Skip to main content
Top
Gepubliceerd in:

30-04-2020 | Original Paper

Exploring Key Physiological System Profiles at Rest and the Association with Depressive Symptoms in Autism Spectrum Disorder

Auteurs: Rachael A. Muscatello, Justin Andujar, Julie L. Taylor, Blythe A. Corbett

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2021

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Depression is often associated with dysfunction in the hypothalamic–pituitary–adrenal (HPA) axis and autonomic nervous system (ANS). Individuals with autism spectrum disorder (ASD) may experience physiological dysregulation and psychological comorbidities; however, the extent to which the interactions between these systems predict internalizing symptoms in ASD has not been investigated. The study examined interactions with the HPA axis and ANS in 10–13-year-old children with ASD (n = 41) and typical development (TD; n = 46). The interrelated systems uniquely contributed to depressive symptoms in ASD above and beyond any system in isolation. A reciprocal, parasympathetic-dominant ANS was related to fewer affective symptoms in ASD. Findings highlight the importance of examining arousal across multiple systems to more precisely identify profiles associated with maladaptive psychiatric outcomes in ASD.
Literatuur
go back to reference Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms and profiles. VT: Burlington. Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms and profiles. VT: Burlington.
go back to reference Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Thousand Oaks, CA: SAGE Publications Inc. Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Thousand Oaks, CA: SAGE Publications Inc.
go back to reference Althaus, M., Mulder, L. J., Mulder, G., Aarnoudse, C. C., & Minderaa, R. B. (1999). Cardiac adaptivity to attention-demanding tasks in children with a pervasive developmental disorder not otherwise specified (PDD-NOS). Biological Psychiatry, 46(6), 799–809.CrossRef Althaus, M., Mulder, L. J., Mulder, G., Aarnoudse, C. C., & Minderaa, R. B. (1999). Cardiac adaptivity to attention-demanding tasks in children with a pervasive developmental disorder not otherwise specified (PDD-NOS). Biological Psychiatry, 46(6), 799–809.CrossRef
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington, DC: American Psychiatric Association.CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). Washington, DC: American Psychiatric Association.CrossRef
go back to reference Bauer, A. M., Quas, J. A., & Boyce, W. T. (2002). Associations between physiological reactivity and children's behavior: Advantages of a multisystem approach. Journal of Developmental and Behavioral Pediatrics: JDBP, 23(2), 102–113.CrossRef Bauer, A. M., Quas, J. A., & Boyce, W. T. (2002). Associations between physiological reactivity and children's behavior: Advantages of a multisystem approach. Journal of Developmental and Behavioral Pediatrics: JDBP, 23(2), 102–113.CrossRef
go back to reference Benarroch, E. E. (1993). The central autonomic network: Functional organization, dysfunction, and perspective. Mayo Clinic Proceedings, 68(10), 988–1001.CrossRef Benarroch, E. E. (1993). The central autonomic network: Functional organization, dysfunction, and perspective. Mayo Clinic Proceedings, 68(10), 988–1001.CrossRef
go back to reference Benarroch, E. E. (2004). Central autonomic control. In D. Robertson, I. Biaggioni, G. Burnstock, & P. A. Low (Eds.), Primer on the autonomic nervous system (2nd ed., pp. 17–19). Amsterdam: Elsevier Inc.CrossRef Benarroch, E. E. (2004). Central autonomic control. In D. Robertson, I. Biaggioni, G. Burnstock, & P. A. Low (Eds.), Primer on the autonomic nervous system (2nd ed., pp. 17–19). Amsterdam: Elsevier Inc.CrossRef
go back to reference Berntson, G. G., Bigger, J. T., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., et al. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34(6), 623–648.CrossRef Berntson, G. G., Bigger, J. T., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., et al. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34(6), 623–648.CrossRef
go back to reference Corbett, B. A. (2017). Examining stress and arousal across pubertal development in ASD. National Institute of Mental Health. Corbett, B. A. (2017). Examining stress and arousal across pubertal development in ASD. National Institute of Mental Health.
go back to reference Corbett, B. A., Mendoza, S., Wegelin, J. A., Carmean, V., & Levine, S. (2008). Variable cortisol circadian rhythms in children with autism and anticipatory stress. Journal of Psychiatry & Neuroscience, 33(3), 227–234. Corbett, B. A., Mendoza, S., Wegelin, J. A., Carmean, V., & Levine, S. (2008). Variable cortisol circadian rhythms in children with autism and anticipatory stress. Journal of Psychiatry & Neuroscience, 33(3), 227–234.
go back to reference Corbett, B. A., Muscatello, R. A., Tanguturi, Y., McGinn, E., & Ioannou, S. (2019). Pubertal development measurement in children with and without autism spectrum disorder: A comparison between physical exam, parent- and self-report. Journal of Autism and Developmental Disorders, 75(4), 594–613. https://doi.org/10.1007/s10803-019-04192-w.CrossRef Corbett, B. A., Muscatello, R. A., Tanguturi, Y., McGinn, E., & Ioannou, S. (2019). Pubertal development measurement in children with and without autism spectrum disorder: A comparison between physical exam, parent- and self-report. Journal of Autism and Developmental Disorders, 75(4), 594–613. https://​doi.​org/​10.​1007/​s10803-019-04192-w.CrossRef
go back to reference Dahl, R. E., Ryan, N. D., Puig-Antich, J., Nguyen, N. A., Al-Shabbout, M., Meyer, V. A., et al. (1991). 24-hour cortisol measures in adolescents with major depression: A controlled study. Biological Psychiatry, 30(1), 25–36.CrossRef Dahl, R. E., Ryan, N. D., Puig-Antich, J., Nguyen, N. A., Al-Shabbout, M., Meyer, V. A., et al. (1991). 24-hour cortisol measures in adolescents with major depression: A controlled study. Biological Psychiatry, 30(1), 25–36.CrossRef
go back to reference Daluwatte, C., Miles, J. H., Christ, S. E., Beversdorf, D. Q., Takahashi, T. N., & Yao, G. (2013). Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(8), 1910–1925.CrossRef Daluwatte, C., Miles, J. H., Christ, S. E., Beversdorf, D. Q., Takahashi, T. N., & Yao, G. (2013). Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(8), 1910–1925.CrossRef
go back to reference Efron, B., & Tibshirani, R. J. (1993). An introduction to the bootstrap. Boca Raton: Chapman & Hall/CRC.CrossRef Efron, B., & Tibshirani, R. J. (1993). An introduction to the bootstrap. Boca Raton: Chapman & Hall/CRC.CrossRef
go back to reference Ghaziuddin, M., Ghaziuddin, N., & Greden, J. (2002). Depression in persons with autism: Implications for research and clinical care. Journal of Autism and Developmental Disorders, 32(4), 299–306.CrossRef Ghaziuddin, M., Ghaziuddin, N., & Greden, J. (2002). Depression in persons with autism: Implications for research and clinical care. Journal of Autism and Developmental Disorders, 32(4), 299–306.CrossRef
go back to reference Guy, L., Souders, M., Bradstreet, L., DeLussey, C., & Herrington, J. D. (2014). Brief report: Emotion regulation and respiratory sinus arrhythmia in autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(10), 2614–2620.CrossRef Guy, L., Souders, M., Bradstreet, L., DeLussey, C., & Herrington, J. D. (2014). Brief report: Emotion regulation and respiratory sinus arrhythmia in autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(10), 2614–2620.CrossRef
go back to reference Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis. New York: Guilford Press. Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis. New York: Guilford Press.
go back to reference Hayes, A. F., & Matthes, J. (2009). Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations. Behavior Research Methods, 41(3), 924–936.CrossRef Hayes, A. F., & Matthes, J. (2009). Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations. Behavior Research Methods, 41(3), 924–936.CrossRef
go back to reference Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. European Heart Journal. Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. European Heart Journal.
go back to reference Heim, C., Ehlert, U., & Hellhammer, D. H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25(1), 1–35.CrossRef Heim, C., Ehlert, U., & Hellhammer, D. H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25(1), 1–35.CrossRef
go back to reference Herman, J. P., & Cullinan, W. E. (1997). Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis. Trends in Neurosciences, 20(2), 78–84.CrossRef Herman, J. P., & Cullinan, W. E. (1997). Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis. Trends in Neurosciences, 20(2), 78–84.CrossRef
go back to reference IBM Corp. Released. (2019). IBM SPSS statistics for windows, version 26.0. Armonk, NY: IBM Corp. IBM Corp. Released. (2019). IBM SPSS statistics for windows, version 26.0. Armonk, NY: IBM Corp.
go back to reference Johnson, P. O., & Fay, L. C. (1950). The Johnson-Neyman technique, its theory and application. Psychometrika, 15(4), 349–367.CrossRef Johnson, P. O., & Fay, L. C. (1950). The Johnson-Neyman technique, its theory and application. Psychometrika, 15(4), 349–367.CrossRef
go back to reference Kessler, R. C., Merikangas, K. R., & Wang, P. S. (2007). Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annual Review of Clinical Psychology, 3, 137–158.CrossRef Kessler, R. C., Merikangas, K. R., & Wang, P. S. (2007). Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annual Review of Clinical Psychology, 3, 137–158.CrossRef
go back to reference Kirschbaum, C., & Hellhammer, D. H. (1989). Salivary cortisol in psychobiological research: An overview. Neuropsychobiology, 22(3), 150–169.CrossRef Kirschbaum, C., & Hellhammer, D. H. (1989). Salivary cortisol in psychobiological research: An overview. Neuropsychobiology, 22(3), 150–169.CrossRef
go back to reference Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism diagnostic observation schedule, second edition (ADOS-2). Torrance, CA: Western Psychological Services. Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism diagnostic observation schedule, second edition (ADOS-2). Torrance, CA: Western Psychological Services.
go back to reference McEwen, B. S. (2003). Mood disorders and allostatic load. Biological Psychiatry, 54(3), 200–207.CrossRef McEwen, B. S. (2003). Mood disorders and allostatic load. Biological Psychiatry, 54(3), 200–207.CrossRef
go back to reference Porges, S. W., Macellaio, M., Stanfill, S. D., McCue, K., Lewis, G. F., Harden, E. R., … Heilman, K. J. (2013). Respiratory sinus arrhythmia and auditory processing in autism: Modifiable deficits of an integrated social engagement system? International Journal of Psychophysiology, 88(3), 261–270. Porges, S. W., Macellaio, M., Stanfill, S. D., McCue, K., Lewis, G. F., Harden, E. R., … Heilman, K. J. (2013). Respiratory sinus arrhythmia and auditory processing in autism: Modifiable deficits of an integrated social engagement system? International Journal of Psychophysiology88(3), 261–270.
go back to reference Rutter, M., Bailey, A., & Lord, C. (2003). The social communication questionnaire. Los Angeles: Western Psychological Services. Rutter, M., Bailey, A., & Lord, C. (2003). The social communication questionnaire. Los Angeles: Western Psychological Services.
go back to reference Schaaf, R. C., Benevides, T. W., Leiby, B. E., & Sendecki, J. A. (2015). Autonomic dysregulation during sensory stimulation in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(2), 461–472.CrossRef Schaaf, R. C., Benevides, T. W., Leiby, B. E., & Sendecki, J. A. (2015). Autonomic dysregulation during sensory stimulation in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(2), 461–472.CrossRef
go back to reference Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R., & van Doornen, L. J. (1990). Methodological guidelines for impedance cardiography. Psychophysiology, 27(1), 1–23.CrossRef Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R., & van Doornen, L. J. (1990). Methodological guidelines for impedance cardiography. Psychophysiology, 27(1), 1–23.CrossRef
go back to reference Shibao, C., & Okamoto, L. (2012). Agents potentiating sympathetic tone. In D. Robertson, I. Biaggioni, G. Burnstock, P. A. Low, & J. F. R. Paton (Eds.), Primer on the autonomic nervous system. Cambridge: Academic Press. Shibao, C., & Okamoto, L. (2012). Agents potentiating sympathetic tone. In D. Robertson, I. Biaggioni, G. Burnstock, P. A. Low, & J. F. R. Paton (Eds.), Primer on the autonomic nervous system. Cambridge: Academic Press.
go back to reference Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https://www.samhsa.gov/data/. Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https://​www.​samhsa.​gov/​data/​.
go back to reference Taylor, J. L., & Corbett, B. A. (2014). A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders. Psychoneuroendocrinology, 49, 207–228.CrossRef Taylor, J. L., & Corbett, B. A. (2014). A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders. Psychoneuroendocrinology, 49, 207–228.CrossRef
go back to reference Thayer, J. F., Smith, M., Rossy, L. A., Sollers, J. J., & Friedman, B. H. (1998). Heart period variability and depressive symptoms: Gender differences. Biological Psychiatry, 44(4), 304–306.CrossRef Thayer, J. F., Smith, M., Rossy, L. A., Sollers, J. J., & Friedman, B. H. (1998). Heart period variability and depressive symptoms: Gender differences. Biological Psychiatry, 44(4), 304–306.CrossRef
go back to reference Toichi, M., & Kamio, Y. (2003). Paradoxical autonomic response to mental tasks in autism. Journal of Autism and Developmental Disorders, 33(4), 417–426.CrossRef Toichi, M., & Kamio, Y. (2003). Paradoxical autonomic response to mental tasks in autism. Journal of Autism and Developmental Disorders, 33(4), 417–426.CrossRef
go back to reference Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: Psychological Corporation. Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: Psychological Corporation.
Metagegevens
Titel
Exploring Key Physiological System Profiles at Rest and the Association with Depressive Symptoms in Autism Spectrum Disorder
Auteurs
Rachael A. Muscatello
Justin Andujar
Julie L. Taylor
Blythe A. Corbett
Publicatiedatum
30-04-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04516-1

Andere artikelen Uitgave 1/2021

Journal of Autism and Developmental Disorders 1/2021 Naar de uitgave