Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
References (36)
- et al.
J. Pediatrics
(1961) - et al.
Biochem. Med.
(1971) - et al.
J. Am. Acad. Child Psychiatry
(1985) - et al.
Life Sci.
(1988) - et al.
Biochim. Biophys. Acta
(1992) - et al.
Life Sci.
(1987) - et al.
Eur. J. Pharmacol.
(1984) - et al.
Clin. Chim. Acta
(1981) - et al.
Methods Enzymol.
(1974) - et al.
J. Biol. Chem.
(1951)
Anal. Biochem.
Life Sci.
Life Sci.
Arch. Gen. Psychiatry
J. Child Psychol. Psychiat.
J. Autism Dev. Disord.
Arch. Gen. Psychiatry
Biochem. Med.
Cited by (155)
What is the mechanism of loudness hyperacusis in autism?
2022, Medical HypothesesSerotonin in cortical development: implications for autism spectrum disorder
2020, Handbook of Behavioral NeuroscienceNeural Circuits for Social Cognition: Implications for Autism
2018, NeuroscienceThe serotonin system in autism spectrum disorder: From biomarker to animal models
2016, NeuroscienceCitation Excerpt :The potential mechanisms underlying platelet 5-HT levels have been explored both in ASD families and in the general population. Essentially, elevated 5-HT levels in platelets could be due to one of four mechanisms: increased 5-HT production by enterochromaffin cells in the intestine, increased uptake of 5-HT into the platelet, decreased metabolic breakdown of 5-HT, or altered platelet release (Cook et al., 1993a). Most studies have focused on the platelet, rather than on the source of 5-HT in the gut.
Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :A recent functional magnetic resonance imaging study by Daly et al. (2012) suggested significant differences in acute depletion of TRP modulated spatial-facial expressions of emotions by 5-HT between adult ASD and control subjects. Study with partial agonist of 5-HT2A receptor, 3H-lysergic acid diethylamide has revealed significant reduction in binding affinity of 5-HT2A receptor in first-degree relatives of hyperserotonemic as compared to that of normoserotonemic autistic children (Cook et al., 1993). Children with ASD are at higher risk to develop gastrointestinal (GI) problems (Ibrahim et al., 2009).