Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Research on Child and Adolescent Psychopathology 6/2011

01-08-2011

Serotonin Transporter Genotype Moderates the Link Between Children’s Reports of Overprotective Parenting and Their Behavioral Inhibition

Auteurs: Katie L. Burkhouse, Brandon E. Gibb, Meredith E. Coles, Valerie S. Knopik, John E. McGeary

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 6/2011

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The goal of the current study was to examine environmental and genetic correlates of children’s levels of behavioral inhibition (BI). Participants were 100 mother child pairs drawn from the community who were part of a larger study of the intergenerational transmission of depression. Results indicated that higher levels of maternal overprotection, as reported by the child, were associated with elevations in BI among children carrying two copies of the lower expressing 5-HTTLPR alleles (S or LG), but not among those carrying only one copy or those homozygous for the LA allele. In addition, this interaction was specific for the social component of BI, not the nonsocial component. This relation was maintained even after statistically controlling for children’s and mother’s psychopathology. Together, these findings add to emerging research demonstrating that G × E interactions predict variation in BI during childhood.
Voetnoten
1
Details of these analyses are available from the first author.
 
Literatuur
go back to reference American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author.
go back to reference Angold, A. (1989). Structured assessments of psychopathology in children and adolescents. Chichester: Wiley. Angold, A. (1989). Structured assessments of psychopathology in children and adolescents. Chichester: Wiley.
go back to reference Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897. PubMedCrossRef Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897. PubMedCrossRef
go back to reference Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory manual (2nd ed.). San Antonio: Psychological Corporation. Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory manual (2nd ed.). San Antonio: Psychological Corporation.
go back to reference Beesdo, K., Pine, D. S., Lieb, R., & Wittchen, H. (2010). Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Archives of General Psychiatry, 67, 47–57. PubMedCrossRef Beesdo, K., Pine, D. S., Lieb, R., & Wittchen, H. (2010). Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Archives of General Psychiatry, 67, 47–57. PubMedCrossRef
go back to reference Biederman, J., Rosenbaum, J. F., Hirshfeld, D. R., Faraone, S. V., Bolduc, E. A., Gersten, M., et al. (1990). Psychiatric correlates of behavioral inhibition in young children of parents with and without psychiatric disorders. Archives of General Psychiatry, 47, 21–26. PubMed Biederman, J., Rosenbaum, J. F., Hirshfeld, D. R., Faraone, S. V., Bolduc, E. A., Gersten, M., et al. (1990). Psychiatric correlates of behavioral inhibition in young children of parents with and without psychiatric disorders. Archives of General Psychiatry, 47, 21–26. PubMed
go back to reference Biederman, J., Rosenbaum, J. F., Bolduc-Murphy, E. A., Faraone, S. V., Chaloff, J., & Hirshfeld, D. R. (1993). A 3-year follow-up of children with and without behavioral inhibition. Journal of the American Academy of Child & Adolescent Psychiatry, 32, 814–821. CrossRef Biederman, J., Rosenbaum, J. F., Bolduc-Murphy, E. A., Faraone, S. V., Chaloff, J., & Hirshfeld, D. R. (1993). A 3-year follow-up of children with and without behavioral inhibition. Journal of the American Academy of Child & Adolescent Psychiatry, 32, 814–821. CrossRef
go back to reference Biederman, J., Hirshfeld-Becker, D. R., Rosenbaum, J. F., Herot, C., Friedman, D., & Snidman, N. (2001). Further evidence of association between behavioral inhibition and social anxiety in children. American Journal of Psychiatry, 158, 1673–1679. PubMedCrossRef Biederman, J., Hirshfeld-Becker, D. R., Rosenbaum, J. F., Herot, C., Friedman, D., & Snidman, N. (2001). Further evidence of association between behavioral inhibition and social anxiety in children. American Journal of Psychiatry, 158, 1673–1679. PubMedCrossRef
go back to reference Bogels, S., & Phares, V. (2008). Fathers’ role in the etiology, prevention and treatment of child anxiety: a review and new model. Clinical Psychology Review, 28, 539–558. PubMedCrossRef Bogels, S., & Phares, V. (2008). Fathers’ role in the etiology, prevention and treatment of child anxiety: a review and new model. Clinical Psychology Review, 28, 539–558. PubMedCrossRef
go back to reference Caspi, A., Moffitt, T. E., Newman, D. L., & Silva, P. A. (1996). Behavioral observations at age 3 years predict adult psychiatric disorders. Archives of General Psychiatry, 53, 1033–1039. PubMed Caspi, A., Moffitt, T. E., Newman, D. L., & Silva, P. A. (1996). Behavioral observations at age 3 years predict adult psychiatric disorders. Archives of General Psychiatry, 53, 1033–1039. PubMed
go back to reference Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509–527. PubMedCrossRef Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509–527. PubMedCrossRef
go back to reference Coles, M. E., Schofield, C. A., & Pietrefesa, A. S. (2006). Behavioral inhibition and obsessive–compulsive disorder. Journal of Anxiety Disorders, 20, 1118–1132. PubMedCrossRef Coles, M. E., Schofield, C. A., & Pietrefesa, A. S. (2006). Behavioral inhibition and obsessive–compulsive disorder. Journal of Anxiety Disorders, 20, 1118–1132. PubMedCrossRef
go back to reference Creamer, M., Foran, J., & Bell, R. (1995). The Beck Anxiety Inventory in a non-clinical sample. Behaviour Research and Therapy, 33, 477–485. PubMedCrossRef Creamer, M., Foran, J., & Bell, R. (1995). The Beck Anxiety Inventory in a non-clinical sample. Behaviour Research and Therapy, 33, 477–485. PubMedCrossRef
go back to reference De Los Reyes, A., & Kazdin, A. E. (2005). Informant discrepancies in the assessment of childhood psychopathology: a critical review, theoretical framework, and recommendations for further study. Psychological Bulletin, 131, 483–509. PubMedCrossRef De Los Reyes, A., & Kazdin, A. E. (2005). Informant discrepancies in the assessment of childhood psychopathology: a critical review, theoretical framework, and recommendations for further study. Psychological Bulletin, 131, 483–509. PubMedCrossRef
go back to reference DiLalla, L., Kagan, J., & Reznick, J. (1994). Genetic etiology of behavioral inhibition among 2-year-old children. Infant Behavior and Development, 17, 405–412. CrossRef DiLalla, L., Kagan, J., & Reznick, J. (1994). Genetic etiology of behavioral inhibition among 2-year-old children. Infant Behavior and Development, 17, 405–412. CrossRef
go back to reference Edelbrock, C., Costello, A. J., Dulcan, M. K., Conover, N. C., & Kala, R. (1986). Parent–child agreement on child psychiatric symptoms assessed via structured interview. Journal of Child Psychology and Psychiatry, 27(2), 181–190. PubMed Edelbrock, C., Costello, A. J., Dulcan, M. K., Conover, N. C., & Kala, R. (1986). Parent–child agreement on child psychiatric symptoms assessed via structured interview. Journal of Child Psychology and Psychiatry, 27(2), 181–190. PubMed
go back to reference Endicott, J., & Spitzer, R. L. (1978). A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837–844. PubMed Endicott, J., & Spitzer, R. L. (1978). A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837–844. PubMed
go back to reference Fox, N. A., Nichols, K. E., Henderson, H. A., Rubin, K., Schmidt, L., & Hamer, D. (2005). Evidence for a gene–environment interaction in predicting behavioral inhibition in middle childhood. Psychological Science, 16, 921–926. PubMedCrossRef Fox, N. A., Nichols, K. E., Henderson, H. A., Rubin, K., Schmidt, L., & Hamer, D. (2005). Evidence for a gene–environment interaction in predicting behavioral inhibition in middle childhood. Psychological Science, 16, 921–926. PubMedCrossRef
go back to reference Freeman, B., Powell, J., Ball, D., Hill, L., Craig, I., & Plomin, R. (1997). DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behavior Genetics, 27, 251–257. PubMedCrossRef Freeman, B., Powell, J., Ball, D., Hill, L., Craig, I., & Plomin, R. (1997). DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behavior Genetics, 27, 251–257. PubMedCrossRef
go back to reference Garcia-Coll, C., Kagan, J., & Reznick, J. S. (1984). Behavioral inhibition in young children. Child Development, 55, 1005–1019. CrossRef Garcia-Coll, C., Kagan, J., & Reznick, J. S. (1984). Behavioral inhibition in young children. Child Development, 55, 1005–1019. CrossRef
go back to reference Gaylord, N. K., Kitzmann, K. M., & Coleman, J. K. (2003). Parents’ and children’s perceptions of parental behavior: associations with children’s psychosocial adjustment in the classroom. Parenting: Science and Practice, 3, 23–47. Gaylord, N. K., Kitzmann, K. M., & Coleman, J. K. (2003). Parents’ and children’s perceptions of parental behavior: associations with children’s psychosocial adjustment in the classroom. Parenting: Science and Practice, 3, 23–47.
go back to reference Gibb, B. E., Urhlass, D. J., Grassia, M., Benas, J. S., & McGeary, J. (2009). Children’s inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: an integrated model for the intergenerational transmission of depression. Journal of Abnormal Psychology, 118, 734–745. PubMedCrossRef Gibb, B. E., Urhlass, D. J., Grassia, M., Benas, J. S., & McGeary, J. (2009). Children’s inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: an integrated model for the intergenerational transmission of depression. Journal of Abnormal Psychology, 118, 734–745. PubMedCrossRef
go back to reference Gladstone, G. L., Parker, G. B., Mitchell, P. B., Wilhelm, K. A., & Mali, G. S. (2005). Relationship between self-reported childhood behavioral inhibition and lifetime anxiety disorders in a clinical sample. Depression and Anxiety, 22, 103–113. PubMedCrossRef Gladstone, G. L., Parker, G. B., Mitchell, P. B., Wilhelm, K. A., & Mali, G. S. (2005). Relationship between self-reported childhood behavioral inhibition and lifetime anxiety disorders in a clinical sample. Depression and Anxiety, 22, 103–113. PubMedCrossRef
go back to reference Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847–851. PubMedCrossRef Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry, 63, 847–851. PubMedCrossRef
go back to reference Guo, S. W., & Thompson, E. A. (1992). Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics, 48, 361–372. PubMedCrossRef Guo, S. W., & Thompson, E. A. (1992). Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics, 48, 361–372. PubMedCrossRef
go back to reference Hayward, C., Killen, J. D., Kraemer, H. C., & Taylor, C. B. (1998). Linking self-reported childhood behavioral inhibition to adolescent social phobia. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 1308–1316. CrossRef Hayward, C., Killen, J. D., Kraemer, H. C., & Taylor, C. B. (1998). Linking self-reported childhood behavioral inhibition to adolescent social phobia. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 1308–1316. CrossRef
go back to reference Hirshfeld-Becker, D. R., Biederman, J., Henin, A., Faraone, S. V., Davis, S., & Harrington, K. (2007). Behavioral inhibition in preschool children at risk is a specific predictor of middle childhood social anxiety: a five year follow-up. Journal of Developmental and Behavioral Pediatrics, 28, 225–233. PubMedCrossRef Hirshfeld-Becker, D. R., Biederman, J., Henin, A., Faraone, S. V., Davis, S., & Harrington, K. (2007). Behavioral inhibition in preschool children at risk is a specific predictor of middle childhood social anxiety: a five year follow-up. Journal of Developmental and Behavioral Pediatrics, 28, 225–233. PubMedCrossRef
go back to reference Hirshfeld-Becker, D. R., Micco, J., Henin, A., Bloomfield, A., Biederman, J., & Rosenbaum, J. (2008). Behavioral inhibition. Depression and Anxiety, 25, 357–367. PubMedCrossRef Hirshfeld-Becker, D. R., Micco, J., Henin, A., Bloomfield, A., Biederman, J., & Rosenbaum, J. (2008). Behavioral inhibition. Depression and Anxiety, 25, 357–367. PubMedCrossRef
go back to reference Hirshfeld-Becker, D. R., Masek, B., Henin, A., Blakely, L. R., Pollock-Wurman, R. A., McQuade, J., et al. (2010). Cognitive behavioral therapy for 4- to 7-year-old children with anxiety disorders: a randomized clinical trial. Journal of Consulting and Clinical Psychology, 48, 498–510. CrossRef Hirshfeld-Becker, D. R., Masek, B., Henin, A., Blakely, L. R., Pollock-Wurman, R. A., McQuade, J., et al. (2010). Cognitive behavioral therapy for 4- to 7-year-old children with anxiety disorders: a randomized clinical trial. Journal of Consulting and Clinical Psychology, 48, 498–510. CrossRef
go back to reference Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D., & Schuckit, M. A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism: Clinical and Experimental Research, 29, 8–16. CrossRef Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D., & Schuckit, M. A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism: Clinical and Experimental Research, 29, 8–16. CrossRef
go back to reference Jaffee, S. R., Moffitt, T. E., Caspi, A., Fombonne, E., Poulton, R., & Martin, J. (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry, 58, 215–222. CrossRef Jaffee, S. R., Moffitt, T. E., Caspi, A., Fombonne, E., Poulton, R., & Martin, J. (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry, 58, 215–222. CrossRef
go back to reference Kagan, J., Reznick, J. S., Clarke, C., Snidman, N., & Garcia-Coll, C. (1984). Behavioral inhibition to the unfamiliar. Child Development, 55, 2212–2225. CrossRef Kagan, J., Reznick, J. S., Clarke, C., Snidman, N., & Garcia-Coll, C. (1984). Behavioral inhibition to the unfamiliar. Child Development, 55, 2212–2225. CrossRef
go back to reference Kagan, J., Snidman, N., Arcus, D., & Reznick, J. S. (1994). Galen’s prophecy: temperament in human nature. New York: Basic Books. Kagan, J., Snidman, N., Arcus, D., & Reznick, J. S. (1994). Galen’s prophecy: temperament in human nature. New York: Basic Books.
go back to reference Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression: meta-analysis revisited. Archives of General Psychiatry, 68, 444–454. PubMedCrossRef Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression: meta-analysis revisited. Archives of General Psychiatry, 68, 444–454. PubMedCrossRef
go back to reference Kaufman, J., Birmaher, B., Brent, D., & Rao, U. (1997). Schedule for affective disorders and schizophrenia for school-age children—present and lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980–988. CrossRef Kaufman, J., Birmaher, B., Brent, D., & Rao, U. (1997). Schedule for affective disorders and schizophrenia for school-age children—present and lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980–988. CrossRef
go back to reference Kendler, K. S. (1996). Parenting: A genetic–epidemiologic perspective. American Journal of Psychiatry, 153, 11–20. PubMed Kendler, K. S. (1996). Parenting: A genetic–epidemiologic perspective. American Journal of Psychiatry, 153, 11–20. PubMed
go back to reference Kochanska, G. (1991). Patterns of inhibition to the unfamiliar in children of normal and affectively ill mothers. Child Development, 62, 250–263. PubMedCrossRef Kochanska, G. (1991). Patterns of inhibition to the unfamiliar in children of normal and affectively ill mothers. Child Development, 62, 250–263. PubMedCrossRef
go back to reference Kovacs, M. (1981). Rating scales to assess depression in school-aged children. Acta Paedopsychiatrica, 46, 305–315. PubMed Kovacs, M. (1981). Rating scales to assess depression in school-aged children. Acta Paedopsychiatrica, 46, 305–315. PubMed
go back to reference Lench, N., Stanier, P., & Williamson, R. (1988). Simple non-invasive method to obtain DNA for gene analysis. Lancet, 1, 1356–1358. PubMedCrossRef Lench, N., Stanier, P., & Williamson, R. (1988). Simple non-invasive method to obtain DNA for gene analysis. Lancet, 1, 1356–1358. PubMedCrossRef
go back to reference Lesch, K. P., Bengel, D., Heils, A., Sabol, S., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531. PubMedCrossRef Lesch, K. P., Bengel, D., Heils, A., Sabol, S., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531. PubMedCrossRef
go back to reference Lizardi, H., & Klein, D. N. (2002). Evidence of increased sensitivity using a three-factor version of the parental bonding instrument. Journal of Nervous & Mental Disease, 190, 619–623. CrossRef Lizardi, H., & Klein, D. N. (2002). Evidence of increased sensitivity using a three-factor version of the parental bonding instrument. Journal of Nervous & Mental Disease, 190, 619–623. CrossRef
go back to reference Mick, M. A., & Telch, M. J. (1998). Social anxiety and history of behavioral inhibition in young adults. Journal of Anxiety Disorders, 12, 1–20. PubMedCrossRef Mick, M. A., & Telch, M. J. (1998). Social anxiety and history of behavioral inhibition in young adults. Journal of Anxiety Disorders, 12, 1–20. PubMedCrossRef
go back to reference Munafo, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J. (2003). Genetic polymorphism and personality in healthy adults: a systematic review and meta-analysis. Molecular Psychiatry, 8, 471–484. PubMedCrossRef Munafo, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J. (2003). Genetic polymorphism and personality in healthy adults: a systematic review and meta-analysis. Molecular Psychiatry, 8, 471–484. PubMedCrossRef
go back to reference Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biological Psychiatry, 63, 852–857. PubMedCrossRef Munafò, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biological Psychiatry, 63, 852–857. PubMedCrossRef
go back to reference Muris, P., & Steerneman, P. (2001). The revised version of the Screen for Child Anxiety Related Emotional Disorders (SCARED-R): first evidence for its reliability and validity in a clinical sample. British Journal of Clinical Psychology, 40, 35–44. PubMedCrossRef Muris, P., & Steerneman, P. (2001). The revised version of the Screen for Child Anxiety Related Emotional Disorders (SCARED-R): first evidence for its reliability and validity in a clinical sample. British Journal of Clinical Psychology, 40, 35–44. PubMedCrossRef
go back to reference Muris, P., Dreessen, L., Bogels, S., Weckx, M., & van Melick, M. (2004). A questionnaire for screening a broad range of DSM-defined anxiety disorder symptoms in clinically referred children and adolescents. Journal of Child Psychology and Psychiatry, 45, 813–820. PubMedCrossRef Muris, P., Dreessen, L., Bogels, S., Weckx, M., & van Melick, M. (2004). A questionnaire for screening a broad range of DSM-defined anxiety disorder symptoms in clinically referred children and adolescents. Journal of Child Psychology and Psychiatry, 45, 813–820. PubMedCrossRef
go back to reference Murphy, E., Brewin, C. R., & Silka, L. (1997). The assessment of parenting using the parental bonding instrument: two or three factors. Psychological Medicine, 27, 333–342. PubMedCrossRef Murphy, E., Brewin, C. R., & Silka, L. (1997). The assessment of parenting using the parental bonding instrument: two or three factors. Psychological Medicine, 27, 333–342. PubMedCrossRef
go back to reference Neal, J., Edelman, R. J., & Glachan, M. (2002). Behavioural inhibition and symptoms of anxiety and depression: is there a specific relationship with social phobia. British Journal of Clinical Psychology, 41, 274–361. CrossRef Neal, J., Edelman, R. J., & Glachan, M. (2002). Behavioural inhibition and symptoms of anxiety and depression: is there a specific relationship with social phobia. British Journal of Clinical Psychology, 41, 274–361. CrossRef
go back to reference Noller, P., & Callan, V. J. (1988). Understanding parent–adolescent interactions: perceptions of family members and outsiders. Developmental Psychology, 24, 707–714. CrossRef Noller, P., & Callan, V. J. (1988). Understanding parent–adolescent interactions: perceptions of family members and outsiders. Developmental Psychology, 24, 707–714. CrossRef
go back to reference Parker, G., Tupling, H., & Brown, L. B. (1979). A parental bonding instrument. British Journal of Medical Psychology, 52, 1–10. Parker, G., Tupling, H., & Brown, L. B. (1979). A parental bonding instrument. British Journal of Medical Psychology, 52, 1–10.
go back to reference Pooley, E. C., Houston, K., Hawton, K., & Harrison, P. J. (2003). Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene ( TPH A779C), but not with polymorphisms in five other sertonergic genes. Psychological Medicine, 33, 775–783. PubMedCrossRef Pooley, E. C., Houston, K., Hawton, K., & Harrison, P. J. (2003). Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene ( TPH A779C), but not with polymorphisms in five other sertonergic genes. Psychological Medicine, 33, 775–783. PubMedCrossRef
go back to reference Rapee, R. M. (1997). Potential role of child rearing practices in the development of anxiety and depression. Clinical Psychology Review, 17, 47–67. PubMedCrossRef Rapee, R. M. (1997). Potential role of child rearing practices in the development of anxiety and depression. Clinical Psychology Review, 17, 47–67. PubMedCrossRef
go back to reference Reznick, J. S., Hegeman, I. M., Kaufman, E. R., Woods, S. W., & Jacobs, M. (1992). Retrospective and concurrent self-report of behavioral inhibition and their relation to adult mental health. Development and Psychopathology, 4, 301–321. CrossRef Reznick, J. S., Hegeman, I. M., Kaufman, E. R., Woods, S. W., & Jacobs, M. (1992). Retrospective and concurrent self-report of behavioral inhibition and their relation to adult mental health. Development and Psychopathology, 4, 301–321. CrossRef
go back to reference Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association, 301, 2462–2471. PubMedCrossRef Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association, 301, 2462–2471. PubMedCrossRef
go back to reference Rosenbaum, J. F., Biederman, J., Hirshfeld, D. R., Bolduc, E. A., & Chaloff, J. (1991). Behavioral inhibition in children: a possible precursor to panic disorder or social phobia. Journal of Clinical Psychiatry, 52, 5–9. PubMed Rosenbaum, J. F., Biederman, J., Hirshfeld, D. R., Bolduc, E. A., & Chaloff, J. (1991). Behavioral inhibition in children: a possible precursor to panic disorder or social phobia. Journal of Clinical Psychiatry, 52, 5–9. PubMed
go back to reference Rubin, K. H., Hastings, P. D., Stewart, S. L., Henderson, H. A., & Chen, X. (1997). The consistency and concomitants of inhibition: some of the children, all of the time. Child Development, 68, 467–483. PubMedCrossRef Rubin, K. H., Hastings, P. D., Stewart, S. L., Henderson, H. A., & Chen, X. (1997). The consistency and concomitants of inhibition: some of the children, all of the time. Child Development, 68, 467–483. PubMedCrossRef
go back to reference Rubin, K. H., Cheah, C. S., & Fox, N. A. (2001). Emotion regulation, parenting, and display of social reticence in preschoolers. Early Education and Development, 12, 97–115. CrossRef Rubin, K. H., Cheah, C. S., & Fox, N. A. (2001). Emotion regulation, parenting, and display of social reticence in preschoolers. Early Education and Development, 12, 97–115. CrossRef
go back to reference Rubin, K. H., Burgess, K. B., & Hastings, P. D. (2002). Stability and social-behavioral consequences of toddlers’ inhibited temperament and parenting behaviors. Child Development, 73, 483–495. PubMedCrossRef Rubin, K. H., Burgess, K. B., & Hastings, P. D. (2002). Stability and social-behavioral consequences of toddlers’ inhibited temperament and parenting behaviors. Child Development, 73, 483–495. PubMedCrossRef
go back to reference Schmidt, L. A., Fox, N. A., Rubin, K. H., Hu, S., & Hamer, D. H. (2002). Molecular genetics of shyness and aggression in preschoolers. Personality and Individual Differences, 33, 227–238. CrossRef Schmidt, L. A., Fox, N. A., Rubin, K. H., Hu, S., & Hamer, D. H. (2002). Molecular genetics of shyness and aggression in preschoolers. Personality and Individual Differences, 33, 227–238. CrossRef
go back to reference Schofield, C. A., Coles, M. E., & Gibb, B. E. (2009). Retrospective reports of behavioral inhibition and young adults’ current symptoms of social anxiety, depression, and anxious arousal. Journal of Anxiety Disorders, 23, 884–890. PubMedCrossRef Schofield, C. A., Coles, M. E., & Gibb, B. E. (2009). Retrospective reports of behavioral inhibition and young adults’ current symptoms of social anxiety, depression, and anxious arousal. Journal of Anxiety Disorders, 23, 884–890. PubMedCrossRef
go back to reference Schwartz, C. E., Snidman, N., & Kagan, J. (1999). Adolescent social anxiety as an outcome of inhibited temperament in childhood. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 1008–1015. CrossRef Schwartz, C. E., Snidman, N., & Kagan, J. (1999). Adolescent social anxiety as an outcome of inhibited temperament in childhood. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 1008–1015. CrossRef
go back to reference Schwarz, J. C., Barton-Henry, M. L., & Pruzinsky, T. (1985). Assessing child-rearing behaviors: a comparison of ratings made by mother, father, child and sibling on the CRPBI. Child Development, 56, 462–479. PubMedCrossRef Schwarz, J. C., Barton-Henry, M. L., & Pruzinsky, T. (1985). Assessing child-rearing behaviors: a comparison of ratings made by mother, father, child and sibling on the CRPBI. Child Development, 56, 462–479. PubMedCrossRef
go back to reference Smucker, M. R., Craighead, W. E., Craighead, L. W., & Green, B. J. (1986). Normative and reliability data for the children’s depression inventory. Journal of Abnormal Child Psychology, 14, 25–39. PubMedCrossRef Smucker, M. R., Craighead, W. E., Craighead, L. W., & Green, B. J. (1986). Normative and reliability data for the children’s depression inventory. Journal of Abnormal Child Psychology, 14, 25–39. PubMedCrossRef
go back to reference Van Ameringen, M., Mancini, C., & Oakman, J. M. (1998). The relationship of behavioral inhibition and shyness to anxiety disorder. Journal of Nervous & Mental Disease, 186, 425–431. CrossRef Van Ameringen, M., Mancini, C., & Oakman, J. M. (1998). The relationship of behavioral inhibition and shyness to anxiety disorder. Journal of Nervous & Mental Disease, 186, 425–431. CrossRef
go back to reference Weissman, M., Orvaschel, H., & Padian, N. (1980). Children’s symptom and social functioning self-report scales. Comparison of mothers’ and children’s reports. The Journal of Nervous and Mental Disease, 168, 736–740. PubMedCrossRef Weissman, M., Orvaschel, H., & Padian, N. (1980). Children’s symptom and social functioning self-report scales. Comparison of mothers’ and children’s reports. The Journal of Nervous and Mental Disease, 168, 736–740. PubMedCrossRef
go back to reference Wendland, J. R., Martin, B. J., Kruse, M. R., Lesch, K.-P., & Murphy, D. L. (2006). Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry, 11, 224–226. PubMedCrossRef Wendland, J. R., Martin, B. J., Kruse, M. R., Lesch, K.-P., & Murphy, D. L. (2006). Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry, 11, 224–226. PubMedCrossRef
go back to reference Zalsman, G., Huang, Y., Oquendo, M. A., Burke, A. K., Hu, X., Brent, D. A., et al. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. American Journal of Psychiatry, 163, 1588–1593. PubMedCrossRef Zalsman, G., Huang, Y., Oquendo, M. A., Burke, A. K., Hu, X., Brent, D. A., et al. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. American Journal of Psychiatry, 163, 1588–1593. PubMedCrossRef
Metagegevens
Titel
Serotonin Transporter Genotype Moderates the Link Between Children’s Reports of Overprotective Parenting and Their Behavioral Inhibition
Auteurs
Katie L. Burkhouse
Brandon E. Gibb
Meredith E. Coles
Valerie S. Knopik
John E. McGeary
Publicatiedatum
01-08-2011
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 6/2011
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-011-9526-2