TODO: Skip to main content
Top
Gepubliceerd in:

01-01-2009 | Original Paper

Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders

Auteurs: Jeremy Goldberg, George M. Anderson, Lonnie Zwaigenbaum, Geoffrey B. C. Hall, Claude Nahmias, Ann Thompson, Peter Szatmari

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2009

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior.
Literatuur
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Metagegevens
Titel
Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders
Auteurs
Jeremy Goldberg
George M. Anderson
Lonnie Zwaigenbaum
Geoffrey B. C. Hall
Claude Nahmias
Ann Thompson
Peter Szatmari
Publicatiedatum
01-01-2009
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-008-0604-4