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01-10-2007 | Original Paper

The Broad Autism Phenotype Questionnaire

Auteurs: Robert S. E. Hurley, Molly Losh, Morgan Parlier, J. Steven Reznick, Joseph Piven

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2007

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Abstract

The broad autism phenotype (BAP) is a set of personality and language characteristics that reflect the phenotypic expression of the genetic liability to autism, in non-autistic relatives of autistic individuals. These characteristics are milder but qualitatively similar to the defining features of autism. A new instrument designed to measure the BAP in adults, the Broad Autism Phenotype Questionnaire (BAPQ), was administered to 86 parents of autistic individuals and 64 community control parents. Sensitivity and specificity of the BAPQ for detecting the BAP were high (>70%). Parents of children with autism had significantly higher scores on all three subscales: aloof personality, rigid personality, and pragmatic language. This instrument provides a valid and efficient measure for characterizing the BAP.
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Literatuur
go back to reference American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (DSM-IV) (4th ed). Washington, DC: American Psychiatric Association. American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (DSM-IV) (4th ed). Washington, DC: American Psychiatric Association.
go back to reference Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British Twin Study. Psychological Medicine, 25, 63–77.PubMedCrossRef Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British Twin Study. Psychological Medicine, 25, 63–77.PubMedCrossRef
go back to reference Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The Autism-Spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.PubMedCrossRef Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The Autism-Spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.PubMedCrossRef
go back to reference Bishop, D. V. M., Mayberry, M., Maley, A., Wong, D., Hill, W., & Hallmayer, J. (2004). Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: A study using the Autism-Spectrum quotient. Journal of Child Psychology and Psychiatry, 45, 1431–1436.PubMedCrossRef Bishop, D. V. M., Mayberry, M., Maley, A., Wong, D., Hill, W., & Hallmayer, J. (2004). Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: A study using the Autism-Spectrum quotient. Journal of Child Psychology and Psychiatry, 45, 1431–1436.PubMedCrossRef
go back to reference Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M. (1994). A case–control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.PubMedCrossRef Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M. (1994). A case–control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.PubMedCrossRef
go back to reference Bradford, Y., Haines, J., Hutcheson, H., Gardiner, M., Braun, T., Sheffield, V., Cassavant, T., Huang, W., Wang, K., Vieland, V., Folstein, S., Santangelo, S., & Piven, J. (2001). Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics-Neuropsychiatric Genetics, 105, 539–547.PubMedCrossRef Bradford, Y., Haines, J., Hutcheson, H., Gardiner, M., Braun, T., Sheffield, V., Cassavant, T., Huang, W., Wang, K., Vieland, V., Folstein, S., Santangelo, S., & Piven, J. (2001). Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics-Neuropsychiatric Genetics, 105, 539–547.PubMedCrossRef
go back to reference Constantino, J. N. (2002). The social responsiveness scale. Los Angeles, CA: Western Psychological Services. Constantino, J. N. (2002). The social responsiveness scale. Los Angeles, CA: Western Psychological Services.
go back to reference Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbachi, A., McKenna, K., Singh, D., & Todd, R. D. (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry, 163, 294–296.PubMedCrossRef Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbachi, A., McKenna, K., Singh, D., & Todd, R. D. (2006). Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry, 163, 294–296.PubMedCrossRef
go back to reference Constantino, J. N., & Todd, R. D. (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57, 655–660.PubMedCrossRef Constantino, J. N., & Todd, R. D. (2005). Intergenerational transmission of subthreshold autistic traits in the general population. Biological Psychiatry, 57, 655–660.PubMedCrossRef
go back to reference Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321.PubMedCrossRef Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321.PubMedCrossRef
go back to reference Hyler, S. E., Rieder, R. O., Williams, J. B., Spitzer, R. L., Lyons, M., & Hendler, J. (1989). A comparison of clinical and self-report diagnoses of DSM-III personality disorders in 552 patients. Comprehensive Psychiatry, 30, 170–178.PubMedCrossRef Hyler, S. E., Rieder, R. O., Williams, J. B., Spitzer, R. L., Lyons, M., & Hendler, J. (1989). A comparison of clinical and self-report diagnoses of DSM-III personality disorders in 552 patients. Comprehensive Psychiatry, 30, 170–178.PubMedCrossRef
go back to reference Kanner, L. (1943). Autistic disturbances of affective content. Nervous Child, 2, 217–250. Kanner, L. (1943). Autistic disturbances of affective content. Nervous Child, 2, 217–250.
go back to reference Landa, R., Piven, J., Wzorek, M. M., Gayle, J. O., Chase, G. A., Folstein, S. E. (1992). Social language usage in parents of autistic individuals. Psychological Medicine, 46, 245–254. Landa, R., Piven, J., Wzorek, M. M., Gayle, J. O., Chase, G. A., Folstein, S. E. (1992). Social language usage in parents of autistic individuals. Psychological Medicine, 46, 245–254.
go back to reference Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, P., Holdgrafer, M., & McLennan, J. (1989). Autism Diagnostic Interview: A standard investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–387.PubMedCrossRef Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, P., Holdgrafer, M., & McLennan, J. (1989). Autism Diagnostic Interview: A standard investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–387.PubMedCrossRef
go back to reference Lord, C., Rutter, M., DiLavore, P., & Risi, S. (2006). Autism diagnostic observation schedule. San Antonio, TX: Western Psychological Services. Lord, C., Rutter, M., DiLavore, P., & Risi, S. (2006). Autism diagnostic observation schedule. San Antonio, TX: Western Psychological Services.
go back to reference Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185–212.PubMedCrossRef Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185–212.PubMedCrossRef
go back to reference Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMedCrossRef Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMedCrossRef
go back to reference Losh, M., & Piven, J. (2006). Social cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes. Journal of Child Psychology and Psychiatry. In press. Losh, M., & Piven, J. (2006). Social cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes. Journal of Child Psychology and Psychiatry. In press.
go back to reference Perry, J. C. (1992). Problems and considerations in the valid assessment of personality disorders. American Journal of Psychiatry, 149, 1645–1653.PubMed Perry, J. C. (1992). Problems and considerations in the valid assessment of personality disorders. American Journal of Psychiatry, 149, 1645–1653.PubMed
go back to reference Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry, 154, 185–190.PubMed Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry, 154, 185–190.PubMed
go back to reference Piven, J., Palmer, P., Landa, R., Santangelo, S., Jacobi, D., & Childress, C. (1997). Personality and language characteristics in parents from multiple-incidence autism families. American Journal of Medical Genetics, 74, 398–411.PubMedCrossRef Piven, J., Palmer, P., Landa, R., Santangelo, S., Jacobi, D., & Childress, C. (1997). Personality and language characteristics in parents from multiple-incidence autism families. American Journal of Medical Genetics, 74, 398–411.PubMedCrossRef
go back to reference Piven, J., Wzorek, M., Landa, R., Lainhart, J., Bolton, P., Chase, G. A., & Folstein, S. (1994). P`ersonality characteristics of the parents of autistic individuals. Psychological Medicine, 24, 783–795.PubMed Piven, J., Wzorek, M., Landa, R., Lainhart, J., Bolton, P., Chase, G. A., & Folstein, S. (1994). P`ersonality characteristics of the parents of autistic individuals. Psychological Medicine, 24, 783–795.PubMed
go back to reference Sung, Y. J., Dawson, G., Munson, J., Estes, A., Schellenberg, G. D., & Wijsman, E. M. (2005). Genetic investigation of quantitative traits related to autism: Use of multivariate polygenic models with ascertainment adjustment. American Journal of Human Genetics, 76, 68–81.PubMedCrossRef Sung, Y. J., Dawson, G., Munson, J., Estes, A., Schellenberg, G. D., & Wijsman, E. M. (2005). Genetic investigation of quantitative traits related to autism: Use of multivariate polygenic models with ascertainment adjustment. American Journal of Human Genetics, 76, 68–81.PubMedCrossRef
go back to reference Tyrer, P., & Alexander, J. (1979). Classification of personality disorder. British Journal of Psychiatry, 135, 163–167.PubMedCrossRef Tyrer, P., & Alexander, J. (1979). Classification of personality disorder. British Journal of Psychiatry, 135, 163–167.PubMedCrossRef
Metagegevens
Titel
The Broad Autism Phenotype Questionnaire
Auteurs
Robert S. E. Hurley
Molly Losh
Morgan Parlier
J. Steven Reznick
Joseph Piven
Publicatiedatum
01-10-2007
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0299-3