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Journal of Autism and Developmental Disorders

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26-04-2021 | Original Paper

The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder

Auteurs: Marilena M. DeMayo, Izabella Pokorski, Yun J. C. Song, Rinku Thapa, Shrujna Patel, Zahava Ambarchi, Domenic Soligo, Indra Sadeli, Emma E. Thomas, Ian B. Hickie, Adam J. Guastella

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2022

Abstract

There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3–12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial.

vorige artikel Community-based Parent Education for Caregivers of Children Newly Diagnosed with Autism Spectrum Disorder

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Ajram, L. A., Horder, J., Mendez, M. A., Galanopoulos, A., Brennan, L. P., Wichers, R. H., Robertson, D. M., Murphy, C. M., Zinkstok, J., Ivin, G., Heasman, M., Meek, D., Tricklebank, M. D., Barker, G. J., Lythgoe, D., Edden, R. A. E., Williams, S. C., Murphy, D. G. M., & McAlonan, G. M. (2017). Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder. Translational Psychiatry, 7(5), e1137. https://doi.org/10.1038/tp.2017.104 [Original Article].CrossRefPubMedPubMedCentral

Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., Kasai, K., & Yamasue, H. (2015). Oxytocin’s neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial. Molecular Psychiatry, 20(4), 447–453. https://doi.org/10.1038/mp.2014.74CrossRefPubMed

Beversdorf, D. Q. (2016). Phenotyping, etiological factors, and biomarkers: Toward precision medicine in autism spectrum disorders. Journal of Developmental and Behavioral Pediatrics, 37(8), 659–673. https://doi.org/10.1097/dbp.0000000000000351CrossRefPubMedPubMedCentral

Bharti, B., Malhi, P., & Khandelwal, N. (2016). MRI customized play therapy in children reduces the need for sedation-a randomized controlled trial. Indian Journal of Pediatrics, 83(3), 209–213. https://doi.org/10.1007/s12098-015-1917-xCrossRefPubMed

Biomarkers Definitions Working Group. (2001). Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clinical Pharmacology and Therapeutics, 69(3), 89–95. https://doi.org/10.1067/mcp.2001.113989CrossRef

Chantiluke, K., Barrett, N., Giampietro, V., Santosh, P., Brammer, M., Simmons, A., Murphy, D. G., & Rubia, K. (2015). Inverse fluoxetine effects on inhibitory brain activation in non-comorbid boys with ADHD and with ASD. Psychopharmacology, 232(12), 2071–2082. https://doi.org/10.1007/s00213-014-3837-2CrossRefPubMed

Charman, T., Pickles, A., Simonoff, E., Chandler, S., Loucas, T., & Baird, G. (2011). IQ in children with autism spectrum disorders: Data from the special needs and autism project (SNAP). Psychological Medicine, 41(3), 619–627. https://doi.org/10.1017/S0033291710000991CrossRefPubMed

Cox, A. D., Virues-Ortega, J., Julio, F., & Martin, T. L. (2017). Establishing motion control in children with autism and intellectual disability: Applications for anatomical and functional MRI. Journal of Applied Behavior Analysis, 50(1), 8–26. https://doi.org/10.1002/jaba.351CrossRefPubMed

Daly, E. M., Deeley, Q., Ecker, C., Craig, M., Hallahan, B., Murphy, C., Johnston, P., Spain, D., Gillan, N., Brammer, M., Giampietro, V., Lamar, M., Page, L., Toal, F., Cleare, A., Surguladze, S., & Murphy, D. G. (2012). Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletion. Archives of General Psychiatry, 69(10), 1003–1013. https://doi.org/10.1001/archgenpsychiatry.2012.513CrossRefPubMed

de Bie, H. M., Boersma, M., Wattjes, M. P., Adriaanse, S., Vermeulen, R. J., Oostrom, K. J., Huisman, J., Veltman, D. J., & Delemarre-Van de Waal, H. A. (2010). Preparing children with a mock scanner training protocol results in high quality structural and functional MRI scans. European Journal of Pediatrics, 169(9), 1079–1085. https://doi.org/10.1007/s00431-010-1181-zCrossRefPubMedPubMedCentral

Dean, D. C., Dirks, H., O’Muircheartaigh, J., Walker, L., Jerskey, B. A., Lehman, K., Han, M., Waskiewicz, N., & Deoni, S. C. (2014). Pediatric neuroimaging using magnetic resonance imaging during non-sedated sleep. Pediatric Radiology, 44(1), 64–72. https://doi.org/10.1007/s00247-013-2752-8CrossRefPubMed

Di Martino, A., O’Connor, D., Chen, B., Alaerts, K., Anderson, J. S., Assaf, M., Balsters, J. H., Baxter, L., Beggiato, A., Bernaerts, S., Blanken, L. M., Bookheimer, S. Y., Braden, B. B., Byrge, L., Castellanos, F. X., Dapretto, M., Delorme, R., Fair, D. A., Fishman, I.,…Milham, M. P. (2017). Enhancing studies of the connectome in autism using the autism brain imaging data exchange II. Scientific Data, 4, 170010. https://doi.org/10.1038/sdata.2017.10CrossRefPubMedPubMedCentral

Di Martino, A., Yan, C. G., Li, Q., Denio, E., Castellanos, F. X., Alaerts, K., Anderson, J. S., Assaf, M., Bookheimer, S. Y., Dapretto, M., Deen, B., Delmonte, S., Dinstein, I., Ertl-Wagner, B., Fair, D. A., Gallagher, L., Kennedy, D. P., Keown, C. L., Keysers, C.,…Milham, M. P. (2014). The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism. Molecular Psychiatry, 19(6), 659–667. https://doi.org/10.1038/mp.2013.78CrossRefPubMed

Erickson, L. C., Scott-Van Zeeland, A. A., Hamilton, G., Lincoln, A., & Golomb, B. A. (2012). Brief report: approaches to 31P-MRS in awake, non-sedated children with and without autism spectrum disorder. Journal of Autism and Developmental Disorders, 42(6), 1120–1126. https://doi.org/10.1007/s10803-011-1359-xCrossRefPubMedPubMedCentral

Esteban, O., Birman, D., Schaer, M., Koyejo, O. O., Poldrack, R. A., & Gorgolewski, K. J. (2017). MRIQC: Advancing the automatic prediction of image quality in MRI from unseen sites. PLoS ONE, 12(9), e0184661. https://doi.org/10.1371/journal.pone.0184661CrossRefPubMedPubMedCentral

Gabrielsen, T. P., Anderson, J. S., Stephenson, K. G., Beck, J., King, J. B., Kellems, R., Top, D. N., Jr., Russell, N. C. C., Anderberg, E., Lundwall, R. A., Hansen, B., & South, M. (2018). Functional MRI connectivity of children with autism and low verbal and cognitive performance. Molecular Autism, 9, 67. https://doi.org/10.1186/s13229-018-0248-yCrossRefPubMedPubMedCentral

Gordon, I., Jack, A., Pretzsch, C. M., Vander Wyk, B., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2016). Intranasal oxytocin enhances connectivity in the neural circuitry supporting social motivation and social perception in children with autism. Scientific Reports, 6, 35054. https://doi.org/10.1038/srep35054CrossRefPubMedPubMedCentral

Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013). Oxytocin enhances brain function in children with autism. Proceedings of the National Academy of Sciences of the United States of America, 110(52), 20953–20958. https://doi.org/10.1073/pnas.1312857110CrossRefPubMedPubMedCentral

Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(5), 693–705. https://doi.org/10.1007/s10803-008-0674-3CrossRefPubMed

Guldenmund, P., Vanhaudenhuyse, A., Sanders, R. D., Sleigh, J., Bruno, M. A., Demertzi, A., Bahri, M. A., Jaquet, O., Sanfilippo, J., Baquero, K., Boly, M., Brichant, J. F., Laureys, S., & Bonhomme, V. (2017). Brain functional connectivity differentiates dexmedetomidine from propofol and natural sleep. British Journal of Anaesthesia, 119(4), 674–684. https://doi.org/10.1093/bja/aex257CrossRefPubMed

Hegarty, J. P., Ferguson, B. J., Zamzow, R. M., Rohowetz, L. J., Johnson, J. D., Christ, S. E., & Beversdorf, D. Q. (2016). Beta-adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder. Brain Imaging and Behavior, 11(5), 1278–1289. https://doi.org/10.1007/s11682-016-9604-8CrossRef

Hegarty, J. P., Zamzow, R. M., Ferguson, B. J., Christ, S. E., Porges, E. C., Johnson, J. D., & Beversdorf, D. Q. (2020). Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism. Autism, 24(3), 795–801. https://doi.org/10.1177/1362361319868633CrossRefPubMed

Hong, S. J., Vogelstein, J. T., Gozzi, A., Bernhardt, B. C., Yeo, B. T. T., Milham, M. P., & Di Martino, A. (2020). Toward neurosubtypes in autism. Biological Psychiatry, 88(1), 111–128. https://doi.org/10.1016/j.biopsych.2020.03.022CrossRefPubMed

Hus, V., Gotham, K., & Lord, C. (2014). Standardizing ADOS domain scores: Separating severity of social affect and restricted and repetitive behaviors. Journal of Autism and Developmental Disorders, 44(10), 2400–2412. https://doi.org/10.1007/s10803-012-1719-1CrossRefPubMedPubMedCentral

Jack, A., & Pelphrey, K. A. (2017). Annual research review: Understudied populations within the autism spectrum-current trends and future directions in neuroimaging research. Journal of Child Psychology and Psychiatry and Allied Disciplines, 58(4), 411–435. https://doi.org/10.1111/jcpp.12687CrossRef

Johnson, N. L., & Bree, O. A. (2014). Social script iPad application versus usual care before undergoing medical imaging: Two case studies of children with autism. Journal of Radiology Nursing, 33(3), 121–126. https://doi.org/10.1016/j.jradnu.2014.04.001CrossRef

King, B. H., Dukes, K., Donnelly, C. L., Sikich, L., McCracken, J. T., Scahill, L., Hollander, E., Bregman, J. D., Anagnostou, E., Robinson, F., Sullivan, L., & Hirtz, D. (2013). Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: A multisite randomized clinical trial. JAMA Pediatrics, 167(11), 1045–1052. https://doi.org/10.1001/jamapediatrics.2013.2698CrossRefPubMedPubMedCentral

Kokina, A., & Kern, L. (2010). Social Story interventions for students with autism spectrum disorders: A meta-analysis. Journal of Autism and Developmental Disorders, 40(7), 812–826. https://doi.org/10.1007/s10803-009-0931-0CrossRefPubMed

Loomes, R., Hull, L., & Mandy, W. P. L. (2017). What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 56(6), 466–474CrossRef

Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule second edition (ADOS-2) Manual (Part 1): Modules 1–4. Western Psychological Services.

Loth, E., Murphy, D. G., & Spooren, W. (2016). Defining precision medicine approaches to autism spectrum disorders: Concepts and challenges. Front Psychiatry, 7, 188. https://doi.org/10.3389/fpsyt.2016.00188CrossRefPubMedPubMedCentral

Loth, E., Spooren, W., Ham, L. M., Isaac, M. B., Auriche-Benichou, C., Banaschewski, T., Baron-Cohen, S., Broich, K., Bölte, S., Bourgeron, T., Charman, T., Collier, D., de Andres-Trelles, F., Durston, S., Ecker, C., Elferink, A., Haberkamp, M., Hemmings, R., Johnson, M. H.,…Murphy, D. G. (2016). Identification and validation of biomarkers for autism spectrum disorders. Nature Reviews Drug Discovery, 15(1), 70–73. https://doi.org/10.1038/nrd.2015.7CrossRefPubMed

Masi, A., Lampit, A., DeMayo, M. M., Glozier, N., Hickie, I. B., & Guastella, A. J. (2017). A comprehensive systematic review and meta-analysis of pharmacological and dietary supplement interventions in paediatric autism: Moderators of treatment response and recommendations for future research. Psychological Medicine, 47(7), 1323–1334. https://doi.org/10.1017/S0033291716003457CrossRefPubMed

Masi, A., Lampit, A., Glozier, N., Hickie, I. B., & Guastella, A. J. (2015). Predictors of placebo response in pharmacological and dietary supplement treatment trials in pediatric autism spectrum disorder: A meta-analysis. Translational Psychiatry, 5(9), e640. https://doi.org/10.1038/tp.2015.143CrossRefPubMedPubMedCentral

McPartland, J. C. (2016). Considerations in biomarker development for neurodevelopmental disorders. Current Opinion in Neurology, 29(2), 118–122. https://doi.org/10.1097/WCO.0000000000000300CrossRefPubMedPubMedCentral

Mikkelsen, M., Barker, P. B., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., Cecil, K. M., Chan, K. L., Chen, D. Y., Craven, A. R., Cuypers, K., Dacko, M., Duncan, N. W., Dydak, U., Edmondson, D. A., Ende, G., Ersland, L., Gao, F., Greenhouse, I., Harris, A. D.,…Edden, R. A. E. (2017). Big GABA: Edited MR spectroscopy at 24 research sites. Neuroimage, 159, 32–45. https://doi.org/10.1016/j.neuroimage.2017.07.021CrossRefPubMed

Murdaugh, D. L., Deshpande, H. D., & Kana, R. K. (2016). The impact of reading intervention on brain responses underlying language in children with autism. Autism Research, 9(1), 141–154. https://doi.org/10.1002/aur.1503CrossRefPubMed

Murdaugh, D. L., Maximo, J. O., Cordes, C. E., O’Kelley, S. E., & Kana, R. K. (2017). From word reading to multisentence comprehension: Improvements in brain activity in children with autism after reading intervention. Neuroimage Clinical, 16, 303–312. https://doi.org/10.1016/j.nicl.2017.08.012CrossRefPubMedPubMedCentral

Murdaugh, D. L., Maximo, J. O., & Kana, R. K. (2015). Changes in intrinsic connectivity of the brain’s reading network following intervention in children with autism. Human Brain Mapping, 36(8), 2965–2979. https://doi.org/10.1002/hbm.22821CrossRefPubMedPubMedCentral

Murphy, D., & Spooren, W. (2012). EU-AIMS: A boost to autism research. Nature Reviews Drug Discovery, 11(11), 815–816. https://doi.org/10.1038/nrd3881CrossRefPubMed

Narayanan, A., White, C. A., Saklayen, S., Scaduto, M. J., Carpenter, A. L., Abduljalil, A., Schmalbrock, P., & Beversdorf, D. Q. (2010). Effect of propranolol on functional connectivity in autism spectrum disorder–a pilot study. Brain Imaging and Behavior, 4(2), 189–197. https://doi.org/10.1007/s11682-010-9098-8CrossRefPubMedPubMedCentral

Nordahl, C. W., Mello, M., Shen, A. M., Shen, M. D., Vismara, L. A., Li, D., Harrington, K., Tanase, C., Goodlin-Jones, B., Rogers, S., Abbeduto, L., & Amaral, D. G. (2016). Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation. Journal of Neurodevelopmental Disorders, 8(1), 20. https://doi.org/10.1186/s11689-016-9154-9CrossRefPubMedPubMedCentral

Nordahl, C. W., Simon, T. J., Zierhut, C., Solomon, M., Rogers, S. J., & Amaral, D. G. (2008). Brief report: Methods for acquiring structural MRI data in very young children with autism without the use of sedation. Journal of Autism and Developmental Disorders, 38(8), 1581–1590. https://doi.org/10.1007/s10803-007-0514-xCrossRefPubMed

Oztan, O., Jackson, L. P., Libove, R. A., Sumiyoshi, R. D., Phillips, J. M., Garner, J. P., Hardan, A. Y., & Parker, K. J. (2018). Biomarker discovery for disease status and symptom severity in children with autism. Psychoneuroendocrinology, 89, 39–45. https://doi.org/10.1016/j.psyneuen.2017.12.022CrossRefPubMed

Pretzsch, C. M., Freyberg, J., Voinescu, B., Lythgoe, D., Horder, J., Mendez, M. A., Wichers, R., Ajram, L., Ivin, G., Heasman, M., Edden, R. A. E., Williams, S., Murphy, D. G. M., Daly, E., & McAlonan, G. M. (2019). Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder. Neuropsychopharmacology, 44(8), 1398–1405. https://doi.org/10.1038/s41386-019-0333-8CrossRefPubMedPubMedCentral

Pretzsch, C. M., Voinescu, B., Lythgoe, D., Horder, J., Mendez, M. A., Wichers, R., Ajram, L., Ivin, G., Heasman, M., Edden, R. A. E., Williams, S., Murphy, D. G. M., Daly, E., & McAlonan, G. M. (2019). Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without autism spectrum disorder (ASD): A single dose trial during magnetic resonance spectroscopy. Translational Psychiatry, 9(1), 313. https://doi.org/10.1038/s41398-019-0654-8CrossRefPubMedPubMedCentral

Raschle, N., Zuk, J., Ortiz-Mantilla, S., Sliva, D. D., Franceschi, A., Grant, P. E., Benasich, A. A., & Gaab, N. (2012). Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. Annals of the New York Academy of Sciences, 1252, 43–50. https://doi.org/10.1111/j.1749-6632.2012.06457.xCrossRefPubMedPubMedCentral

Roid, G., Miller, L., Pomplun, M., & Koch, C. (2013). Leiter international performance scale-third edition. Stoelting Company.

Russell, G., Mandy, W., Elliott, D., White, R., Pittwood, T., & Ford, T. (2019). Selection bias on intellectual ability in autism research: a cross-sectional review and meta-analysis. Molecular Autism, 10, 9. https://doi.org/10.1186/s13229-019-0260-xCrossRefPubMedPubMedCentral

Sandler, A. (2005). Placebo effects in developmental disabilities: implications for research and practice. Mental Retardation and Developmental Disabilities Research Reviews, 11(2), 164–170. https://doi.org/10.1002/mrdd.20065CrossRefPubMed

Sices, L., Pawlowski, K., Farfel, L., Phillips, D., Howe, Y., Cochran, D. M., Choueiri, R., Forbes, P. W., Brewster, S. J., Frazier, J. A., Neumeyer, A., & Bridgemohan, C. (2017). Feasibility of conducting autism biomarker research in the clinical setting. Journal of Developmental and Behavioral Pediatrics, 38(7), 483–492. https://doi.org/10.1097/DBP.0000000000000470CrossRefPubMed

Smith, C. J., Bhanot, A., Norman, E., Mullett, J. E., Bilbo, S. D., McDougle, C. J., Zürcher, N. R., & Hooker, J. M. (2019). A protocol for sedation free MRI and PET imaging in adults with autism spectrum disorder. Journal of Autism and Developmental Disorders, 49(7), 3036–3044. https://doi.org/10.1007/s10803-019-04010-3CrossRefPubMed

Stivaros, S., Garg, S., Tziraki, M., Cai, Y., Thomas, O., Mellor, J., Morris, A. A., Jim, C., Szumanska-Ryt, K., Parkes, L. M., Haroon, H. A., Montaldi, D., Webb, N., Keane, J., Castellanos, F. X., Silva, A. J., Huson, S., Williams, S., Gareth Evans, D.,…Green, J. (2018). Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA). Molecular Autism, 9, 12. https://doi.org/10.1186/s13229-018-0190-zCrossRefPubMedPubMedCentral

Thieba, C., Frayne, A., Walton, M., Mah, A., Benischek, A., Dewey, D., & Lebel, C. (2018). Factors associated with successful MRI scanning in unsedated young children. Frontiers in Pediatrics, 6(146), 146. https://doi.org/10.3389/fped.2018.00146CrossRefPubMedPubMedCentral

Tournier, J. D., Calamante, F., & Connelly, A. (2012). MRtrix: Diffusion tractography in crossing fiber regions. International Journal of Imaging Systems and Technology, 22(1), 53–66. https://doi.org/10.1002/ima.22005CrossRef

Venkataraman, A., Yang, D. Y., Dvornek, N., Staib, L. H., Duncan, J. S., Pelphrey, K. A., & Ventola, P. (2016). Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder. Neuroreport, 27(14), 1081–1085. https://doi.org/10.1097/WNR.0000000000000662CrossRefPubMedPubMedCentral

Ventola, P., Yang, D. Y., Friedman, H. E., Oosting, D., Wolf, J., Sukhodolsky, D. G., & Pelphrey, K. A. (2015). Heterogeneity of neural mechanisms of response to pivotal response treatment. Brain Imaging and Behavior, 9(1), 74–88. https://doi.org/10.1007/s11682-014-9331-yCrossRefPubMedPubMedCentral

Voos, A. C., Pelphrey, K. A., Tirrell, J., Bolling, D. Z., Vander Wyk, B., Kaiser, M. D., McPartland, J. C., Volkmar, F. R., & Ventola, P. (2013). Neural mechanisms of improvements in social motivation after pivotal response treatment: Two case studies. Journal of Autism and Developmental Disorders, 43(1), 1–10. https://doi.org/10.1007/s10803-012-1683-9CrossRefPubMedPubMedCentral

Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., Kamio, Y., Kato, N., Miyashita, Y., Kasai, K., & Yamasue, H. (2014). Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: A randomized trial. JAMA Psychiatry, 71(2), 166–175. https://doi.org/10.1001/jamapsychiatry.2013.3181CrossRefPubMed

Yang, Z. Y., Yue, Q., Xing, H. Y., Tan, Q. Y., Sun, H. Q., Gong, Q. Y., Tan, Z. J., & Quan, H. (2015). A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age. British Journal of Radiology, 88(1052), 20140693. https://doi.org/10.1259/bjr.20140693CrossRef

Yatawara, C. J., Einfeld, S. L., Hickie, I. B., Davenport, T. A., & Guastella, A. J. (2016). The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: A randomized clinical crossover trial. Molecular Psychiatry, 21(9), 1225–1231. https://doi.org/10.1038/mp.2015.162CrossRefPubMed

Titel: The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder
Auteurs: Marilena M. DeMayo
Izabella Pokorski
Yun J. C. Song
Rinku Thapa
Shrujna Patel
Zahava Ambarchi
Domenic Soligo
Indra Sadeli
Emma E. Thomas
Ian B. Hickie
Adam J. Guastella
Publicatiedatum: 26-04-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05028-2

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