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Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2012

01-09-2012 | Original Paper

Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica

Auteurs: Mohammad H. Rahbar, Maureen Samms-Vaughan, Katherine A. Loveland, Deborah A. Pearson, Jan Bressler, Zhongxue Chen, Manouchehr Ardjomand-Hessabi, Sydonnie Shakespeare-Pellington, Megan L. Grove, Compton Beecher, Kari Bloom, Eric Boerwinkle

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2012

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Abstract

Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.
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Metagegevens
Titel
Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica
Auteurs
Mohammad H. Rahbar
Maureen Samms-Vaughan
Katherine A. Loveland
Deborah A. Pearson
Jan Bressler
Zhongxue Chen
Manouchehr Ardjomand-Hessabi
Sydonnie Shakespeare-Pellington
Megan L. Grove
Compton Beecher
Kari Bloom
Eric Boerwinkle
Publicatiedatum
01-09-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1438-z