Effect of aging in human cortical pre- and postsynaptic serotonin binding sites
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Serotonergic and cholinergic modulation of functional brain connectivity: A comparison between young and older adults
2018, NeuroImageCitation Excerpt :There is little proof of differentiated effects of selective serotonin reuptake inhibitors (SSRIs) and AChEIs on subjective and cognitive measures between healthy young and older subjects (Dumont et al., 2005; Repantis et al., 2010; Vanlaar et al., 1995). However, during senescence 5-HT receptor density declines (Arranz et al., 1993) and the cholinergic system has been suggested to have diminished and more variable responsiveness (Bartus, 1979; Decker, 1987). Given a negative association of aging with neuromodulation and brain function, we anticipate that effects of the SSRI citalopram and the AChEI galantamine on resting state connectivity are more constrained in older compared to young subjects.
Which demographic variables are necessary to correct in neuroimaging studies of serotonin transporter availability? A SPECT study with [<sup>123</sup>I]ADAM
2015, Psychiatry Research - NeuroimagingCitation Excerpt :Also, the highly selective affinity of SERT as assessed with the [123I]ADAM radioligand mitigates against the possible confound of dual activity related to the dopamine transporter (DAT), which might otherwise influence the results, as DAT may be also influenced by age (Lavalaye et al., 2000). The influence of age on SERT was not conclusive in previous post-mortem (Allen et al., 1983; Arranz et al., 1993) or other in vivo neuroimaging studies (Dahlstrom et al., 2000; Buchert et al., 2006), and the lack of clarity may reflect limited sample sizes in previous studies and the use of different radioligands. In addition, the age range of the subject group may affect the results.
The serotonergic system in ageing and Alzheimer's disease
2012, Progress in NeurobiologyCitation Excerpt :Age-associated declines in 5-HT2A receptor density were also observed in the deep layer of motor cortex and the middle strata of the visual cortex in rhesus monkeys (Bigham and Lidow, 1995). Age-related decreases in the density of 5-HT2A receptor binding sites have also been measured in the frontal cortex and the hippocampus of humans (Arranz et al., 1993; Gross-Isseroff et al., 1990; Marcusson et al., 1984b). The decline in the density of 5-HT2A receptor density begins around the age of 60 years in humans and shows a negative correlation with advanced age, suggesting that comparatively greater receptor loss occurs at younger ages (Blin et al., 1993; Marcusson et al., 1984b; Rosier et al., 1996).
Neuroeconomics and aging: Neuromodulation of economic decision making in old age
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The study was supported by grants from the Swedish Medical Research Council (B92-12X-08648-04B), the Stohne Foundation, Centrala Forsoksdjursnamnden and Gamla Tjanarinnor, the Swedish Society for Medicine, and FIS (93/0318).