Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-01-2013 | Original Paper

Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study

Auteurs: Ousseny Zerbo, Ana-Maria Iosif, Cheryl Walker, Sally Ozonoff, Robin L. Hansen, Irva Hertz-Picciotto

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2013

Abstract

We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR’s (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).

vorige artikel Disseminating ASD Interventions: A Pilot Study of a Distance Learning Program for Parents and Professionals

volgende artikel Virtual Reality Social Cognition Training for Young Adults with High-Functioning Autism

Alleen toegankelijk voor geautoriseerde gebruikers

Abdallah, M. W., Larsen, N., Grove, J., Norgaard-Pedersen, B., Thorsen, P., Mortensen, E. L., et al. (2011). Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders. World Journal of Biology Psychiatry. doi:10.3109/15622975.2011.639803

Abdallah, M. W., Larsen, N., Grove, J., Norgaard-Pedersen, B., Thorsen, P., Mortensen, E. L., et al. (2012). Amniotic fluid chemokines and autism spectrum disorders: An exploratory study utilizing a Danish Historic Birth Cohort. Brain, Behavior, and Immunity, 26(1), 170–176.PubMedCrossRef

Ashdown, H., Dumont, Y., Ng, M., Poole, S., Boksa, P., & Luheshi, G. N. (2006). The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Molecular Psychiatry, 11(1), 47–55.PubMedCrossRef

Atladottir, H. O., Thorsen, P., Ostergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., et al. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(12), 1423–1430.PubMedCrossRef

Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M., et al. (2004a). Serologic evidence of prenatal influenza in the etiology of schizophrenia. Archives of General Psychiatry, 61(8), 774–780.PubMedCrossRef

Brown, A. S., Hooton, J., Schaefer, C. A., Zhang, H., Petkova, E., Babulas, V., et al. (2004b). Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. American Journal of Psychiatry, 161(5), 889–895.PubMedCrossRef

CDC. http://www.cdc.gov/flu/about/season/flu-season.htm. From CDC.

Chess, S. (1971). Autism in children with congenital rubella. Journal of autism and childhood schizophrenia, 1(1), 33–47.PubMedCrossRef

Conti, B., Tabarean, I., Andrei, C., & Bartfai, T. (2004). Cytokines and fever. Frontiers in Bioscience, 9, 1433–1449.PubMedCrossRef

Dassa, D., Takei, N., Sham, P. C., & Murray, R. M. (1995). No association between prenatal exposure to influenza and autism. Acta Psychiatrica Scandinavica, 92(2), 145–149.PubMedCrossRef

Deykin, E. Y., & MacMahon, B. (1979). Viral exposure and autism. American Journal of Epidemiology, 109(6), 628–638.PubMed

Edwards, M. J. (2006). Review: Hyperthermia and fever during pregnancy. Birth Defects Research. Part A, Clinical and Molecular Teratology, 76(7), 507–516.PubMedCrossRef

Gilmore, J. H., Fredrik Jarskog, L., Vadlamudi, S., & Lauder, J. M. (2004). Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development. Neuropsychopharmacology, 29(7), 1221–1229.PubMedCrossRef

Goetzl, L., Evans, T., Rivers, J., Suresh, M. S., & Lieberman, E. (2002). Elevated maternal and fetal serum interleukin-6 levels are associated with epidural fever. American Journal of Obstetrics and Gynecology, 187(4), 834–838.PubMedCrossRef

Goines, P. E., Croen, L. A., Braunschweig, D., Yoshida, C. K., Grether, J., Hansen, R., et al. (2011). Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: A case-control study. Molecular Autism, 2(1), 13.PubMedCrossRef

Grether, J. K., Croen, L. A., Anderson, M. C., Nelson, K. B., & Yolken, R. H. (2010). Neonatally measured immunoglobulins and risk of autism. Autism Research, 3(6), 323–332.PubMedCrossRef

Grether, J. K., & Nelson, K. B. (1997). Maternal infection and cerebral palsy in infants of normal birth weight. JAMA, 278(3), 207–211.PubMedCrossRef

Hertz-Picciotto, I., Croen, L. A., Hansen, R., Jones, C. R., van de Water, J., & Pessah, I. N. (2006). The CHARGE study: An epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives, 114(7), 1119–1125.PubMedCrossRef

Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., et al. (1989). Autism Diagnostic Interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19(3), 363–387.PubMedCrossRef

Libbey, J. E., Sweeten, T. L., McMahon, W. M., & Fujinami, R. S. (2005). Autistic disorder and viral infections. Journal for Neurovirology, 11(1), 1–10.CrossRef

Lieberman, E., Eichenwald, E., Mathur, G., Richardson, D., Heffner, L., & Cohen, A. (2000). Intrapartum fever and unexplained seizures in term infants. Pediatrics, 106(5), 983–988.PubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The Autism Diagnostic Observation Schedule-Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRef

Louie, J. K., Acosta, M., Jamieson, D. J., & Honein, M. A. (2009). Severe 2009 H1N1 influenza in pregnant and postpartum women in California. New England Journal of Medicine, 362(1), 27–35.PubMedCrossRef

Maimburg, R. D., & Vaeth, M. (2006). Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica, 114(4), 257–264.PubMedCrossRef

Martin, L. A., Ashwood, P., Braunschweig, D., Cabanlit, M., Van de Water, J., & Amaral, D. G. (2008). Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain, Behavior, and Immunity, 22(6), 806–816.PubMedCrossRef

Meyer, U., Schwendener, S., Feldon, J., & Yee, B. K. (2006). Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Experimental Brain Research, 173(2), 243–257.CrossRef

Moretti, M. E., Bar-Oz, B., Fried, S., & Koren, G. (2005). Maternal hyperthermia and the risk for neural tube defects in offspring: Systematic review and meta-analysis. Epidemiology, 16(2), 216–219.PubMedCrossRef

Mullen, E. M. (1995). Mullen Scales of Early Learning. Circle Pines MN: American Guidance Services Inc.

Netea, M. G., Kullberg, B. J., & Van der Meer, J. W. (2000). Circulating cytokines as mediators of fever. Clinical Infectious Diseases, 31(Suppl 5), S178–S184.PubMedCrossRef

O'Callaghan, M. E., MacLennan, A. H., Gibson, C. S., McMichael, G. L., Haan, E. A., Broadbent, J. L., et al. (2011). Epidemiologic associations with cerebral palsy. Obstet Gynecol, 118(3), 576–582.PubMedCrossRef

Patterson, P. H. (2002). Maternal infection and immune involvement in autism. Trends in Molecular Medicine, 17(7), 384–389.PubMedCrossRef

Patterson, P. H. (2011). Maternal infection and immune involvement in autism. Trends Molecular Medicine.

Ponzio, N. M., Servatius, R., Beck, K., Marzouk, A., & Kreider, T. (2007). Cytokine levels during pregnancy influence immunological profiles and neurobehavioral patterns of the offspring. Annals of the New York Academy of Sciences, 1107, 118–128.PubMedCrossRef

SAS. (2002). SAS (Statistical Analysis Software). 9.1.3 ed. Cary, NC; Statistical Analysis Software Institute.

Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003). Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. Journal of Neuroscience, 23(1), 297–302.PubMed

Smith, S. E., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007). Maternal immune activation alters fetal brain development through interleukin-6. Journal of Neuroscience, 27(40), 10695–10702.PubMedCrossRef

Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (1984). Vineland Adaptive Behavior Scales Interview Edition Expanded Form Manual. Circle Pines: American Guidance Services Inc.

Torres, A. R. (2003). Is fever suppression involved in the etiology of autism and neurodevelopmental disorders? BMC Pediatrics, 3, 9.PubMedCrossRef

Wilkerson, D. S., Volpe, A. G., Dean, R. S., & Titus, J. B. (2002). Perinatal complications as predictors of infantile autism. International Journal of Neuroscience, 112(9), 1085–1098.PubMedCrossRef

Yamashita, Y., Fujimoto, C., Nakajima, E., Isagai, T., & Matsuishi, T. (2003). Possible association between congenital cytomegalovirus infection and autistic disorder. Journal of Autism and Developmental Disorders, 33(4), 455–459.PubMedCrossRef

Zaretsky, M. V., Alexander, J. M., Byrd, W., & Bawdon, R. E. (2004). Transfer of inflammatory cytokines across the placenta. Obstetrics and Gynecology, 103(3), 546–550.PubMedCrossRef

Zhang, X., Lv, C.C., Tian, J., Miao, R. J., Xi, W., Hertz-Picciotto, I., et al. (2010). Prenatal and perinatal risk factors for autism in China. Journal of Autism and Developmental Disorders, 40(11), 1311–1321.PubMedCrossRef

Titel: Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study
Auteurs: Ousseny Zerbo
Ana-Maria Iosif
Cheryl Walker
Sally Ozonoff
Robin L. Hansen
Irva Hertz-Picciotto
Publicatiedatum: 01-01-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1540-x

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 1/2013

Predictive Value of Morphological Features in Patients with Autism versus Normal Controls

The Triple I Hypothesis: Taking Another(’s) Perspective on Executive Dysfunction in Autism

Books Received

The Role of Timing in Testing Nonverbal IQ in Children with ASD

A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABAA Receptors

E. Veronica Bliss and Genevieve Edmonds: A Self-Determined Future with Asperger Syndrome: Solution Focused Approach