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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-01-2013 | Original Paper

A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABA_A Receptors

Auteurs: Jing-Qiong Kang, Gregory Barnes

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2013

Abstract

Autism and epilepsy are common childhood neurological disorders with a great heterogeneity of clinical phenotypes as well as risk factors. There is a high co-morbidity of autism and epilepsy. The neuropathology of autism and epilepsy has similar histology implicating the processes of neurogenesis, neural migration, programmed cell death, and neurite outgrowth. Genetic advances have identified multiple molecules that participate in neural development, brain network connectivity, and synaptic function which are involved in the pathogenesis of autism and epilepsy. Mutations in GABA_A receptor subunit have been frequently associated with epilepsy, autism, and other neuropsychiatric disorders. In this paper, we address the hypothesis that functional deficiency of GABAergic signaling is a potential common molecular mechanism underpinning the co-morbidity of autism and epilepsy.

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Titel: A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABAA Receptors
Auteurs: Jing-Qiong Kang
Gregory Barnes
Publicatiedatum: 01-01-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1543-7

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