07-10-2022 | S:I: .Developmental Approach and Targeted Treatment of Sensory Alterations
Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia
Auteurs:
Sarah M. Haigh, Laura Van Key, Pat Brosseau, Shaun M. Eack, David I. Leitman, Dean F. Salisbury, Marlene Behrmann
Gepubliceerd in:
Journal of Autism and Developmental Disorders
|
Uitgave 12/2023
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Abstract
Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.