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Gepubliceerd in: Journal of Autism and Developmental Disorders 12/2023

07-10-2022 | S:I: .Developmental Approach and Targeted Treatment of Sensory Alterations

Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia

Auteurs: Sarah M. Haigh, Laura Van Key, Pat Brosseau, Shaun M. Eack, David I. Leitman, Dean F. Salisbury, Marlene Behrmann

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2023

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Abstract

Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.
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Metagegevens
Titel
Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia
Auteurs
Sarah M. Haigh
Laura Van Key
Pat Brosseau
Shaun M. Eack
David I. Leitman
Dean F. Salisbury
Marlene Behrmann
Publicatiedatum
07-10-2022
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-022-05771-0

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