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16-04-2019 | Original Paper

The Association Between Serum Vitamin D3 Levels and Autism Among Jordanian Boys

Tijdschrift:: Journal of Autism and Developmental Disorders

Auteurs:: Loai Alzghoul, Laith N. AL-Eitan, Mohammad Aladawi, Maher Odeh, Osama Abu Hantash

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Abstract

This study assesses the correlation between vitamin-D deficiency and autism spectrum disorder (ASD) in Jordan. We performed a case–controlled cross-sectional analysis to assess vitamin D levels in 83 children with ASD aged less than 8 years old compared to 106 healthy controls. In addition, the association between vitamin D deficiencies and gastrointestinal (GI) complains and electroencephalogram (EEG) abnormalities commonly found in children with ASD was investigated. Vitamin D levels in ASD patients were significantly lower. Also, Vitamin D levels in ASD patients had significant correlation with GI complains, but no correlation between vitamin D levels and Ca²⁺or EEG abnormalities was detected. These data suggest a possible role for vitamin D deficiency in the pathophysiology of ASD.

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Meer informatie

Abbasnezhad, A., Amani, R., Hajiani, E., Alavinejad, P., Cheraghian, B., & Ghadiri, A. (2016). Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: A randomized double-blind clinical trial. Neurogastroenterology and Motility, 28(10), 1533–1544. https://doi.org/10.1111/nmo.12851.

Aydin, F. N., Aydin, I., & Agilli, M. (2014). Factors affecting the accuracy of vitamin D measurements. Clinical Medicine & Research, 12(1–2), 4. https://doi.org/10.3121/cmr.2014.1231.

Bakken, T. E., Miller, J. A., Ding, S.-L., Sunkin, S. M., Smith, K. A., Ng, L., et al. (2016). A comprehensive transcriptional map of primate brain development. Nature, 535(7612), 367–375. https://doi.org/10.1038/nature18637.

Baxter, A. J., Brugha, T. S., Erskine, H. E., Scheurer, R. W., Vos, T., & Scott, J. G. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45(03), 601–613. https://doi.org/10.1017/S003329171400172X.

Bener, A., Khattab, A. O., & Al-Dabbagh, M. M. (2014). Is high prevalence of Vitamin D deficiency evidence for autism disorder?: In a highly endogamous population. Journal of Pediatric Neurosciences, 9(3), 227–233. https://doi.org/10.4103/1817-1745.147574.

Brandt, A., Godfred, R., Parikh, M., Fortier, N., Haltiner, A., Caylor, L., et al. (2014). Does vitamin D use alter seizure collections during elective adult inpatient video EEG monitering? Neurology, 82(10 Supplement), P6.186.

Bromley, R. (2016). The treatment of epilepsy in pregnancy: The neurodevelopmental risks associated with exposure to antiepileptic drugs. Reproductive Toxicology, 64, 203–210. https://doi.org/10.1016/j.reprotox.2016.06.007.

Cannell, J. J. (2008). Autism and vitamin D. Medical Hypotheses, 70(4), 750–759. https://doi.org/10.1016/J.MEHY.2007.08.016.

Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014). Gastrointestinal problems in children with autism, developmental delays or typical development. Journal of Autism and Developmental Disorders, 44(5), 1117–1127. https://doi.org/10.1007/s10803-013-1973-x.

DeLuca, H. F. (2004). Overview of general physiologic features and functions of vitamin D. The American Journal of Clinical Nutrition, 80(6 Suppl), 1689–1696.

DeVilbiss, E. A., Gardner, R. M., Newschaffer, C. J., & Lee, B. K. (2015). Maternal folate status as a risk factor for autism spectrum disorders: A review of existing evidence. British Journal of Nutrition, 114(05), 663–672. https://doi.org/10.1017/S0007114515002470.

Elsabbagh, M., Divan, G., Koh, Y.-J., Kim, Y. S., Kauchali, S., Marcín, C., et al. (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Research, 5(3), 160–179. https://doi.org/10.1002/aur.239.

Eyles, D., Burne, T., & McGrath, J. (2011). Vitamin D in fetal brain development. Seminars in Cell & Developmental Biology, 22(6), 629–636. https://doi.org/10.1016/J.SEMCDB.2011.05.004.

Eyles, D. W., Feron, F., Cui, X., Kesby, J. P., Harms, L. H., Ko, P., et al. (2009). Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology, 34, S247–S257. https://doi.org/10.1016/J.PSYNEUEN.2009.04.015.

Fernell, E., Bejerot, S., Westerlund, J., Miniscalco, C., Simila, H., Eyles, D., et al. (2015). Autism spectrum disorder and low vitamin D at birth: A sibling control study. Molecular Autism, 6(1), 3. https://doi.org/10.1186/2040-2392-6-3.

Gargus, J. J. (2009). Genetic Calcium Signaling Abnormalities in the Central Nervous System: Seizures, Migraine, and Autism. Annals of the New York Academy of Sciences, 1151(1), 133–156. https://doi.org/10.1111/j.1749-6632.2008.03572.x.

Godar, D. E., & Merrill, S. J. (2017). Untangling the most probable role for vitamin D3 in autism. Dermato-Endocrinology, 9(1), e1387702. https://doi.org/10.1080/19381980.2017.1387702.

Groves, N. J., McGrath, J. J., & Burne, T. H. J. (2014). Vitamin D as a neurosteroid affecting the developing and adult brain. Annual Review of Nutrition, 34(1), 117–141. https://doi.org/10.1146/annurev-nutr-071813-105557.

Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., et al. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095. https://doi.org/10.1001/archgenpsychiatry.2011.76.

Hilger, J., Friedel, A., Herr, R., Rausch, T., Roos, F., Wahl, D. A., et al. (2014). A systematic review of vitamin D status in populations worldwide. British Journal of Nutrition, 111(01), 23–45. https://doi.org/10.1017/S0007114513001840.

Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., et al. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 96(7), 1911–1930. https://doi.org/10.1210/jc.2011-0385.

Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T., Anderson, R. R., et al. (1980). Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science, 210(4466), 203.

Holingue, C., Newill, C., Lee, L.-C., Pasricha, P. J., & Daniele Fallin, M. (2018). Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence. Autism Research, 11(1), 24–36. https://doi.org/10.1002/aur.1854.

Holló, A., Clemens, Z., Kamondi, A., Lakatos, P., & Szűcs, A. (2012). Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study. Epilepsy & Behavior, 24(1), 131–133. https://doi.org/10.1016/j.yebeh.2012.03.011.

Jia, F., Wang, B., Shan, L., Xu, Z., Staal, W. G., & Du, L. (2015). Core symptoms of autism improved after vitamin D supplementation. Pediatrics, 135(1), e196–e198. https://doi.org/10.1542/peds.2014-2121.

Kesby, J. P., Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2011). The effects of vitamin D on brain development and adult brain function. Molecular and Cellular Endocrinology, 347(1–2), 121–127. https://doi.org/10.1016/J.MCE.2011.05.014.

Khuri-Bulos, N., Lang, R. D., Blevins, M., Kudyba, K., Lawrence, L., Davidson, M., et al. (2013). Vitamin D deficiency among newborns in amman, Jordan. Global Journal of Health Science, 6(1), 162–171. https://doi.org/10.5539/gjhs.v6n1p162.

Kočovská, E., Andorsdóttir, G., Weihe, P., Halling, J., Fernell, E., Stóra, T., et al. (2014). Vitamin D in the general population of young adults with autism in the Faroe Islands. Journal of Autism and Developmental Disorders, 44(12), 2996–3005. https://doi.org/10.1007/s10803-014-2155-1.

Lips, P. (2012). Interaction between Vitamin D and calcium. Scandinavian Journal of Clinical and Laboratory Investigation, 72(sup243), 60–64. https://doi.org/10.3109/00365513.2012.681960.

Maeyama, K., Tomioka, K., Nagase, H., Yoshioka, M., Takagi, Y., Kato, T., et al. (2018). Congenital cytomegalovirus infection in children with autism spectrum disorder: Systematic review and meta-analysis. Journal of Autism and Developmental Disorders, 48(5), 1483–1491. https://doi.org/10.1007/s10803-017-3412-x.

Magnusson, C., Kosidou, K., Dalman, C., Lundberg, M., Lee, B. K., Rai, D., et al. (2016). Maternal vitamin D deficiency and the risk of autism spectrum disorders: Population-based study. BJPsych Open, 2(02), 170–172. https://doi.org/10.1192/bjpo.bp.116.002675.

Meckel, K., Li, Y. C., Lim, J., Kocherginsky, M., Weber, C., Almoghrabi, A., et al. (2016). Serum 25-hydroxyvitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis. The American Journal of Clinical Nutrition, 104(1), 113–120. https://doi.org/10.3945/ajcn.115.123786.

Meguid, N. A., Hashish, A. F., Anwar, M., & Sidhom, G. (2010). Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism. The Journal of Alternative and Complementary Medicine, 16(6), 641–645. https://doi.org/10.1089/acm.2009.0349.

Nwosu, B. U., Maranda, L., & Candela, N. (2017). Vitamin D status in pediatric irritable bowel syndrome. PLoS ONE, 12(2), e0172183. https://doi.org/10.1371/journal.pone.0172183.

Ousley, O., & Cermak, T. (2014). Autism spectrum disorder: Defining dimensions and subgroups. Current Developmental Disorders Reports, 1(1), 20–28. https://doi.org/10.1007/s40474-013-0003-1.

Palacios, C., & Gonzalez, L. (2014). Is vitamin D deficiency a major global public health problem? The Journal of Steroid Biochemistry and Molecular Biology, 144(Pt A), 138–145. https://doi.org/10.1016/j.jsbmb.2013.11.003.

Palmieri, L., Papaleo, V., Porcelli, V., Scarcia, P., Gaita, L., Sacco, R., et al. (2010). Altered calcium homeostasis in autism-spectrum disorders: Evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Molecular Psychiatry, 15(1), 38–52. https://doi.org/10.1038/mp.2008.63.

Piton, A., Michaud, J. L., Peng, H., Aradhya, S., Gauthier, J., Mottron, L., et al. (2008). Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Human Molecular Genetics, 17(24), 3965–3974. https://doi.org/10.1093/hmg/ddn300.

Saad, K., Abdel-rahman, A. A., Elserogy, Y. M., Al-Atram, A. A., Cannell, J. J., Bjørklund, G., et al. (2016). Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutritional Neuroscience, 19(8), 346–351. https://doi.org/10.1179/1476830515Y.0000000019.

Saad, K., Abdel-Rahman, A. A., Elserogy, Y. M., Al-Atram, A. A., El-Houfey, A. A., Othman, H. A., et al. (2018). Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 59(1), 20–29. https://doi.org/10.1111/jcpp.12652.

Schaaf, C. P., & Zoghbi, H. Y. (2011). Solving the autism puzzle a few pieces at a time. Neuron, 70(5), 806–808. https://doi.org/10.1016/j.neuron.2011.05.025.

Tazzyman, S., Richards, N., Trueman, A. R., Evans, A. L., Grant, V. A., Garaiova, I., et al. (2015). Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: Outcomes from a pilot trial. BMJ Open Gastroenterology, 2(1), e000052. https://doi.org/10.1136/bmjgast-2015-000052.

Xu, G., Strathearn, L., Liu, B., & Bao, W. (2018). Prevalence of autism spectrum disorder among us children and adolescents, 2014-2016. JAMA, 319(1), 81. https://doi.org/10.1001/jama.2017.17812.

Ye, B. S., Leung, A. O. W., & Wong, M. H. (2017). The association of environmental toxicants and autism spectrum disorders in children. Environmental Pollution, 227, 234–242. https://doi.org/10.1016/j.envpol.2017.04.039.

Zhang, Y., Wu, S., Lu, R., Zhou, D., Zhou, J., Carmeliet, G., et al. (2015). Tight junction CLDN2 gene is a direct target of the vitamin D receptor. Scientific Reports, 5(1), 10642. https://doi.org/10.1038/srep10642.

Titel: The Association Between Serum Vitamin D3 Levels and Autism Among Jordanian Boys
Auteurs:: Loai Alzghoul
Laith N. AL-Eitan
Mohammad Aladawi
Maher Odeh
Osama Abu Hantash
Publicatiedatum: 16-04-2019
DOI: https://doi.org/10.1007/s10803-019-04017-w
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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