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11-04-2017 | Uitgave 9/2017 Open Access

Quality of Life Research 9/2017

The impact of quality-of-life data in relative effectiveness assessments of new anti-cancer drugs in European countries

Tijdschrift:
Quality of Life Research > Uitgave 9/2017
Auteurs:
Sarah Kleijnen, Teresa Leonardo Alves, Kim Meijboom, Iga Lipska, Anthonius De Boer, Hubertus G. Leufkens, Wim G. Goettsch
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Electronic supplementary material

The online version of this article (doi:10.​1007/​s11136-017-1574-9) contains supplementary material, which is available to authorized users.

Abstract

Purpose

The aim of this study is to investigate the role of health-related quality-of-life (QoL) data in relative effectiveness assessments (REAs) of new anti-cancer drugs across European jurisdictions, during health technology assessment procedures.

Methods

Comparative analysis of guidelines and publicly available REAs in six European jurisdictions of anti-cancer drugs approved by EMA between 2011 and 2013.

Results

Fourteen anti-cancer drugs were included, adding up to 79 REAs. Whilst all guidelines state that QoL is a relevant endpoint to determine the relative effectiveness of new cancer drugs, QoL data were included in only 54% of the 79 reports and their impact on the recommendations was limited.

Conclusions

Whilst national guidelines recognize the relevance of QoL to determine the relative effectiveness of new anti-cancer drugs, this is not well-reflected in current assessments. Developing and implementing into REAs specific evidence requirements for QoL data would improve the use of this patient-centred outcome in future reimbursement and pricing decisions.

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