Top

Journal of Autism and Developmental Disorders

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in:

26-04-2017 | Original Paper

Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability

Auteurs: Emma K. Baker, Amanda L. Richdale, Agnes Hazi, Luke A. Prendergast

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2017

Abstract

This study assessed melatonin levels and the dim light melatonin onset (DLMO) in adults with Autism Spectrum Disorder (ASD) and also investigated the relationships between melatonin and objectively measured sleep parameters. Sixteen adults with ASD (ASD-Only), 12 adults with ASD medicated for comorbid diagnoses of anxiety and/or depression (ASD-Med) and 32 controls participated in the study. Although, the timing of the DLMO did not differ between the two groups, advances and delays of the melatonin rhythm were observed in individual profiles. Overall mean melatonin levels were lower in the ASD-Med group compared to the two other groups. Lastly, greater increases in melatonin in the hour prior to sleep were associated with greater sleep efficiency in the ASD groups.

vorige artikel Acoustic Properties of Cries in 12-Month Old Infants at High-Risk of Autism Spectrum Disorder

volgende artikel Self-Report and Brain Indicators of Impaired Emotion Regulation in the Broad Autism Spectrum

Alleen toegankelijk voor geautoriseerde gebruikers

American Academy of Sleep Medicine (2014). International Classification of Sleep Disorders (3rd edn.). Darien, IL: American Academy of Sleep Medicine.

Antonioli, M., Rybka, J., & Carvalho, L. A. (2012). Neuroimmune endocrine effects of antidepressants. Neuropsychiatric Disease and Treatment, 8, 65–83. doi: 10.2147/NDT.S16409. PubMedPubMedCentral

Arendt, J. (1995). Melatonin and the mammalian pineal gland (1st ed.). London: Chapman & Hall.

Baker, E. K., & Richdale, A. L. (2015). Sleep patterns in adults with a diagnosis of high-functioning autism spectrum disorder. Sleep, 38(11), 1765–1774. doi: 10.5665/sleep.5160. CrossRefPubMedPubMedCentral

Baker, E. K., & Richdale, A. L. (2017). Examining the behavioural sleep–wake rhythm in adults with autism spectrum disorder and no comorbid intellectual disability. Journal of Autism and Developmental Disorders, 47, 1207–1222. doi: 10.1007/s10803-017-3042-3. CrossRefPubMed

Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from asperger syndrome/high-functioning autism, malesand females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. doi: 10.1023/a:1005653411471. CrossRefPubMed

Benloucif, S., Burgess, H. J., Klerman, E. B., Lewy, A. J., Middleton, B., Murphy, P. J., … Revell, V. L. (2008). Measuring melatonin in humans. Journal of Clinical Sleep Medicine, 4, 66–69. PubMedPubMedCentral

Benowitz, N. L. (1990). Clinical pharmacology of caffeine. Annual Review of Medicine, 41, 277–288. doi: 10.1146/annurev.me.41.020190.001425. CrossRefPubMed

Bootzin, R., Shoham, V., & Kuo, T. (1994). Sleep anticipatory anxiety questionnaire: A measure of anxiety about sleep. Sleep Research, 23, 188.

Brzezinski, A. (1997). Melatonin in humans. The New England Journal of Medicine, 336(3), 186–195. doi: 10.1056/NEJM199701163360306. CrossRefPubMed

Burgess, H. J., & Eastman, C. I. (2005). The dim light melatonin onset following fixed and free sleep schedules. Journal of Sleep Research, 14(3), 229–237. doi: 10.1111/j.1365-2869.2005.00470.x. CrossRefPubMed

Burgess, H. J., Wyatt, J. K., Park, M., & Fogg, L. F. (2015). Home circadian phase assessments with measures of compliance yield accurate dim light melatonin onsets. Sleep, 38(6), 889–897. doi: 10.5665/sleep.4734. PubMedPubMedCentral

Carvalho, L. A., Gorenstein, C., Moreno, R., Pariante, C., & Markus, R. P. (2009). Effect of antidepressants on melatonin metabolite in depressed patients. Journal of Psychopharmacology, 23(3), 315–321. doi: 10.1177/0269881108089871. CrossRefPubMed

Cohrs, S., Pohlmann, K., Guan, Z., Jordan, W., Meier, A., Huether, G., Rüther, E., & Rodenbeck, A. (2004). Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects. Psychopharmacology, 174, 414–420, doi: 10.1007/s00213-003-1766-6. PubMed

Cortesi, F., Giannotti, F., Sebastiani, T., Panunzi, S., & Valente, D. (2012). Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. Journal of Sleep Research, 21(6), 700–709, doi: 10.1111/j.1365-2869.2012.01021.x. CrossRefPubMed

Crasson, M., Kjiri, S., Colin, A., Kjiri, K., L’Hermite-Baleriaux, M., Ansseau, M., et al. (2004). Serum melatonin and urinary 6-sulfatoxymelatonin in major depression. Psychoneuroendocrinology, 29(1), 1–12. [doi: 10.1016/S0306-4530(02)00123-3]. CrossRefPubMed

Crowley, S. J. (2013). Assessment of Circadian Rhythms. In A. Wolfson & H. Montgomery-Downs (Eds.), The Oxford Handbook of Infant, Child, and Adolescent Sleep and Behavior. New York, NY: Oxford University Press.

Darcourt, G., Feuillade, P., Bistagnin, Y., Robert, P., Pringuey, D., Touari, M., Mrdji, Y., & Bensmaïl, B. (1995). Antidepressant effect of 5-methoxypsoralen: The melatonin synchronizer hypothesis. European Psychiatry, 10(3), 142–154. doi: 10.1016/0767-399X(96)80103-9. CrossRefPubMed

Dijk, D. J., & Cajochen, C. (1997). Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. Journal of Biological Rhythms, 12(6), 627–635. CrossRefPubMed

Elrod, M. G., & Hood, B. S. (2015). Sleep differences among children with autism spectrum disorders and typically developing peers: A meta-analysis. Journal of Developmental and Behavioral Pediatrics, 36(3), 166–177. CrossRefPubMed

Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009). Circadian misalignment in major depressive disorder. Psychiatry Research, 168(3), 259–261. doi: 10.1016/j.psychres.2009.04.009. CrossRefPubMed

Franklin, M., Clement, E. M., Campling, G., & Cowen, P. J. (1998). Effect of venlafaxine on pineal melatonin and noradrenaline in the male rat. Journal of Psychopharmacology, 12(4), 371–374. CrossRefPubMed

Glickman, G. (2010). Circadian rhythms and sleep in children with autism. Neuroscience and Biobehavioral Reviews, 34(5), 755–768. doi: 10.1016/j.neubiorev.2009.11.017. CrossRefPubMed

Goldman, S. E., Adkins, K. W., Calcutt, M. W., Carter, M. D., Goodpaster, R. L., Wang, L., et al. (2014). Melatonin in children with autism spectrum disorders: endogenous and pharmacokinetic profiles in relation to sleep. Journal of Autism and Developmental Disorders, 44(10), 2525–2535. doi: 10.1007/s10803-014-2123-9. CrossRefPubMedPubMedCentral

Goldman, S. E., Surdyka, K., Cuevas, R., Adkins, K., Wang, L., & Malow, B. (2009). Defining the sleep phenotype in children with autism. Developmental Neuropsychology, 34(5), 560–573. doi: 10.1080/87565640903133509. CrossRefPubMedPubMedCentral

Gotham, K., Brunwasser, S. M., & Lord, C. (2015). Depressive and anxiety symptom trajectories from school age through young adulthood in samples with autism spectrum disorder and developmental delay. Journal of the American Academy of Child & Adolescent Psychiatry, 54(5), 369–376.e363. doi: 10.1016/j.jaac.2015.02.005. CrossRef

Gringras, P., Gamble, C., Jones, A. P., Wiggs, L., Williamson, P. R., Sutcliffe, A., et al. (2012). Melatonin for sleep problems in children with neurodevelopmental disorders: Randomised double masked placebo controlled trial. BMJ (Clinical research ed.), 345, e6664. doi: 10.1136/bmj.e6664. PubMedCentral

Guénolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J.-M. (2011). Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion. Sleep Medicine Reviews, 15(6), 379–387. CrossRefPubMed

Hallam, K. T., Begg, D. P., Olver, J. S., & Norman, T. R. (2008). An investigation of the effect of immediate and extended release venlafaxine on nocturnal melatonin and cortisol release in healthy adult volunteers. Human Psychopharmacology: Clinical and Experimental, 23(2), 129–137. doi: 10.1002/hup.913. CrossRef

Hare, D. J., Jones, S., & Evershed, K. (2006). A comparative study of circadian rhythm functioning and sleep in people with Asperger syndrome. Autism: The International Journal of Research and Practice, 10(6), 565–575. doi: 10.1177/1362361306068509. CrossRef

Hariharasubramanian, N., Nair, N. P., Pilapil, C., Isaac, I., & Quirion, R. (1986). Effect of imipramine on the circadian rhythm of plasma melatonin in unipolar depression. Chronobiology International, 3(1), 65–69. CrossRefPubMed

Härtter, S., Want, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F., & Hiemke, C. (2001). Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. Journal of Clinical Psychopharmacology, 21(2), 167–174. CrossRefPubMed

Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010). Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: Further evidence for circadian misalignment in non-seasonal depression. Psychiatry Research, 178(1), 205–207. doi: 10.1016/j.psychres.2010.04.027. CrossRefPubMedPubMedCentral

Hilli, J., Korhonen, T., Turpeinen, M., Hokkanen, J., Mattila, S., & Laine, K. (2008). The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C > A polymorphism. Journal of Clinical Pharmacology, 48(8), 986–994. doi: 10.1177/0091270008318669. CrossRefPubMed

Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., et al. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. Journal of Autism and Developmental Disorders, 43(6), 1314–1325. doi: 10.1007/s10803-012-1679-5. CrossRefPubMed

Keijzer, H., Smits, M. G., Duffy, J. F., & Curfs, L. M. (2014). Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep Medicine Reviews, 18(4), 333–339. doi: 10.1016/j.smrv.2013.12.001. CrossRefPubMed

Kroenke, K., Strine, T. W., Spitzer, R. L., Williams, J. B. W., Berry, J. T., & Mokdad, A. H. (2009). The PHQ-8 as a measure of current depression in the general population. Journal of Affective Disorders, 114(1–3), 163–173. doi: 10.1016/j.jad.2008.06.026. CrossRefPubMed

Kulman, G., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., & Sequeri, P. (2000). Evidence of pineal endocrine hypofunction in autistic children. Neuro Endocrinology Letters, 21(1), 31–34. PubMed

Li, S., Liu, L., Xu, L., Gao, L., Wang, X., Zhang, J., & Lu, L. (2013). Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment. Psychoneuroendocrinology, 38, 2789–2899, doi: 10.1016/j.psyneuen.2013.07.009. CrossRefPubMed

Leu, R. M., Beyderman, L., Botzolakis, E. J., Surdyka, K., Wang, L., & Malow, B. A. (2011). Relation of melatonin to sleep architecture in children with autism. [Research Support, Non-U.S. Gov’t]. Journal of Autism and Developmental Disorders, 41(4), 427–433, doi: 10.1007/s10803-010-1072-1. CrossRefPubMedPubMedCentral

Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism Diagnostic Observation Schedule (2nd edn.). Los Angeles, CA: Western Psychological Services.

Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., et al. (2012). Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. Journal of Autism and Developmental Disorders, 42(8), 1729–1737. doi: 10.1007/s10803-011-1418-3. CrossRefPubMedPubMedCentral

Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsater, H., et al. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13(1), 90–98. doi: 10.1038/sj.mp.4002016. CrossRefPubMed

Morin, L. P., & Allen, C. N. (2006). The circadian visual system, 2005. Brain Research Reviews, 51(1), 1–60. doi: 10.1016/j.brainresrev.2005.08.003. CrossRefPubMed

Nadeau, J. M., Arnold, E. B., Keene, A. C., Collier, A. B., Lewin, A. B., Murphy, T. K., & Storch, E. A. (2015). Frequency and clinical correlates of sleep-related problems among anxious youth with autism sepctrum disorders. Child Psychiatry and Human Development, 46, 558–566. doi: 10.1007/s10578-014-0496-9. CrossRefPubMed

Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995). Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. Journal of Autism and Developmental Disorders, 25(6), 641–654. CrossRefPubMed

Pagan, C., Delorme, R., Callebert, J., Goubran-Botros, H., Amsellem, F., Drouot, X., et al. (2014). The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational Psychiatry, 4, e479. doi: 10.1038/tp.2014.120. CrossRefPubMedPubMedCentral

Pandi-Perumal, S. R., Smits, M., Spence, W., Srinivasan, V., Cardinali, D. P., Lowe, A. D., et al. (2007a). Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, 31(1), 1–11. doi: 10.1016/j.pnpbp.2006.06.020. CrossRef

Pandi-Perumal, S. R., Srinivasan, V., Maestroni, G. J., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006). Melatonin: Nature’s most versatile biological signal? FEBS J, 273(13), 2813–2838, doi: 10.1111/j.1742-4658.2006.05322.x. CrossRefPubMed

Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., & Cardinali, D. P. (2007b). Role of the melatonin system in the control of sleep: Therapeutic implications. CNS Drugs, 21(12), 995–1018. CrossRefPubMed

Papp, M., Litwa, E., Gruca, P., & Mocaer, E. (2006). Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behavioural Pharmacology, 17(1), 9–18. PubMed

Patzold, L. M., Richdale, A. L., & Tonge, B. J. (1998). An investigation into sleep characteristics of children with autism and Asperger’s disorder. Journal of Paediatrics and Child Health, 34, 528–533. CrossRefPubMed

Richdale, A. L. (1999). Sleep problems in autism: Prevalence, cause, and intervention. Developmental Medicine and Child Neurology, 41, 60–66. CrossRefPubMed

Richdale, A. L., & Schreck, K. A. (2009). Sleep problems in autism spectrum disorders: Prevalence, nature & possible biopsychosocial aetiologies. Sleep Medicine Reviews, 13(6), 403–411. CrossRefPubMed

Ritvo, E., Ritvo, R., Yuwiler, A., Brothers, A., Freeman, B., & Plotkin, S. (1993). Elevated daytime melatonin concentrations in autism: A pilot study. European Child & Adolescent Psychiatry, 2(2), 75–78. doi: 10.1007/bf02098862. CrossRef

Robillard, R., Naismith, S. L., Rogers, N. L., Scott, E. M., Ip, T. K., Hermens, D. F., et al. (2013). Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. European Psychiatry, 28(7), 412–416. doi: 10.1016/j.eurpsy.2013.04.001. CrossRefPubMed

Rubin, R. T., Heist, E., McGeoy, S. S., Hanada, K., & Lesser, I. (1992). Neuroendocrine aspects of primary endogenous depression: Xi. serum melatonin measures in patients and matched control subjects. Archives of General Psychiatry, 49(7), 558–567. doi: 10.1001/archpsyc.1992.01820070052008. CrossRefPubMed

Salti, R., Galluzzi, F., Bindi, G., Perfetto, F., Tarquini, R., Halberg, F., et al. (2000). Nocturnal melatonin patterns in children. Journal of Clinical Endocrinology and Metabolism, 85, 2137–2144. CrossRefPubMed

Spielberger, C. D., Gorsuch, R. L., Lushene, R., Vagg, P. R., & Jacobs, G. A. (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.

Tordjman, S., Anderson, G. M., Bellissant, E., Botbol, M., Charbuy, H., Camus, F., … Touitou, Y. (2012). Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder. Psychoneuroendocrinology, 37, 1990–1997. doi: 10.1016/j.psyneuen.2012.04.013. CrossRefPubMed

Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., & Touitou, Y. (2005). Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry, 57(2), 134–138. doi: 10.1016/j.biopsych.2004.11.003. CrossRefPubMed

Tsaousis, I. (2010). Circadian preferences and personality traits: A meta-analysis. European Journal of Personality, 24(4), 356–373. doi: 10.1002/per.754.

von Bahr, C., Ursing, C., Yasui, N., Tybring, G., Bertilsson, L., & Röjdmark, S. (2000). Fluvoxamine but not citalopram increases serum melatonin in healthy subjects—an indication that cytochrome P 450 CYP1A2 and CYP2C19 hydroxylate melatonin. European Journal of Clinical Pharmacology, 56(2), 123–127. doi: 10.1007/s002280050729. CrossRef

Voultsios, A., Kennaway, D. J., & Dawson, D. (1997). Salivary melatonin as a circadian phase marker: Validation and comparison to plasma melatonin. Journal of Biological Rhythms, 12(5), 457–466. CrossRefPubMed

Wasdell, M. B., Jan, J. E., Bomben, M. M., Freeman, R. D., Rietveld, W. J., Tai, J., et al. (2008). A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. Journal of Pineal Research, 44, 57–64. doi: 10.1111/j.1600-079X.2007.00528.x. PubMed

Wechsler, D. (1999). WASI Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation.

Wechsler, D. (2008). WAIS-IV Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation.

Wiggs, L., & Stores, G. (2004). Sleep patterns and sleep disorders in children with autistic spectrum disorders: Insights using parent report and actigraphy. Developmental Medicine & Child Neurology, 46(6), 372–380. doi: 10.1017/S0012162204000611.

Woodbury-Smith, M. R., Robinson, J., Wheelwright, S., & Baron-Cohen, S. (2005). Screening adults for Asperger Syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. Journal of Autism and Developmental Disorders, 35(3), 331–335. CrossRefPubMed

Zawilska, J. B., Skene, D. J., & Arendt, J. (2009). Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacological Reports, 61(3), 383–410. CrossRefPubMed

Titel: Assessing the Dim Light Melatonin Onset in Adults with Autism Spectrum Disorder and No Comorbid Intellectual Disability
Auteurs: Emma K. Baker
Amanda L. Richdale
Agnes Hazi
Luke A. Prendergast
Publicatiedatum: 26-04-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3122-4

Bohn Stafleu van Loghum

Tip

Swipe om te navigeren naar een ander artikel

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 7/2017

Family Quality of Life of South African Families Raising Children with Autism Spectrum Disorder

Social Motor Synchronization: Insights for Understanding Social Behavior in Autism

Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD

Measuring Theory of Mind in Adults with Autism Spectrum Disorder

Can Children with Autism Spectrum Disorders Learn New Vocabulary From Linguistic Context?

The Prevalence of Internet Addiction Among a Japanese Adolescent Psychiatric Clinic Sample With Autism Spectrum Disorder and/or Attention-Deficit Hyperactivity Disorder: A Cross-Sectional Study