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Journal of Autism and Developmental Disorders

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01-01-2009 | Original Paper

Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders

Auteurs: Jeremy Goldberg, George M. Anderson, Lonnie Zwaigenbaum, Geoffrey B. C. Hall, Claude Nahmias, Ann Thompson, Peter Szatmari

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2009

Abstract

Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [¹⁸F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [¹⁸F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior.

vorige artikel Joint Engagement and the Emergence of Language in Children with Autism and Down Syndrome

volgende artikel The Use of Weighted Vests with Children with Autism Spectrum Disorders and Other Disabilities

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Titel: Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders
Auteurs: Jeremy Goldberg
George M. Anderson
Lonnie Zwaigenbaum
Geoffrey B. C. Hall
Claude Nahmias
Ann Thompson
Peter Szatmari
Publicatiedatum: 01-01-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0604-4

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