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Gepubliceerd in: Journal of Autism and Developmental Disorders 12/2023

12-10-2022 | Original Paper

The Importance of Language Delays as an Early Indicator of Subsequent ASD Diagnosis in Public Healthcare Settings

Auteurs: Tanya Nitzan, Judah Koller, Michal Ilan, Michal Faroy, Analya Michaelovski, Idan Menashe, Gal Meiri, Ilan Dinstein

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2023

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Abstract

Previous studies have reported that ASD children with more severe symptoms are diagnosed earlier. However, previous studies in community settings have mostly relied on retrospective parental reports without the use of quantitative standardized test scores. Here, we evaluated the association of language, cognitive, and ASD severity standardized scores with the age of diagnosis in 1-6-year-old children diagnosed in a public healthcare setting. The results revealed that language scores were the strongest variable associated with the age of diagnosis, explaining ~ 30% of the variability across children. Indeed, all children diagnosed before 30-months of age exhibited moderate-to-severe language delays. These results further substantiate the prominence of language delay as a highly visible symptom associated with earlier ASD diagnosis in community clinical settings.
Literatuur
go back to reference Bayley, N. (2006). Bayley scales of infant and toddler development (3rd ed.).). San Antonio, TX: Harcourt Assessment Bayley, N. (2006). Bayley scales of infant and toddler development (3rd ed.).). San Antonio, TX: Harcourt Assessment
go back to reference Constantino, J. N., Abbacchi, A. M., Saulnier, C., Klaiman, C., Mandell, D. S., Zhang, Y., Hawks, Z., Bates, J., Klin, A., Shattuck, P., Molholm, S., Fitzgerald, R., Roux, A., Lowe, J. K., & Geschwind, D. H. (2020). Timing of the diagnosis of autism in african American children. Pediatrics, 146(3), https://doi.org/10.1542/PEDS.2019-3629 Constantino, J. N., Abbacchi, A. M., Saulnier, C., Klaiman, C., Mandell, D. S., Zhang, Y., Hawks, Z., Bates, J., Klin, A., Shattuck, P., Molholm, S., Fitzgerald, R., Roux, A., Lowe, J. K., & Geschwind, D. H. (2020). Timing of the diagnosis of autism in african American children. Pediatrics, 146(3), https://​doi.​org/​10.​1542/​PEDS.​2019-3629
go back to reference Dinstein, I., Arazi, A., Golan, H. M., Koller, J., Elliott, E., Gozes, I., Shulman, C., Shifman, S., Raz, R., Davidovitch, N., Gev, T., Aran, A., Stolar, O., Ben-Itzchak, E., Snir, I. M., Israel-Yaacov, S., Bauminger-Zviely, N., Bonneh, Y. S., Gal, E., & Meiri, G. (2020). The National Autism Database of Israel: a Resource for Studying Autism Risk Factors, Biomarkers, Outcome Measures, and Treatment Efficacy. Journal of Molecular Neuroscience, 70(9), 1303–1312. https://doi.org/10.1007/s12031-020-01671-zCrossRefPubMed Dinstein, I., Arazi, A., Golan, H. M., Koller, J., Elliott, E., Gozes, I., Shulman, C., Shifman, S., Raz, R., Davidovitch, N., Gev, T., Aran, A., Stolar, O., Ben-Itzchak, E., Snir, I. M., Israel-Yaacov, S., Bauminger-Zviely, N., Bonneh, Y. S., Gal, E., & Meiri, G. (2020). The National Autism Database of Israel: a Resource for Studying Autism Risk Factors, Biomarkers, Outcome Measures, and Treatment Efficacy. Journal of Molecular Neuroscience, 70(9), 1303–1312. https://​doi.​org/​10.​1007/​s12031-020-01671-zCrossRefPubMed
go back to reference Hagan, J. F., Shaw, J. S., & Duncan, P. M. (2007). American Academy of Pediatrics. Bright futures: Guidelines for health supervision of infants, children, and adolescents. Am Acad Pediatrics Hagan, J. F., Shaw, J. S., & Duncan, P. M. (2007). American Academy of Pediatrics. Bright futures: Guidelines for health supervision of infants, children, and adolescents. Am Acad Pediatrics
go back to reference Harrop, C., Libsack, E., Bernier, R., Dapretto, M., Jack, A., McPartland, J. C., Van Horn, J. D., Webb, S. J., Pelphrey, K., Aylward, E., Bernier, R. A., Bookheimer, S. Y., Gaab, N., Geschwind, D. H., Nelson, C. A., Pelphrey, K. A., Ankenman, K., Corrigan, S., Depedro-Mercier, D., & Wolf, J. (2021). Do Biological Sex and Early Developmental Milestones Predict the Age of First Concerns and Eventual Diagnosis in Autism Spectrum Disorder? Autism Research: Official Journal of the International Society for Autism Research, 14(1), 156–168. https://doi.org/10.1002/AUR.2446CrossRefPubMed Harrop, C., Libsack, E., Bernier, R., Dapretto, M., Jack, A., McPartland, J. C., Van Horn, J. D., Webb, S. J., Pelphrey, K., Aylward, E., Bernier, R. A., Bookheimer, S. Y., Gaab, N., Geschwind, D. H., Nelson, C. A., Pelphrey, K. A., Ankenman, K., Corrigan, S., Depedro-Mercier, D., & Wolf, J. (2021). Do Biological Sex and Early Developmental Milestones Predict the Age of First Concerns and Eventual Diagnosis in Autism Spectrum Disorder? Autism Research: Official Journal of the International Society for Autism Research, 14(1), 156–168. https://​doi.​org/​10.​1002/​AUR.​2446CrossRefPubMed
go back to reference Lense, M., Mitchell, E., Hall, C., & Klaiman, C. (2014). Assessment of Cognitive and Language Abilities in Toddlers with and without Autism Spectrum Disorders: Comparison of the Mullen Scales of Early Learning and the Bayley Scales of Infant and Toddler Development, 3rd Edition Lense, M., Mitchell, E., Hall, C., & Klaiman, C. (2014). Assessment of Cognitive and Language Abilities in Toddlers with and without Autism Spectrum Disorders: Comparison of the Mullen Scales of Early Learning and the Bayley Scales of Infant and Toddler Development, 3rd Edition
go back to reference Lord, C., Rutter, M., Di Lavore, P., Risi, S., Gotham, K., & Bishop, S. (2012). Autism and Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual (Part I): Modules 1–4. Western Psychological Services Lord, C., Rutter, M., Di Lavore, P., Risi, S., Gotham, K., & Bishop, S. (2012). Autism and Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual (Part I): Modules 1–4. Western Psychological Services
go back to reference Luiselli, J., Happé, F., Hurst, H., Freeman, S., Goldstein, G., Mazefsky, C., & Newman, D. B. (2013). Wechsler preschool and primary scale of intelligence. F. R. En Volkmar (Ed.), Ecyclopedia of Autism Spectrum Disorders. New York, NY: Springer Luiselli, J., Happé, F., Hurst, H., Freeman, S., Goldstein, G., Mazefsky, C., & Newman, D. B. (2013). Wechsler preschool and primary scale of intelligence. F. R. En Volkmar (Ed.), Ecyclopedia of Autism Spectrum Disorders. New York, NY: Springer
go back to reference Marrus, N., Hall, L. P., Paterson, S. J., Elison, J. T., Wolff, J. J., Swanson, M. R., Parish-Morris, J., Eggebrecht, A. T., Pruett, J. R., Hazlett, H. C., Zwaigenbaum, L., Dager, S., Estes, A. M., Schultz, R. T., Botteron, K. N., Piven, J., & Constantino, J. N. (2018). Language delay aggregates in toddler siblings of children with autism spectrum disorder. Journal of Neurodevelopmental Disorders, 10(1), 1–16. https://doi.org/10.1186/S11689-018-9247-8CrossRef Marrus, N., Hall, L. P., Paterson, S. J., Elison, J. T., Wolff, J. J., Swanson, M. R., Parish-Morris, J., Eggebrecht, A. T., Pruett, J. R., Hazlett, H. C., Zwaigenbaum, L., Dager, S., Estes, A. M., Schultz, R. T., Botteron, K. N., Piven, J., & Constantino, J. N. (2018). Language delay aggregates in toddler siblings of children with autism spectrum disorder. Journal of Neurodevelopmental Disorders, 10(1), 1–16. https://​doi.​org/​10.​1186/​S11689-018-9247-8CrossRef
go back to reference Meiri, G., Dinstein, I., Michaelowski, A., Flusser, H., Ilan, M., Faroy, M., Bar-Sinai, A., Manelis, L., Stolowicz, D., Yosef, L. L., Davidovitch, N., Golan, H., Arbelle, S., & Menashe, I. (2017). The Negev hospital-university-based (HUB) autism database. BioRxiv, 103770. https://doi.org/10.1101/103770 Meiri, G., Dinstein, I., Michaelowski, A., Flusser, H., Ilan, M., Faroy, M., Bar-Sinai, A., Manelis, L., Stolowicz, D., Yosef, L. L., Davidovitch, N., Golan, H., Arbelle, S., & Menashe, I. (2017). The Negev hospital-university-based (HUB) autism database. BioRxiv, 103770. https://​doi.​org/​10.​1101/​103770
go back to reference Mitchell, S., Brian, J., Zwaigenbaum, L., Roberts, W., Szatmari, P., Smith, I., & Bryson, S. (2006). Early language and communication development of infants later diagnosed with autism spectrum disorder. Journal of Developmental and Behavioral Pediatrics, 27(2 SUPPL. 2). https://doi.org/10.1097/00004703-200604002-00004 Mitchell, S., Brian, J., Zwaigenbaum, L., Roberts, W., Szatmari, P., Smith, I., & Bryson, S. (2006). Early language and communication development of infants later diagnosed with autism spectrum disorder. Journal of Developmental and Behavioral Pediatrics, 27(2 SUPPL. 2). https://​doi.​org/​10.​1097/​00004703-200604002-00004
go back to reference Mullen, E. M. (1995). Mullen scales of early learning. MN: AGS Circle Pines Mullen, E. M. (1995). Mullen scales of early learning. MN: AGS Circle Pines
go back to reference Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L. J., Constantino, J. N., Dobkins, K., Hutman, T., Iverson, J. M., Landa, R., Rogers, S. J., Sigman, M., & Stone, W. L. (2011). Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics, 128(3), e488–e495. https://doi.org/10.1542/PEDS.2010-2825CrossRefPubMedPubMedCentral Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., Bryson, S., Carver, L. J., Constantino, J. N., Dobkins, K., Hutman, T., Iverson, J. M., Landa, R., Rogers, S. J., Sigman, M., & Stone, W. L. (2011). Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics, 128(3), e488–e495. https://​doi.​org/​10.​1542/​PEDS.​2010-2825CrossRefPubMedPubMedCentral
go back to reference Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised. Los Angeles, CA: Western Psychological Services
go back to reference Tager-flusberg, H., & Kasari, C. (2013). Minimally verbal school-aged children with autism spectrum disorder: The neglected end of the spectrum. In Autism Research (Vol. 6, Issue 6, pp. 468–478). NIH Public Access. https://doi.org/10.1002/aur.1329 Tager-flusberg, H., & Kasari, C. (2013). Minimally verbal school-aged children with autism spectrum disorder: The neglected end of the spectrum. In Autism Research (Vol. 6, Issue 6, pp. 468–478). NIH Public Access. https://​doi.​org/​10.​1002/​aur.​1329
go back to reference Viezel, K., Zibulsky, J., Dumont, R., & Willis, J. O. (2014). Bayley scales of infant and toddler development, third edition. In C. R. Reynolds, K. J. Vannest, & E. Fletcher-Janzen (Eds.), Encyclopedia of Special Education: A Reference for the Education of Children, Adolescents, and Adults Disabilities and Other Exceptional Individuals (4th Ed.)., Hoboken, NJ: John Wiley & Sons, Inc Viezel, K., Zibulsky, J., Dumont, R., & Willis, J. O. (2014). Bayley scales of infant and toddler development, third edition. In C. R. Reynolds, K. J. Vannest, & E. Fletcher-Janzen (Eds.), Encyclopedia of Special Education: A Reference for the Education of Children, Adolescents, and Adults Disabilities and Other Exceptional Individuals (4th Ed.)., Hoboken, NJ: John Wiley & Sons, Inc
go back to reference Zimmerman, I. L., Steiner, V. G., & Pond, R. E. (2010). Preschool Language Scale (4th ed., (PLS-4) Hebrew Edition). Israel: Pearson-Psychtech Zimmerman, I. L., Steiner, V. G., & Pond, R. E. (2010). Preschool Language Scale (4th ed., (PLS-4) Hebrew Edition). Israel: Pearson-Psychtech
go back to reference Zimmerman, I. L., Steiner, V. G., & Pond, R. E. (2002). Preschool Language Scale. The Psychological Corporation. San Antonio, TX Zimmerman, I. L., Steiner, V. G., & Pond, R. E. (2002). Preschool Language Scale. The Psychological Corporation. San Antonio, TX
go back to reference Zwaigenbaum, L., Bauman, M. L., Choueiri, R., Kasari, C., Carter, A., Granpeesheh, D., Mailloux, Z., Roley, S. S., Wagner, S., Fein, D., Pierce, K., Buie, T., Davis, P. A., Newschaffer, C., Robins, D., Wetherby, A., Stone, W. L., Yirmiya, N., Estes, A., & Natowicz, M. R. (2015a). Early Intervention for children with autism spectrum disorder under 3 years of age: Recommendations for practice and research. Pediatrics, 136, S60–S81. https://doi.org/10.1542/peds.2014-3667ECrossRefPubMedPubMedCentral Zwaigenbaum, L., Bauman, M. L., Choueiri, R., Kasari, C., Carter, A., Granpeesheh, D., Mailloux, Z., Roley, S. S., Wagner, S., Fein, D., Pierce, K., Buie, T., Davis, P. A., Newschaffer, C., Robins, D., Wetherby, A., Stone, W. L., Yirmiya, N., Estes, A., & Natowicz, M. R. (2015a). Early Intervention for children with autism spectrum disorder under 3 years of age: Recommendations for practice and research. Pediatrics, 136, S60–S81. https://​doi.​org/​10.​1542/​peds.​2014-3667ECrossRefPubMedPubMedCentral
go back to reference Zwaigenbaum, L., Bauman, M. L., Stone, W. L., Yirmiya, N., Estes, A., Hansen, R. L., McPartland, J. C., Natowicz, M. R., Choueiri, R., Fein, D., Kasari, C., Pierce, K., Buie, T., Carter, A., Davis, P. A., Granpeesheh, D., Mailloux, Z., Newschaffer, C., Robins, D., & Wetherby, A. (2015b). Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics, 136, S10–S40. https://doi.org/https://doi.org/10.1542/peds.2014-3667 CCrossRefPubMedPubMedCentral Zwaigenbaum, L., Bauman, M. L., Stone, W. L., Yirmiya, N., Estes, A., Hansen, R. L., McPartland, J. C., Natowicz, M. R., Choueiri, R., Fein, D., Kasari, C., Pierce, K., Buie, T., Carter, A., Davis, P. A., Granpeesheh, D., Mailloux, Z., Newschaffer, C., Robins, D., & Wetherby, A. (2015b). Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics, 136, S10–S40. https://​doi.​org/​https://doi.org/10.1542/peds.2014-3667 CCrossRefPubMedPubMedCentral
Metagegevens
Titel
The Importance of Language Delays as an Early Indicator of Subsequent ASD Diagnosis in Public Healthcare Settings
Auteurs
Tanya Nitzan
Judah Koller
Michal Ilan
Michal Faroy
Analya Michaelovski
Idan Menashe
Gal Meiri
Ilan Dinstein
Publicatiedatum
12-10-2022
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-022-05757-y

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