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Journal of Autism and Developmental Disorders

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26-04-2021 | Original Paper

The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder

Auteurs: Marilena M. DeMayo, Izabella Pokorski, Yun J. C. Song, Rinku Thapa, Shrujna Patel, Zahava Ambarchi, Domenic Soligo, Indra Sadeli, Emma E. Thomas, Ian B. Hickie, Adam J. Guastella

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2022

Abstract

There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3–12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial.

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Titel: The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder
Auteurs: Marilena M. DeMayo
Izabella Pokorski
Yun J. C. Song
Rinku Thapa
Shrujna Patel
Zahava Ambarchi
Domenic Soligo
Indra Sadeli
Emma E. Thomas
Ian B. Hickie
Adam J. Guastella
Publicatiedatum: 26-04-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05028-2

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