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01-02-2007 | Original Paper | Uitgave 2/2007

Risperidone Improves Behavioral Symptoms in Children with Autism in a Randomized, Double-Blind, Placebo-Controlled Trial

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 2/2007

Auteurs:: Gahan J. Pandina, Cynthia A. Bossie, Eriene Youssef, Young Zhu, Fiona Dunbar

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Abstract

Subgroup analysis of children (5–12 years) with autism enrolled in an 8-week, double-blind, placebo-controlled trial of risperidone for pervasive developmental disorders. The primary efficacy measure was the Aberrant Behavior Checklist-Irritability (ABC-I) subscale. Data were available for 55 children given risperidone (n = 27) or placebo (n = 28); mean baseline ABC-I ( ± SD) was 20.6 (8.1) and 21.6 (10.2). Risperidone [mean dose ( ± SD): 1.37 mg/day (0.7)] resulted in significantly greater reduction from baseline to endpoint in ABC-I versus placebo [mean change ( ± SD): −13.4 (1.5) vs. −7.2 (1.4), P < 0.05; ES = −0.7]. The most common adverse effect with risperidone was somnolence (74% vs. 7% with placebo). Risperidone treatment was well tolerated and significantly improved behavioral problems associated with autism.

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Titel: Risperidone Improves Behavioral Symptoms in Children with Autism in a Randomized, Double-Blind, Placebo-Controlled Trial
Auteurs:: Gahan J. Pandina
Cynthia A. Bossie
Eriene Youssef
Young Zhu
Fiona Dunbar
Publicatiedatum: 01-02-2007
DOI: https://doi.org/10.1007/s10803-006-0234-7
Uitgeverij: Kluwer Academic Publishers-Plenum Publishers
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 2/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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