Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-11-2013 | Brief Report

Brief Report: Atypical Neuromagnetic Responses to Illusory Auditory Pitch in Children with Autism Spectrum Disorders

Auteurs: Jon Brock, Samantha Bzishvili, Melanie Reid, Michael Hautus, Blake W. Johnson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2013

Abstract

Atypical auditory perception is a widely recognised but poorly understood feature of autism. In the current study, we used magnetoencephalography to measure the brain responses of 10 autistic children as they listened passively to dichotic pitch stimuli, in which an illusory tone is generated by sub-millisecond inter-aural timing differences in white noise. Relative to control stimuli that contain no inter-aural timing differences, dichotic pitch stimuli typically elicit an object related negativity (ORN) response, associated with the perceptual segregation of the tone and the carrier noise into distinct auditory objects. Autistic children failed to demonstrate an ORN, suggesting a failure of segregation; however, comparison with the ORNs of age-matched typically developing controls narrowly failed to attain significance. More striking, the autistic children demonstrated a significant differential response to the pitch stimulus, peaking at around 50 ms. This was not present in the control group, nor has it been found in other groups tested using similar stimuli. This response may be a neural signature of atypical processing of pitch in at least some autistic individuals.

vorige artikel Brief Report: Do Service Dog Providers Placing Dogs with Children with Developmental Disabilities Use Outcome Measures and, If So, What Are they?

volgende artikel Commentary: The Motor Skills of 7–10 Year Old Children Diagnosed with ASD. Are the Comparison Groups and Assessments Being Used Appropriate for the Research Questions Being Asked?

In an earlier MEG study of dichotic pitch perception in adults, Johnson and Hautus (2010) failed to find evidence of lateralization of the ORN. However, these authors used stimuli in which the noise was lateralized to the opposite side of space to the tone, rather than being perceived centrally as in the current study.

Alain, C. (2007). Breaking the wave: Effects of attention and learning on concurrent sound perception. Hearing Research, 229(1–2), 225–236.PubMedCrossRef

Alcántara, J. I., Weisblatt, E. J. L., Moore, B. C. J., & Bolton, P. F. (2004). Speech-in-noise perception in high-functioning individuals with autism or Asperger’s syndrome. Journal of Child Psychology and Psychiatry, 45(6), 1107–1114.PubMedCrossRef

Baranek, G. (1999). Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors at 9–12 months of age. Journal of Autism and Developmental Disorders, 29, 213–224.PubMedCrossRef

Bonnel, A., McAdams, S., Smith, B., Berthiaume, C., Bertone, A., Ciocca, V., et al. (2010). Enhanced pure-tone pitch discrimination among persons with autism but not Asperger syndrome. Neuropsychologia, 48, 2465–2475.PubMedCrossRef

Bregman, A. S. (1990). Auditory scene analysis. The perceptual organization of sound. Cambridge, MA: The MIT Press.

Ceponiene, R., Lepistö, T., Shestakova, A., Vanhala, R., Alku, P., Naatanen, R., et al. (2003). Speech-sound-selective auditory impairment in children with autism: They can perceive but do not attend. Proceedings of the National Academy of Sciences of the United States of America, 100, 5567–5572.PubMedCrossRef

Cesaroni, L., & Garber, M. (1991). Exploring the experience of autism through firsthand accounts. Journal of Autism and Developmental Disorders, 21, 303–313.PubMedCrossRef

Dougherty, R. F., Cynader, M. S., Bjornson, B. H., Edgell, D., & Giaschi, D. E. (1998). Dichotic pitch: A new stimulus distinguishes normal and dyslexic auditory function. NeuroReport, 9(13), 3001–3005.PubMedCrossRef

Efron, B., & Tibshirani, R. J. (1993). An introduction to the bootstrap. New York: Chapman & Hall.

Ferri, R., Elia, M., Agarwal, N., Lanuzza, B., Musumeci, S. A., & Pennisi, G. (2003). The mismatch negativity and the P3a components of the auditory event-related potentials in autistic low-functioning subjects. Clinical Neurophysiology, 114, 1671–1680.PubMedCrossRef

Greenspan, S., & Weider, S. (1997). Developmental patterns and out-comes in infants and children with disorders in relating and communicating. A chart review of 200 cases of children with autistic spectrum diagnoses. Journal of Developmental and Learning Disorders, 1, 87–141.

Haesen, B., Boets, B., & Wagemans, J. (2011). A review of behavioural and electrophysiological studies on auditory processing and speech perception in autism spectrum disorders. Research in Autism Spectrum Disorders, 5, 701–714.CrossRef

Hautus, M. J., & Johnson, B. W. (2005). Object-related brain potentials associated with the perceptual segregation of a dichotically embedded pitch. Journal of the Acoustical Society of America, 117, 275–280.PubMedCrossRef

Jansson-Verkasalo, E., Ceponiene, R., Kielinen, M., Suominen, K., Jantti, V., Linna, S. L., et al. (2003). Deficient auditory processing in children with Asperger syndrome, as indexed by event-related potentials. Neuroscience Letters, 338, 197–200.PubMedCrossRef

Johnson. B. W. (2011). Processing of binaural information in human auditory cortex. In P. Strumillo (Ed.) Advances in sound localization, ISBN: 978-953-307-224-1, InTech, Available from: http://www.intechopen.com/articles/show/title/processing-of-binaural-information-in-human-auditory-cortex.

Johnson, B. W., & Hautus, M. J. (2010). Processing of binaural spatial information in human auditory cortex: Neuromagnetic responses to interaural timing and level differences. Neuropsychologia, 48(9), 2610–2619.PubMedCrossRef

Johnson, B. W., McArthur, G., Hautus, M., Reid, M., Brock, J., Castles, A., et al. (2013). Lateralized auditory brain function in children with normal reading ability and children with dyslexia. Neuropsychologia, 51, 633–641.PubMedCrossRef

Kado, H., Higuchi, M., Shimogawara, M., Haruta, Y., Adachi, Y., Kawai, J., et al. (1999). Magnetoencephalogram systems developed at KIT. IEEE Transactions on Applied Superconductivity, 9(2), 4057–4062.CrossRef

Khalfa, S., Bruneau, N., Roge, B., Georgieff, N., Veulliet, E., Adrien, J.-L., et al. (2004). Increased perception of loudness in autism. Hearing Research, 198, 87–92.PubMedCrossRef

Lepistö, T., Kuitunen, A., Sussman, E., Saalasti, S., Jansson-Verkasalo, E., Nieminen-von Wendt, T., et al. (2009). Auditory stream segregation in children with Asperger syndrome. Biological Psychology, 82, 301–307.PubMedCrossRef

Lepistö, T., Kujala, T., Vanhala, R., Alku, P., Huotilainen, M., & Naatanen, R. (2005). The discrimination of and orienting to speech and non-speech sounds in children with autism. Brain Research, 1066, 147–157.PubMedCrossRef

Oram Cardy, J. E., Ferrari, P., Flagg, E. J., Roberts, W., & Roberts, T. P. (2004). Prominence of M50 auditory evoked response over M100 in childhood and autism. NeuroReport, 15, 1867–1870.PubMedCrossRef

Ponton, C. W., Eggermont, J. J., Kwong, B., & Don, M. (2000). Maturation of human central auditory system activity: Evidence from multi-channel evoked potentials. Clinical Neurophysiology, 111, 220–236.PubMedCrossRef

Roberts, T. P., Khan, S. Y., Rey, M., Monroe, J. F., Cannon, K., Blaskey, L., et al. (2010). MEG detection of delayed auditory evoked responses in autism spectrum disorders: Towards an imaging biomarker for autism. Autism Research, 3, 8–18.PubMed

Rutter, M., Bailey, A., & Lord, C. (2003). SCQ: The Social Communication Questionnaire—Manual. Los Angeles, CA: Western Psychological Services.

Scherg, M., & Von Cramon, D. (1986). Evoked dipole source potentials of the human auditory cortex. Electroencephalography and Clinical Neurophysiology, 65(5), 344–360.PubMedCrossRef

Wiggin, L. D., Robins, D. L., Bakeman, R., & Adamson, L. B. (2009). Sensory abnormalities as distinguishing symptoms of autism spectrum disorders in young children. Journal of Autism and Developmental Disorders, 39, 1087–1091.CrossRef

Zatorre, R. J., & Gandour, J. T. (2008). Neural specializations for speech and pitch: Moving beyond the dichotomies. Philosophical Transactions of the Royal Society, B, Biological Sciences, 363, 1087–1104.CrossRef

Titel: Brief Report: Atypical Neuromagnetic Responses to Illusory Auditory Pitch in Children with Autism Spectrum Disorders
Auteurs: Jon Brock
Samantha Bzishvili
Melanie Reid
Michael Hautus
Blake W. Johnson
Publicatiedatum: 01-11-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1805-z

Andere artikelen Uitgave 11/2013

Intervention for Infants at Risk of Developing Autism: A Case Series

Original Paper

Receptive Vocabulary in Boys with Autism Spectrum Disorder: Cross-Sectional Developmental Trajectories

Original Paper

Measurement Tools and Target Symptoms/Skills Used to Assess Treatment Response for Individuals with Autism Spectrum Disorder

Original Paper

Autism and Phthalate Metabolite Glucuronidation

Original Paper

Erratum to: A Review of Technology-Based Interventions to Teach Academic Skills to Students with Autism Spectrum Disorder

Erratum

The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and Trends

Original Paper