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Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2015

16-05-2015 | Letter to the Editor

Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder

Auteurs: Gerrit I. Van Schalkwyk, Alan S. Lewis, Zheala Qayyum, Kourtney Koslosky, Marina R. Picciotto, Fred R. Volkmar

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2015

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Abstract

Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted.
Literatuur
go back to reference Adler, B. A., Wink, L. K., Early, M., Shaffer, R., Minshawi, N., McDougle, C. J., & Erickson, C. A. (2014). Drug-refractory aggression, self-injurious behavior, and severe tantrums in autism spectrum disorders: A chart review study. Autism: The International Journal of Research and Practice,. doi: 10.​1177/​1362361314524641​. Adler, B. A., Wink, L. K., Early, M., Shaffer, R., Minshawi, N., McDougle, C. J., & Erickson, C. A. (2014). Drug-refractory aggression, self-injurious behavior, and severe tantrums in autism spectrum disorders: A chart review study. Autism: The International Journal of Research and Practice,. doi: 10.​1177/​1362361314524641​.
go back to reference Allen, M. H., Debanné, M., Lazignac, C., Adam, E., Dickinson, L. M., & Damsa, C. (2011). Effect of nicotine replacement therapy on agitation in smokers with schizophrenia: A double-blind, randomized, placebo-controlled study. The American Journal of Psychiatry, 168(4), 395–399. doi: 10.​1176/​appi.​ajp.​2010.​10040569. CrossRefPubMed Allen, M. H., Debanné, M., Lazignac, C., Adam, E., Dickinson, L. M., & Damsa, C. (2011). Effect of nicotine replacement therapy on agitation in smokers with schizophrenia: A double-blind, randomized, placebo-controlled study. The American Journal of Psychiatry, 168(4), 395–399. doi: 10.​1176/​appi.​ajp.​2010.​10040569. CrossRefPubMed
go back to reference Arnold, L. E., Anand, R., & Aman, M. (2013). Varencline in autistic disorder: Hypothesis and case report of single-patient crossover. Journal of Child and Adolescent Psychopharmacology,. doi: 10.​1089/​cap.​2012.​0025. Arnold, L. E., Anand, R., & Aman, M. (2013). Varencline in autistic disorder: Hypothesis and case report of single-patient crossover. Journal of Child and Adolescent Psychopharmacology,. doi: 10.​1089/​cap.​2012.​0025.
go back to reference Berntson, G. G., Beattie, M. S., & Walker, J. M. (1976). Effects of nicotinic and muscarinic compounds on biting attack in the cat. Pharmacology, Biochemistry and Behavior, 5(3), 235–239. CrossRefPubMed Berntson, G. G., Beattie, M. S., & Walker, J. M. (1976). Effects of nicotinic and muscarinic compounds on biting attack in the cat. Pharmacology, Biochemistry and Behavior, 5(3), 235–239. CrossRefPubMed
go back to reference Buckley, A. W., Sassower, K., Rodriguez, A. J., Jennison, K., Wingert, K., Buckley, J., et al. (2011). An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 21, 353–357. doi: 10.​1089/​cap.​2010.​0121. PubMedCentralCrossRefPubMed Buckley, A. W., Sassower, K., Rodriguez, A. J., Jennison, K., Wingert, K., Buckley, J., et al. (2011). An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 21, 353–357. doi: 10.​1089/​cap.​2010.​0121. PubMedCentralCrossRefPubMed
go back to reference Driscoll, P., & Baettig, K. (1981). Selective inhibition by nicotine of shock-induced fighting in the rat. Pharmacology, Biochemistry and Behavior, 14(2), 175–179. CrossRefPubMed Driscoll, P., & Baettig, K. (1981). Selective inhibition by nicotine of shock-induced fighting in the rat. Pharmacology, Biochemistry and Behavior, 14(2), 175–179. CrossRefPubMed
go back to reference Hellings, J. A., Zarcone, J. R., Crandall, K., Wallace, D., & Schroeder, S. R. (2001). Weight gain in a controlled study of risperidone in children, adolescents and adults with mental retardation and autism. Journal of Child and Adolescent Psychopharmacology, 11(3), 229–238. doi: 10.​1089/​1044546015259555​9. CrossRefPubMed Hellings, J. A., Zarcone, J. R., Crandall, K., Wallace, D., & Schroeder, S. R. (2001). Weight gain in a controlled study of risperidone in children, adolescents and adults with mental retardation and autism. Journal of Child and Adolescent Psychopharmacology, 11(3), 229–238. doi: 10.​1089/​1044546015259555​9. CrossRefPubMed
go back to reference Hughes, J. R., Pillitteri, J. L., Callas, P. W., Callahan, R., & Kenny, M. (2004). Misuse of and dependence on over-the-counter nicotine gum in a volunteer sample. Nicotine and Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco, 6, 79–84. doi: 10.​1080/​1462220031000165​6894. CrossRef Hughes, J. R., Pillitteri, J. L., Callas, P. W., Callahan, R., & Kenny, M. (2004). Misuse of and dependence on over-the-counter nicotine gum in a volunteer sample. Nicotine and Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco, 6, 79–84. doi: 10.​1080/​1462220031000165​6894. CrossRef
go back to reference Johnson, S. K., Carlson, K. M., Lee, J., Burr, L. E., & Wagner, G. C. (2003). Effects of nicotine on target biting and resident-intruder attack. Life Sciences, 73(3), 311–317. CrossRefPubMed Johnson, S. K., Carlson, K. M., Lee, J., Burr, L. E., & Wagner, G. C. (2003). Effects of nicotine on target biting and resident-intruder attack. Life Sciences, 73(3), 311–317. CrossRefPubMed
go back to reference Joseph, A. M., Norman, S. M., Ferry, L. H., Prochazka, A. V., Westman, E. C., Steele, B. G., et al. (1996). The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. The New England Journal of Medicine, 335, 1792–1798. doi: 10.​1056/​NEJM199612123352​402. CrossRefPubMed Joseph, A. M., Norman, S. M., Ferry, L. H., Prochazka, A. V., Westman, E. C., Steele, B. G., et al. (1996). The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. The New England Journal of Medicine, 335, 1792–1798. doi: 10.​1056/​NEJM199612123352​402. CrossRefPubMed
go back to reference Lee, M., Martin-Ruiz, C., Graham, A., Court, J., Jaros, E., Perry, R., et al. (2002). Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain: A Journal of Neurology, 125(Pt 7), 1483–1495. CrossRef Lee, M., Martin-Ruiz, C., Graham, A., Court, J., Jaros, E., Perry, R., et al. (2002). Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain: A Journal of Neurology, 125(Pt 7), 1483–1495. CrossRef
go back to reference McDougle, C. J., Stigler, K. A., & Posey, D. J. (2003). Treatment of aggression in children and adolescents with autism and conduct disorder. Journal of Clinical Psychiatry, 64, 16–25. PubMed McDougle, C. J., Stigler, K. A., & Posey, D. J. (2003). Treatment of aggression in children and adolescents with autism and conduct disorder. Journal of Clinical Psychiatry, 64, 16–25. PubMed
go back to reference Mikhail, F. M., Lose, E. J., Robin, N. H., Descartes, M. D., Rutledge, K. D., Rutledge, S. L., et al. (2011). Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders. American Journal of Medical Genetics, Part A, 155, 2386–2396. doi: 10.​1002/​ajmg.​a.​34177. CrossRef Mikhail, F. M., Lose, E. J., Robin, N. H., Descartes, M. D., Rutledge, K. D., Rutledge, S. L., et al. (2011). Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders. American Journal of Medical Genetics, Part A, 155, 2386–2396. doi: 10.​1002/​ajmg.​a.​34177. CrossRef
go back to reference Perry, E. K., Lee, M. L., Martin-Ruiz, C. M., Court, J. A., Volsen, S. G., Merrit, J., et al. (2001). Cholinergic activity in autism: Abnormalities in the cerebral cortex and basal forebrain. The American Journal of Psychiatry, 158(7), 1058–1066. CrossRefPubMed Perry, E. K., Lee, M. L., Martin-Ruiz, C. M., Court, J. A., Volsen, S. G., Merrit, J., et al. (2001). Cholinergic activity in autism: Abnormalities in the cerebral cortex and basal forebrain. The American Journal of Psychiatry, 158(7), 1058–1066. CrossRefPubMed
go back to reference Rodgers, R. J. (1979). Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats. Psychopharmacology (Berl), 66(1), 93–98. CrossRef Rodgers, R. J. (1979). Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats. Psychopharmacology (Berl), 66(1), 93–98. CrossRef
go back to reference Srivastava, E. D., Russell, M. A., Feyerabend, C., Masterson, J. G., & Rhodes, J. (1991). Sensitivity and tolerance to nicotine in smokers and nonsmokers. Psychopharmacology (Berl), 105, 63–68. doi: 10.​1007/​BF02316865. CrossRef Srivastava, E. D., Russell, M. A., Feyerabend, C., Masterson, J. G., & Rhodes, J. (1991). Sensitivity and tolerance to nicotine in smokers and nonsmokers. Psychopharmacology (Berl), 105, 63–68. doi: 10.​1007/​BF02316865. CrossRef
go back to reference Snaedal, J., Johannesson, T., Jonsson, J. E., & Gylfadottir, G. (1996). The effects of nicotine in dermal plaster on cognitive functions in patients with Alzheimer’s disease. Dementia (Basel, Switzerland) 7: 47–52. Snaedal, J., Johannesson, T., Jonsson, J. E., & Gylfadottir, G. (1996). The effects of nicotine in dermal plaster on cognitive functions in patients with Alzheimer’s disease. Dementia (Basel, Switzerland) 7: 47–52.
go back to reference Waldbillig, R. J. (1980). Suppressive effects of intraperitoneal and intraventricular injections of nicotine on muricide and shock-induced attack on conspecifics. Pharmacology, Biochemistry and Behavior, 12(4), 619–623. CrossRefPubMed Waldbillig, R. J. (1980). Suppressive effects of intraperitoneal and intraventricular injections of nicotine on muricide and shock-induced attack on conspecifics. Pharmacology, Biochemistry and Behavior, 12(4), 619–623. CrossRefPubMed
go back to reference West, R., Hajek, P., Foulds, J., Nilsson, F., May, S., & Meadows, A. (2000). A comparison of the abuse liability and dependence potential of nicotine patch, gum, spray and inhaler. Psychopharmacology (Berl), 149, 198–202. doi: 10.​1007/​s002130000382. CrossRef West, R., Hajek, P., Foulds, J., Nilsson, F., May, S., & Meadows, A. (2000). A comparison of the abuse liability and dependence potential of nicotine patch, gum, spray and inhaler. Psychopharmacology (Berl), 149, 198–202. doi: 10.​1007/​s002130000382. CrossRef
go back to reference White, H. K., & Levin, E. D. (1999). Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer’s disease. Psychopharmacology (Berl), 143, 158–165. doi: 10.​1007/​s002130050931. CrossRef White, H. K., & Levin, E. D. (1999). Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer’s disease. Psychopharmacology (Berl), 143, 158–165. doi: 10.​1007/​s002130050931. CrossRef
go back to reference White, H. K., & Levin, E. D. (2004). Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. Psychopharmacology (Berl), 171, 465–471. doi: 10.​1007/​s00213-003-1614-8. CrossRef White, H. K., & Levin, E. D. (2004). Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. Psychopharmacology (Berl), 171, 465–471. doi: 10.​1007/​s00213-003-1614-8. CrossRef
go back to reference Yasui, D. H., Scoles, H. A., Horike, S.-I., Meguro-Horike, M., Dunaway, K. W., Schroeder, D. I., & Lasalle, J. M. (2011). 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Human Molecular Genetics, 20(22), 4311–4323. doi: 10.​1093/​hmg/​ddr357. PubMedCentralCrossRefPubMed Yasui, D. H., Scoles, H. A., Horike, S.-I., Meguro-Horike, M., Dunaway, K. W., Schroeder, D. I., & Lasalle, J. M. (2011). 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Human Molecular Genetics, 20(22), 4311–4323. doi: 10.​1093/​hmg/​ddr357. PubMedCentralCrossRefPubMed
Metagegevens
Titel
Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder
Auteurs
Gerrit I. Van Schalkwyk
Alan S. Lewis
Zheala Qayyum
Kourtney Koslosky
Marina R. Picciotto
Fred R. Volkmar
Publicatiedatum
16-05-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-015-2471-0

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