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Research on Child and Adolescent Psychopathology

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01-08-2011

Association of ADAM10 and CAMK2A Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Auteurs: Xue-Qiu Jian, Ke-Sheng Wang, Tie-Jian Wu, Joel J. Hillhouse, Jerald E. Mullersman

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 6/2011

Abstract

Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p < 10⁻³), nine of which were located in known genes, including ADAM10 (rs383902, p = 0.00036) and CAMK2A (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer’s disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.

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American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.

Angold, A., & Costello, E. J. (1993). Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues. The American Journal of Psychiatry, 150, 1779–1791.PubMed

Anney, R. J., Lasky-Su, J., O’Dúshláine, C., Kenny, E., Neale, B. M., Mulligan, A., et al. (2008). Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B, 1369–1378.CrossRef

Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263–265.PubMedCrossRef

Begleiter, H., Reich, T., Hesselbrock, V., Porjesz, B., Li, T. K. S., Schuckit, M. A., et al. (1995). The collaborative study on the genetics of alcoholism. Alcohol Health and Research World, 19, 228–236.

Biederman, J., & Faraone, S. V. (2005). Attention-deficit hyperactivity disorder. Lancet, 366, 237–248.PubMedCrossRef

Biederman, J., Newcorn, J., & Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. The American Journal of Psychiatry, 148, 564–577.PubMed

Braun, J. M., Froehlich, T. E., Daniels, J. L., Dietrich, K. N., Hornung, R., Auinger, P., et al. (2008). Association of environmental toxicants and conduct disorder in U.S. children: NHANES 2001–2004. Environmental Health Perspectives, 116, 956–962.PubMedCrossRef

Bucholz, K. K., Cadoret, R., Cloninger, C. R., Dinwiddie, S. H., Hesselbrock, V. M., Nurnberger, J. I., Jr., et al. (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies on Alcohol, 55, 149–158.PubMed

Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K., et al. (2003). Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry, 44, 88–101.PubMedCrossRef

Carlson, G. A., & Cantwell, D. P. (1980). Unmasking masked depression in children and adolescents. The American Journal of Psychiatry, 137, 445–449.PubMed

Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.PubMedCrossRef

Caspi, A., Langley, K., Milne, B., Moffitt, T. E., O’Donovan, M., Owen, M. J., et al. (2008). A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 65, 203–210.PubMedCrossRef

Chen, C., Rainnie, D. G., Greene, R. W., & Tonegawa, S. (1994). Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science, 266, 291–294.PubMedCrossRef

Colciaghi, F., Borroni, B., Pastorino, L., Marcello, E., Zimmermann, M., Cattabeni, F., et al. (2002). [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients. Molecular Medicine, 8, 67–74.PubMed

Cytryn, L., & McKnew, D. H., Jr. (1972). Proposed classification of childhood depression. The American Journal of Psychiatry, 129, 149–155.PubMed

Deas, D., & Brown, E. S. (2006). Adolescent substance abuse and psychiatric comorbidities. The Journal of Clinical Psychiatry, 67, e02.PubMedCrossRef

Dick, D. M., Viken, R. J., Kaprio, J., Pulkkinen, L., Nurnberger, J. I. Jr., & Rose, R. J. (2002). Adolescent alcohol use and conduct disorder: Age 14 interview data from finnish twin STUDIES. Annual Meeting of the Behavior Genetics Association. Keystone, CO.

Dick, D. M., Li, T. K., Edenberg, H. J., Hesselbrock, V., Kramer, J., Kuperman, S., et al. (2004). A genome-wide screen for genes influencing conduct disorder. Molecular Psychiatry, 9, 81–86.PubMedCrossRef

Dick, D. M., Bierut, L., Hinrichs, A., Fox, L., Bucholz, K. K., Kramer, J., et al. (2006). The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behavior Genetics, 36, 577–590.PubMedCrossRef

Dick, D. M., Aliev, F., Krueger, R. F., Edwards, A., Agrawal, A., Lynskey, M., et al. (2010a). Genome-wide association study of conduct disorder symptomatology. Molecular Psychiatry, [Epub ahead of print]

Dick, D. M., Meyers, J., Aliev, F., Nurnberger, J., Jr., Kramer, J., Kuperman, S., et al. (2010b). Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B, 1179–1188.

Edenberg, H. J., Bierut, L. J., Boyce, P., Cao, M., Cawley, S., Chiles, R., et al. (2005). Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. BMC Genetics, 6(Suppl 1), S2.PubMedCrossRef

Endrass, J., Vetter, S., Gamma, A., Gallo, W. T., Rossegger, A., Urbaniok, F., et al. (2007). Are behavioral problems in childhood and adolescence associated with bipolar disorder in early adulthood? European Archives of Psychiatry and Clinical Neuroscience, 257, 217–221.PubMedCrossRef

Endres, K., & Fahrenholz, F. (2010). Upregulation of the alpha-secretase ADAM10–risk or reason for hope? The FEBS Journal, 277, 1585–1596.PubMedCrossRef

Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., et al. (2004). Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738–744.PubMedCrossRef

Gatta, L. B., Albertini, A., Ravid, R., & Finazzi, D. (2002). Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus. Neuroreport, 13, 2031–2033.PubMedCrossRef

Geerlings, M. I., Jonker, C., Bouter, L. M., Ader, H. J., & Schmand, B. (1999). Association between memory complaints and incident Alzheimer’s disease in elderly people with normal baseline cognition. The American Journal of Psychiatry, 156, 531–537.PubMed

Glatt, S. J., Faraone, S. V., & Tsuang, M. T. (2008). Psychiatric genetics: A primer. In J. W. Smoller, B. R. Sheidley, & M. T. Tsung (Eds.), Psychiatric genetics: Applications in clinical practice (pp. 3–26). Washington, DC: American Psychiatric Publishing, INC.

Goldstein, R. B., Prescott, C. A., & Kendler, K. S. (2001). Genetic and environemental factors in conduct problems and adult antisocial behavior among adult female twins. The Journal of Nervous and Mental Disease, 189, 201–209.PubMedCrossRef

Hay, D. F., Pawlby, S., Waters, C. S., Perra, O., & Sharp, D. (2010). Mothers’ antenatal depression and their children’s antisocial outcomes. Child Development, 81, 149–165.PubMedCrossRef

Hesselbrock, M., Easton, C., Bucholz, K. K., Schuckit, M., & Hesselbrock, V. (1999). A validity study of the SSAGA—a comparison with the SCAN. Addiction, 94, 1361–1370.PubMedCrossRef

Hicks, B. M., Krueger, R. F., Iacono, W. G., McGue, M., & Patrick, C. J. (2004). Family transmission and heritability of externalizing disorders: a twin-family study. Archives of General Psychiatry, 61, 922–928.PubMedCrossRef

Hoffmann, T., & Lange, C. (2006). P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R. Bioinformatics, 22, 3103–3105.PubMedCrossRef

Jonker, C., Geerlings, M. I., & Schmand, B. (2000). Are memory complaints predictive for dementia? A review of clinical and population-based studies. Internal Journal Geriatric Psychiatry, 15, 983–991.CrossRef

Jorissen, E., Prox, J., Bernreuther, C., Weber, S., Schwanbeck, R., Serneels, L., et al. (2010). The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. The Journal of Neuroscience, 30, 4833–4844.PubMedCrossRef

Kendler, K. S., Kuo, P. H., Webb, B. T., Kalsi, G., Neale, M. C., Sullivan, P. F., et al. (2006). A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. Alcoholism, Clinical and Experimental Research, 30, 1972–1977.PubMedCrossRef

Kim, M. S., Kim, J. J., & Kwon, J. S. (2001). Frontal P300 decrement and executive dysfunction in adolescents with conduct problems. Child Psychiatry and Human Development, 32, 93–106.PubMedCrossRef

Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., et al. (2009). Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Human Molecular Genetics, 18, 3987–3996.PubMedCrossRef

Koenen, K. C., Moffitt, T. E., Roberts, A. L., Martin, L. T., Kubzansky, L., Harrington, H., et al. (2009). Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. The American Journal of Psychiatry, 166, 50–57.PubMedCrossRef

Kovacs, M., & Pollock, M. (1995). Bipolar disorder and comorbid conduct disorder in childhood and adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 715–723.PubMedCrossRef

Kutcher, S. P., Marton, P., & Korenblum, M. (1989). Relationship between psychiatric illness and conduct disorder in adolescents. Canadian Journal of Psychiatry, 34, 526–529.

Lee, J. H., Flaquer, A., Stern, Y., Tycko, B., & Mayeux, R. (2004). Genetic influences on memory performance in familial Alzheimer disease. Neurology, 62, 414–421.PubMed

Lewis, C. M. (2002). Genetic association studies: design, analysis and interpretation. Briefings in Bioinformatics, 3, 146–153.PubMedCrossRef

Loeber, R., Burke, J. D., Lahey, B. B., Winters, A., & Zera, M. (2000). Oppositional defiant and conduct disorder: a review of the past 10 years, part I. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 1468–1484.PubMedCrossRef

Malmberg, K., Wargelius, H. L., Lichtenstein, P., Oreland, L., & Larsson, J. O. (2008). ADHD and Disruptive Behavior scores-associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents. BMC Psychiatry, 8, 28.PubMedCrossRef

Martínez, A., Mas, A., de las Heras, V., Arroyo, R., Fernández-Arquero, M., de la Concha, E. G., et al. (2005). Early B-cell Factor gene association with multiple sclerosis in the Spanish population. BMC Neurology, 5, 19.PubMedCrossRef

Monuteaux, M. C., Biederman, J., Doyle, A. E., Mick, E., & Faraone, S. V. (2009). Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 757–764.PubMedCrossRef

Nordmark, G., Kristjansdottir, G., Theander, E., Appel, S., Eriksson, P., Vasaitis, L., et al. (2010). Association of EBF1, FAM167A (C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren’s syndrome. Genes and Immunity, [Epub ahead of print].

Novak, G., Seeman, P., & Tallerico, T. (2006). Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression. Synapse, 59, 61–68.PubMedCrossRef

O’Connor, T. G., McGuire, S., Reiss, D., Hetherington, E. M., & Plomin, R. (1998). Co-occurrence of depressive symptoms and antisocial behavior in adolescence: a common genetic liability. Journal of Abnormal Psychology, 107, 27–37.PubMedCrossRef

O’Connor, T. G., Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. (1998). Genetic contributions to continuity, change, and co-occurrence of antisocial and depressive symptoms in adolescence. Journal of Child Psychology and Psychiatry, 39, 323–336.PubMedCrossRef

O’Leary, D., Jyringi, D., & Sedler, M. (2005). Childhood conduct problems, stages of Alzheimer’s disease, and physical aggression against caregivers. Internal Journal of Geriatric Psychiatry, 20, 401–405.CrossRef

Postina, R., Schroeder, A., Dewachter, I., Bohl, J., Schmitt, U., Kojro, E., et al. (2004). A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. The Journal of Clinical Investigation, 113, 1456–1464.PubMed

Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A., Bender, D., et al. (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics, 81, 559–575.PubMedCrossRef

Reich, T. (1996). A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). Alcoholism, Clinical and Experimental Research, 20, 133A–137A.PubMedCrossRef

Rhee, S. H., & Waldman, I. D. (2002). Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin, 128, 490–529.PubMedCrossRef

Rice, J. P., & Saccone, S. F. (2005). Alcoholism and related traits: A summary of group 13 contributions. Genetic Epidemiology, 29(Suppl 1), S96–S102.PubMedCrossRef

Rowe, R., Rijsdijk, F. V., Maughan, B., Eley, T. C., Hosang, G. M., & Eley, T. C. (2008). Heterogeneity in antisocial behaviours and comorbidity with depressed mood: a behavioural genetic approach. Journal of Child Psychology and Psychiatry, 49, 526–534.PubMedCrossRef

Ruano, D., Abecasis, G. R., Glaser, B., Lips, E. S., Cornelisse, L. N., de Jong, A. P., et al. (2010). Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability. American Journal of Human Genetics, 86, 113–125.PubMedCrossRef

Sakai, J. T., Young, S. E., Stallings, M. C., Timberlake, D., Smolen, A., Stetler, G. L., et al. (2006). Case-control and within-family tests for an association between conduct disorder and 5HTTLPR. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 141B, 825–832.CrossRef

Sakai, J. T., Lessem, J. M., Haberstick, B. C., Hopfer, C. J., Smolen, A., Ehringer, M. A., et al. (2007). Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample. Psychiatric Genetics, 17, 207–214.PubMedCrossRef

Sakai, J. T., Stallings, M. C., Crowley, T. J., Gelhorn, H. L., McQueen, M. B., & Ehringer, M. A. (2010). Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. Drug and Alcohol Dependence, 106, 199–203.PubMedCrossRef

Sengupta, S. M., Grizenko, N., Schmitz, N., Schwartz, G., Ben Amor, L., Bellingham, J., et al. (2006). COMT Val108/158Met gene variant, birth weight, and conduct disorder in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1363–1369.PubMedCrossRef

Shaffer, D. (1974). Suicide in childhood and early adolescence. Journal of Child Psychology and Psychiatry, 15, 275–291.PubMedCrossRef

Shamsie, J., & Hluchy, C. (1991). Youth with conduct disorder: a challenge to be met. Canadian Journal of Psychiatry, 36, 405–414.

Shirts, B. H., Kim, J. J., Reich, S., Dickerson, F. B., Yolken, R. H., Devlin, B., et al. (2007). Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk. Schizophrenia Research, 94, 342–353.PubMedCrossRef

Shuai, L., Chan, R. C., & Wang, Y. (2011). Executive function profile of chinese boys with attention-deficit hyperactivity disorder: different subtypes and comorbidity. Archives of Clinical Neuropsychology, 26, 120–132.PubMedCrossRef

Slutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A., Bucholz, K. K., Dunne, M. P., et al. (1997). Modeling genetic and environmental influences in the etiology of conduct disorder: a study of 2,682 adult twin pairs. Journal of Abnormal Psychology, 106, 266–279.PubMedCrossRef

Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993). Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics, 52, 506–516.PubMed

Stallings, M. C., Corley, R. P., Dennehey, B., Hewitt, J. K., Krauter, K. S., Lessem, J. M., et al. (2005). A genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence. Archives of General Psychiatry, 62, 1042–1051.PubMedCrossRef

Steiner, H. (1997). Practice parameters for the assessment and treatment of children and adolescents with conduct disorder. American Academy of Child and Adolescent Psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 122S–139S.PubMedCrossRef

Storey, J. D. (2002). A direct approach to false discovery rates. J R Stat Soc Series B Stat Methodol, 64, 479–498.CrossRef

Subbarao, A., Rhee, S. H., Young, S. E., Ehringer, M. A., Corley, R. P., & Hewitt, J. K. (2008). Common genetic and environmental influences on major depressive disorder and conduct disorder. Journal of Abnormal Child Psychology, 36, 433–444.PubMedCrossRef

Thapar, A., Langley, K., Fowler, T., Rice, F., Turic, D., Whittinger, N., et al. (2005). Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 62, 1275–1278.PubMedCrossRef

Tierney, M. C., Szalai, J. P., Snow, W. G., Fisher, R. H., Nores, A., Nadon, G., et al. (1996). Prediction of probable Alzheimer’s disease in memory-impaired patients: a prospective longitudinal study. Neurology, 46, 661–665.PubMed

True, W. R., Heath, A. C., Scherrer, J. F., Xian, H., Lin, N., Eisen, S. A., et al. (1999). Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. American Journal of Medical Genetics, 88, 391–397.PubMedCrossRef

Van Steen, K., & Lange, C. (2005). PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Human Genomics, 2, 67–69.PubMed

Wang, Y. J., Chen, G. H., Hu, X. Y., Lu, Y. P., Zhou, J. N., & Liu, R. Y. (2005). The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer’s disease and its links with AD-related pathology. Brain Research, 1031, 101–108.PubMedCrossRef

Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661–678.CrossRef

Widom, C. S., & Brzustowicz, L. M. (2006). MAOA and the “cycle of violence:” childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry, 60, 684–689.PubMedCrossRef

Willi-Monnerat, S., Migliavacca, E., Surdez, D., Delorenzi, M., Luthi-Carter, R., & Terskikh, A. V. (2008). Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivision. Molecular and Cellular Neuroscience, 37, 845–856.PubMedCrossRef

Wozniak, J., Biederman, J., Faraone, S. V., Blier, H., & Monuteaux, M. C. (2001). Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorder. Journal of Affective Disorder, 64, 121–131.CrossRef

Xing, G., Russell, S., Hough, C., O’Grady, J., Zhang, L., Yang, S., et al. (2002). Decreased prefrontal CaMKII alpha mRNA in bipolar illness. Neuroreport, 13, 501–505.PubMedCrossRef

Yang, P., Baker, K. A., & Hagg, T. (2006). The ADAMs family: coordinators of nervous system development, plasticity and repair. Progress in Neurobiology, 79, 73–94.PubMedCrossRef

Titel: Association of ADAM10 and CAMK2A Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies
Auteurs: Xue-Qiu Jian
Ke-Sheng Wang
Tie-Jian Wu
Joel J. Hillhouse
Jerald E. Mullersman
Publicatiedatum: 01-08-2011
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 6/2011
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-011-9524-4

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