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01-01-2009 | Original Paper | Uitgave 1/2009

Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 1/2009

Auteurs:: Jeremy Goldberg, George M. Anderson, Lonnie Zwaigenbaum, Geoffrey B. C. Hall, Claude Nahmias, Ann Thompson, Peter Szatmari

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Abstract

Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [¹⁸F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [¹⁸F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior.

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Titel: Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders
Auteurs:: Jeremy Goldberg
George M. Anderson
Lonnie Zwaigenbaum
Geoffrey B. C. Hall
Claude Nahmias
Ann Thompson
Peter Szatmari
Publicatiedatum: 01-01-2009
DOI: https://doi.org/10.1007/s10803-008-0604-4
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 1/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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