Swipe om te navigeren naar een ander artikel
The online version of this article (doi:10.1007/s11136-017-1597-2) contains supplementary material, which is available to authorized users.
To examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence.
PHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6–18 years of age. QOL scores ranged from zero (least QOL) to 100 (highest QOL) in the following dimensions: combined QOL inventory (CQOLI), multi-dimensional vigor (MDV), general wellbeing (GWB), present functioning, and general cognitive functioning (CF). Multivariable linear regression models estimated HIV-related percent differences (β) in QOL scores and 95% confidence intervals (CI).
Compared to HUU CQOLI deficits ranged from 6.5 to 9.2% (95% CI −15.4, −1.6), GWB deficit ranged from 6.5 to 10.5% (95% CI −16.0, −1.3), MDV deficit ranged from 6.8 to 11.6% (95% CI −14.5, 0.9), and CF deficit ranged from 9.7 to 13.1% for PHIV children. QOL deficits of similar magnitude and direction in most domains were observed for PHIV compared to PHEU. However, self-reported indicators of GWB (β = −3.5; 95% CI −9.0, 2.0) and present functioning (β = 4.0; 95% CI −4.6, 12.5) were similar for PHIV compared to PHEU. QOL scores were generally similar for PHEU compared to HUU.
PHEU and HUU had similar QOL profile but PHIV predicted sustained deficits in multiple QOL domains. PHIV and PHEU children were similar with respect to general wellbeing and present functioning. Psychosocial and scholastic interventions in combination with HIV care are likely to improve QOL in PHIV.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Supplementary material 1 (DOCX 45 kb)11136_2017_1597_MOESM1_ESM.docx
WHO. (2014). WHO: Global update on the health sector response to HIV. Geneva: WHO.
UNAIDS. (2015). HIV and AIDS estimates. Geneva: UNAIDS.
Kuntawee, C., Fungladda, W., Kaewkungwal, J., Chanthavanich, P., & Chotpittayasunon, T. (2010). Social factors related to quality of life among HIV infected children in ubon Ratchathani Province, Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health, 41(5), 1136–1144. PubMed
Wiznia, A., Stanley, K., Krogstad, P., et al. (2000). Combination nucleoside analog reverse transcriptase inhibitor(s) plus nevirapine, nelfinavir, or ritonavir in stable antiretroviral therapy-experienced HIV-infected children: week 24 results of a randomized controlled trial-PACTG 377. Pediatric AIDS Clinical Trials Group 377 Study Team. AIDS Research and Human Retroviruses, 16(12), 1113–1121. CrossRefPubMed
McKinney, R. E., Jr., Johnson, G. M., Stanley, K., et al. (1998). A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy in children with symptomatic therapy-naive HIV-1 infection. The pediatric AIDS clinical trials group protocol 300 study team. The Journal of Pediatrics, 133(4), 500–508. CrossRefPubMed
Kline, M. W., Blanchard, S., Fletcher, C. V., et al. (1999). A phase I study of abacavir (1592U89) alone and in combination with other antiretroviral agents in infants and children with human immunodeficiency virus infection. AIDS Clinical Trials Group 330 Team. Pediatrics, 103(4), e47. CrossRefPubMed
Ganz, P. A., Coscarelli Schag, C. A., Kahn, B., Petersen, L., & Hirji, K. (1993). Describing the health-related quality of life impact of HIV infection: Findings from a study using the HIV overview of problems-evaluation system (HOPES). Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 2(2), 109–119. CrossRef
Nordenfelt, L. (1993). Quality of life, health and happiness. Avebury: Aldershot.
Levi, R., & Drotar, D. (1998). Critical issues and needs in health-related quality of life assessment of children and adolescents with chronic health conditions. In D. Drotar (Ed.), Measuring health-related quality of life in children and adolescents: Implications for research and practice (pp. 3–24). Mahwah: Lawrence Erlbaum Associates Publishers.
UNAIDS. (2013). Global report: UNAIDS report on the global AIDS epidemic 2013. Geneva: UNAIDS.
Banerjee, T., Pensi, T., & Banerjee, D. (2010). HRQoL in HIV-infected children using PedsQL 4.0 and comparison with uninfected children. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 19(6), 803–812. CrossRef
Cronbach, L. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16(3), 297–334. CrossRef
Tibshirani, R. (2011). Regression shrinkage and selection via the lasso: A retrospective. Journal of the Royal Statistical Society: Series B, 73, 273–282. CrossRef
Foster, S. B., Lu, M., Glaze, D. G., et al. (2012). Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection. Clinical Immunology (Orlando, Fla), 144(1), 13–23. CrossRef
Punpanich, W., Gorbach, P. M., & Detels, R. (2012). Impact of paediatric human immunodeficiency virus infection on children’s and caregivers’ daily functioning and well-being: A qualitative study. Child: Care, Health and Development, 38(5), 714–722.
Punpanich, W., Boon-Yasidhi, V., Chokephaibulkit, K., et al. (2010). Health-related quality of life of Thai children with HIV infection: a comparison of the Thai quality of life in children (ThQLC) with the pediatric quality of life inventory version 4.0 (PedsQL 4.0) generic core scales. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 19(10), 1509–1516. CrossRef
UBoSUaIII. (2012). Uganda demographic health survey (p. 2012). Kampala: UBOS and Calverton.
- Quality of life among perinatally HIV-affected and HIV-unaffected school-aged and adolescent Ugandan children: a multi-dimensional assessment of wellbeing in the post-HAART era
A. K. Nkwata
S. K. Zalwango
F. N. Kizza
J. N. Sekandi
P. M. Musoke
A. E. Ezeamama
- Springer International Publishing