Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-04-2011 | Original Paper

Relation of Melatonin to Sleep Architecture in Children with Autism

Auteurs: Roberta M. Leu, Liya Beyderman, Emmanuel J. Botzolakis, Kyla Surdyka, Lily Wang, Beth A. Malow

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2011

Abstract

Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness.

vorige artikel The Hypothesis of Apraxia of Speech in Children with Autism Spectrum Disorder

volgende artikel Detecting Social and Non-Social Changes in Natural Scenes: Performance of Children with and Without Autism Spectrum Disorders and Typical Adults

Allik, H., Larsson, J. O., & Smedje, H. (2006). Insomnia in school-age children with Asperger syndrome or high-functioning autism. BMC Psychiatry, 6, 18.PubMedCrossRef

American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, 4th edition. text revision. Washington, DC: American Psychiatric Association.CrossRef

Andersen, I. M., Kaczmarska, J., McGrew, S. G., & Malow, B. A. (2008). Melatonin for insomnia in children with autism spectrum disorders. Journal of Child Neurology, 23(5), 482–485.PubMedCrossRef

Autism and Developmental Disabilities Monitoring Network, United States, 2006. (2009). Prevalence of autism spectrum disorders. MMWR Surveillance Summaries, 58(1), 57–66.

Beck-Friis, J., von Rosen, D., Kjellman, B. F., Ljunggren, J. G., & Wetterberg, L. (1984). Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology, 9(3), 61–277.CrossRef

Bojkowski, C. J., & Arendt, J. (1988). Annual changes in 6-sulphatoxymelatonin excretion in man. Acta Endocrinologica, 117(4), 470–476.PubMed

Brzezinski, A., Vangel, M. G., Wurtman, R. J., Norrie, G., Zhdanova, I., Ben-Shushan, A., et al. (2005). Effects of exogenous melatonin on sleep: A meta-analysis. Sleep Medicine Reviews, 9(1), 41–50.PubMedCrossRef

Cagnacci, A. (1996). Melatonin in relation to physiology in adult humans. Journal of Pineal Research, 21(4), 200–213.PubMedCrossRef

Cardinali, D. P., & Pevet, P. (1998). Basic aspects of melatonin action. Sleep Medicine Reviews, 2(3), 175–190.PubMedCrossRef

Chamberlain, R. S., & Herman, B. H. (1990). A novel biochemical model linking dysfunctions in brain melatonin, proopiomelanocortin peptides, and serotonin in autism. Biological Psychiatry, 28(9), 773–793.PubMedCrossRef

Champier, J., Claustrat, B., Besancon, R., Eymin, C., Killer, C., Jouvet, A., et al. (1997). Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets. Life Sciences, 60(24), 2191–2197.PubMedCrossRef

Conti, A., Conconi, S., Hertens, E., Skwarlo-Sonta, K., Markowska, M., & Maestroni, J. M. (2000). Evidence for melatonin synthesis in mouse and human bone marrow cells. Journal of Pineal Research, 28(4), 193–202.PubMedCrossRef

Couturier, J. L., Speechley, K. N., Steele, M., Norman, R., Stringer, B., & Nicolson, R. (2005). Parental perception of sleep problems in children of normal intelligence with pervasive developmental disorders: Prevalence, severity, and pattern. Journal of the American Academy of Child and Adolescent Psychiatry, 44(8), 815–822.PubMedCrossRef

Garstang, J., & Wallis, M. (2006). Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems. Child: Care, Health and Development, 32(5), 585–589.CrossRef

Giannotti, F., Cortesi, F., Cerquiglini, A., & Bernabei, P. (2006). An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism. Journal of Autism and Developmental Disorders, 36(6), 741–752.PubMedCrossRef

Goldman, S. E., Surdyka, K., Cuevas, R., Adkins, K., Wang, L., & Malow, B. A. (2009). Defining the sleep phenotype in children with autism. Developmental Neuropsychology, 34(5), 560–573.PubMedCrossRef

Goodlin-Jones, B. L., Sitnick, S. L., Tang, K., Liu, J., & Anders, T. F. (2008a). The children’s sleep habits questionnaire in toddlers and preschool children. Journal of Developmental and Behavioral Pediatrics, 29(2), 82–88.PubMedCrossRef

Goodlin-Jones, B. L., Tang, K., Liu, J., & Anders, T. F. (2008b). Sleep patterns in preschool-age children with autism, developmental delay, and typical development. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 930–938.PubMed

Graham, C., Cook, M. R., Kavet, R., Sastre, A., & Smith, D. K. (1998). Prediction of nocturnal plasma melatonin from morning urinary measures. Journal of Pineal Research, 24(4), 230–238.PubMedCrossRef

Honomichl, R. D., Goodlin-Jones, B. L., Burnham, M., Gaylor, E., & Anders, T. F. (2002). Sleep patterns of children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 32(6), 553–561.PubMedCrossRef

Iber, C., Ancoli-Israel, S., Chesson, A. L., Quan, S. F., & for the American Academy of Sleep Medicine. (2007). The AASM manual for scoring of sleep and associated events: Rules, terminology and technical specification (1st ed.). Westchester, IL: American Academy of Sleep Medicine.

Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., & Laudon, M. (2000). Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders. Journal of Pineal Research, 29(1), 34–39.PubMedCrossRef

Kauppila, A., Kivela, A., Pakarinen, A., & Vakkuri, O. (1987). Inverse seasonal relationship between melatonin and ovarian activity in humans in a region with a strong seasonal contrast in luminosity. The Journal of Clinical Endocrinology and Metabolism, 65(5), 823–828.PubMedCrossRef

Kulman, G., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., & Sequeri, P. (2000). Evidence of pineal endocrine hypofunction in autistic children. Neuroendocrinology Letters, 21(1), 31–34.PubMed

Luboshitzky, R., Yanai, D., Shen-Orr, Z., Israeli, E., Herer, P., & Lavie, P. (1998). Daily and seasonal variations in the concentration of melatonin in the human pineal gland. Brain Research Bulletin, 47(3), 271–276.PubMedCrossRef

Malow, B. A. (2004). Sleep disorders, epilepsy, and autism. Mental Retardation and Developmental Disabilities Research Reviews, 10(2), 122–125.PubMedCrossRef

Malow, B. A., Marzec, M. L., McGrew, S. G., Wang, L., Henderson, L. M., & Stone, W. L. (2006). Characterizing sleep in children with autism spectrum disorders: A multidimensional approach. Sleep, 29(12), 1563–1571.PubMed

McGrew, S., Malow, B. A., Henderson, L., Wang, L., Song, Y., & Stone, W. L. (2007). Developmental and behavioral questionnaire for autism spectrum disorders. Pediatric Neurology, 37(2), 108–116.PubMedCrossRef

Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsater, H., et al. (2008). Abnormal melatonin synthesis in autism spectrum disorders. Molecular Psychiatry, 13(1), 90–98.PubMedCrossRef

Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995). Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. Journal of Autism and Developmental Disorders, 25(6), 641–654.PubMedCrossRef

Nowak, R., McMillen, I. C., Redman, J., & Short, R. V. (1987). The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: Two non-invasive techniques for monitoring human circadian rhythmicity. Clinical Endocrinology (Oxford), 27(4), 445–452.CrossRef

Owens, J. A., Spirito, A., & McGuinn, M. (2000). The children’s sleep habits questionnaire (CSHQ): Psychometric properties of a survey instrument for school-aged children. Sleep, 23(8), 1043–1051.PubMed

Paavonen, E. J., Nieminen-von Wendt, T., Vanhala, R., Aronen, E. T., & von Wendt, L. (2003). Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder. Journal of Child and Adolescent Psychopharmacology, 13(1), 83–95.PubMedCrossRef

Richdale, A. L. (1999). Sleep problems in autism: Prevalence, cause, and intervention. Developmental Medicine and Child Neurology, 41(1), 60–66.PubMedCrossRef

Ronnberg, L., Kauppila, A., Leppaluoto, J., Martikainen, H., & Vakkuri, O. (1990). Circadian and seasonal variation in human preovulatory follicular fluid melatonin concentration. The Journal of Clinical Endocrinology and Metabolism, 71(2), 492–496.PubMedCrossRef

Schreck, K. A., Mulick, J. A., & Smith, A. F. (2004). Sleep problems as possible predictors of intensified symptoms of autism. Research in Developmental Disabilities, 25(1), 57–66.PubMedCrossRef

Sivan, Y., Laudon, M., Tauman, R., & Zisapel, N. (2001). Melatonin production in healthy infants: Evidence for seasonal variations. Pediatric Research, 49(1), 63–68.PubMedCrossRef

Slominski, A., Tobin, D. J., Zmijewski, M. A., Wortsman, J., & Paus, R. (2008). Melatonin in the skin: Synthesis, metabolism and functions. Trends in Endocrinology and Metabolism, 19(1), 17–24.PubMedCrossRef

Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., & Touitou, Y. (2005). Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry, 57(2), 134–138.PubMedCrossRef

Wiggs, L., & Stores, G. (2004). Sleep patterns and sleep disorders in children with autistic spectrum disorders: Insights using parent report and actigraphy. Developmental Medicine and Child Neurology, 46(6), 372–380.PubMedCrossRef

Williams, P. G., Sears, L. L., & Allard, A. (2004). Sleep problems in children with autism. Journal of Sleep Research, 13, 265–268.CrossRef

Wirojanan, J., Jacquemont, S., Diaz, R., Bacalman, S., Anders, T. F., Hagerman, R. J., et al. (2009). The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. Journal of Clinical Sleep Medicine, 5(2), 145–150.PubMed

Titel: Relation of Melatonin to Sleep Architecture in Children with Autism
Auteurs: Roberta M. Leu
Liya Beyderman
Emmanuel J. Botzolakis
Kyla Surdyka
Lily Wang
Beth A. Malow
Publicatiedatum: 01-04-2011
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-010-1072-1

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 4/2011

Brief Report: Memory Performance on the California Verbal Learning Test - Children’s Version in Autism Spectrum Disorder

Brief Report: Preliminary Evaluation of the Theory of Mind Inventory and its Relationship to Measures of Social Skills

Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument

Brief Report: Theatre as Therapy for Children with Autism Spectrum Disorder

Kathy J. Marshack: Life with a Partner or Spouse with Asperger Syndrome: Going Over the Edge? Practical Steps to Saving You and Your Relationship

Imitation Assessment and Its Utility to the Diagnosis of Autism: Evidence from Consecutive Clinical Preschool Referrals for Suspected Autism