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Journal of Autism and Developmental Disorders

Gepubliceerd in:

30-09-2016 | Original Paper

Mapping the Network of Neuropsychological Impairment in Children with Autism Spectrum Disorder: A Graph Theoretical Analysis

Auteurs: George M. Ibrahim, Benjamin R. Morgan, Vanessa M. Vogan, Rachel C. Leung, Evdokia Anagnostou, Margot J. Taylor

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2016

Abstract

Children with autism spectrum disorder (ASD) exhibit social-communicative impairments. Less is known about the neuropsychological profile of ASD, although cognitive and neuropsychological deficits are evident. We modelled neuropsychological function in 20 children with ASD and 20 sex, age and IQ matched typically-developing controls (ages 7–14) as a network of interacting parameters. Graph theoretical analysis was applied to identify critical topographic regions within this network. Two areas were significantly stronger hubs in typically-developing children, the ability to shift attention (p < 0.001) and overall executive function (p < 0.001). Planning/organization was a stronger hub in the cognitive networks of children with ASD (p = 0.001). We show that ASD is not only characterized by impairments in various neurocognitive domains, but also alterations in their interaction.

vorige artikel Lexical Processing in Toddlers with ASD: Does Weak Central Coherence Play a Role?

volgende artikel Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders

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Titel: Mapping the Network of Neuropsychological Impairment in Children with Autism Spectrum Disorder: A Graph Theoretical Analysis
Auteurs: George M. Ibrahim
Benjamin R. Morgan
Vanessa M. Vogan
Rachel C. Leung
Evdokia Anagnostou
Margot J. Taylor
Publicatiedatum: 30-09-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2929-8

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