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Journal of Autism and Developmental Disorders

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23-05-2020 | Original Paper

Dysbiosis of Gut Fungal Microbiota in Children with Autism Spectrum Disorders

Auteurs: Rong Zou, Yuezhu Wang, Mengmeng Duan, Min Guo, Qiang Zhang, Huajun Zheng

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2021

Abstract

In this study, we tested the feces of children with ASD and those of healthy children, and the overall changing of the gut fungal community was observed in ASD children compared with controls. However, there were no abundant fungi populations showed significant variations between the ASD and Control group both at phylum and class level. Among the 507 genera identified, Saccharomyces and Aspergillus showed significant differences between ASD (59.07%) and Control (40.36%), indicating that they may be involved in the abnormal gut fungal community structure of ASD. When analyzed at the species level, a decreased abundance in Aspergillus versicolor was observed while Saccharomyces cerevisiae was increased in children with ASD relative to controls. Overall, this study characterized the fungal microbiota profile of children with ASD and identified potential diagnostic species closely related to the immune response in ASD.

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Titel: Dysbiosis of Gut Fungal Microbiota in Children with Autism Spectrum Disorders
Auteurs: Rong Zou
Yuezhu Wang
Mengmeng Duan
Min Guo
Qiang Zhang
Huajun Zheng
Publicatiedatum: 23-05-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04543-y

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