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05-05-2021 | Original Paper

A Meta-analysis of Gut Microbiota in Children with Autism

Auteurs: Pedro Andreo-Martínez, María Rubio-Aparicio, Julio Sánchez-Meca, Alejandro Veas, Agustín Ernesto Martínez-González

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2022

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Abstract

Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = − 0.999; 95% CI − 1.549, − 0.449) and Bifidobacterium genera (SMD+ = − 0.513; 95% CI − 0.953, − 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
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Metagegevens
Titel
A Meta-analysis of Gut Microbiota in Children with Autism
Auteurs
Pedro Andreo-Martínez
María Rubio-Aparicio
Julio Sánchez-Meca
Alejandro Veas
Agustín Ernesto Martínez-González
Publicatiedatum
05-05-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-05002-y

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