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23-05-2015 | Original Paper

Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism

Auteurs: Brittany G. Travers, Erin D. Bigler, Do P. M. Tromp, Nagesh Adluru, Dan Destiche, Danica Samsin, Alyson Froehlich, Molly D. B. Prigge, Tyler C. Duffield, Nicholas Lange, Andrew L. Alexander, Janet E. Lainhart

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2015

Abstract

Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD.

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Titel: Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism
Auteurs: Brittany G. Travers
Erin D. Bigler
Do P. M. Tromp
Nagesh Adluru
Dan Destiche
Danica Samsin
Alyson Froehlich
Molly D. B. Prigge
Tyler C. Duffield
Nicholas Lange
Andrew L. Alexander
Janet E. Lainhart
Publicatiedatum: 23-05-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2467-9

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