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Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2018

11-10-2017 | Original Paper

Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder

Auteurs: Luc Lecavalier, Xueliang Pan, Tristram Smith, Benjamin L. Handen, L. Eugene Arnold, Laura Silverman, Rameshwari V. Tumuluru, Jill Hollway, Michael G. Aman

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2018

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Abstract

We previously reported a 2 × 2 randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention deficit hyperactivity disorder (ADHD) symptoms and behavioral noncompliance in 128 children with autism spectrum disorder, ages 5–14 years. Children were randomized to one of four conditions: ATX alone, placebo alone, ATX + PT, or PT + placebo. Both ATX and PT improved some indices of ADHD and behavioral compliance. In this report, we describe parent stress over time and across conditions. All four treatments improved parent self-rated stress from baseline to week 10. However, there were no statistically significant differences between treatment groups. Significantly more improvement in parent stress scores was observed for clinical responders than non-responders.
ClinicalTrials.gov Title: Atomoxetine, Placebo and Parent Management Training in Autism (Strattera) ClinicalTrials.gov Identifier: NCT00844753.
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Metagegevens
Titel
Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder
Auteurs
Luc Lecavalier
Xueliang Pan
Tristram Smith
Benjamin L. Handen
L. Eugene Arnold
Laura Silverman
Rameshwari V. Tumuluru
Jill Hollway
Michael G. Aman
Publicatiedatum
11-10-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3345-4

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