the cytokines, IL-1β, IL-2, IFNγ, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40 mol% for EPA and 1.62 mol% for DHA) and reduced IL-2 levels compared to placebo (− 0.17 pg/mL, 95% CI − 0.31, − 0.02, d = − 0.62). Omega 3–6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3–6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209.

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Titel: Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder
Auteurs: Sarah A. Keim
Abigail Jude
Katie Smith
Aiman Q. Khan
Daniel L. Coury
Joseph Rausch
Shivika Udaipuria
Megan Norris
Lindsay R. Bartram
Anita R. Narayanan
Lynette K. Rogers
Publicatiedatum: 11-01-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05396-9

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