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17-03-2021 | Original Paper

Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children

Auteurs: Tomoko Horinouchi, Kaori Maeyama, Masashi Nagai, Masami Mizobuchi, Yasuko Takagi, Yuka Okada, Takeshi Kato, Mio Nishimura, Yoko Kawasaki, Mieko Yoshioka, Satoshi Takada, Hisayuki Matsumoto, Yuji Nakamachi, Jun Saegusa, Sachiyo Fukushima, Kazumichi Fujioka, Kazumi Tomioka, Hiroaki Nagase, Kandai Nozu, Kazumoto Iijima, Noriyuki Nishimura

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2022

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Abstract

Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.
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Literatuur
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Metagegevens
Titel
Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children
Auteurs
Tomoko Horinouchi
Kaori Maeyama
Masashi Nagai
Masami Mizobuchi
Yasuko Takagi
Yuka Okada
Takeshi Kato
Mio Nishimura
Yoko Kawasaki
Mieko Yoshioka
Satoshi Takada
Hisayuki Matsumoto
Yuji Nakamachi
Jun Saegusa
Sachiyo Fukushima
Kazumichi Fujioka
Kazumi Tomioka
Hiroaki Nagase
Kandai Nozu
Kazumoto Iijima
Noriyuki Nishimura
Publicatiedatum
17-03-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-04941-w

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