Abstract
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
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Acknowledgements
The Collaborative Study on the Genetics of Alcoholism (COGA) (H Begleiter, SUNY HSCB, Principal Investigator; T Reich, Washington University, Co-Principal Investigator) includes eight different centers where data collection, analysis and/or storage takes place. The eight sites and Principal Investigator and Co-Investigators are: Indiana University (T-K Li, J Nurnberger Jr, PM Conneally, HJ Edenberg); University of Iowa (R Crowe, S Kuperman); University of California at San Diego (M Schuckit); University of Connecticut (V Hesselbrock); State University of New York, Health Sciences Center at Brooklyn (B Porjesz, H Begleiter); Washington University in St Louis (T Reich, CR Cloninger, J Rice, A Goate); Rutgers University (J Tischfield); and Southwest Foundation (L Almasy). This national collaborative study is supported by the NIH Grant U10AA08403 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Preparation of this manuscript was also supported by AA13358 (D Dick), K02-AA00285 (T Foroud), and MO1 RR6192 (V Hesselbrock).
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Dick, D., Li, TK., Edenberg, H. et al. A genome-wide screen for genes influencing conduct disorder. Mol Psychiatry 9, 81–86 (2004). https://doi.org/10.1038/sj.mp.4001368
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DOI: https://doi.org/10.1038/sj.mp.4001368
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