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Journal of Autism and Developmental Disorders

Gepubliceerd in:

23-05-2017 | Brief Report

Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs

Auteurs: Johan Isaksson, Erik Pettersson, Elzbieta Kostrzewa, Rochellys Diaz Heijtz, Sven Bölte

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2017

Abstract

Autism spectrum disorder (ASD) has been associated with gastrointestinal (GI) problems, but the nature of this association is unclear. Parents to siblings, concordant or discordant for ASD (N = 217), participated in a web survey covering mother’s weight gain during pregnancy, maternal viral/bacterial infection and use of antibiotics, duration of breastfeeding, mode of delivery, birth weight and child GI problems. ASD was associated with GI problems and perinatal environmental risk, based on a summation of maternal infection and antibiotic use during pregnancy and/or the breastfeeding period. The association between GI problems and ASD remained within the sibling pairs (β = 1.23; p < .001) in the adjusted model. Our results indicate non-shared environmental effects on the ASD/GI association, but none of the factors examined explained the link.

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Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011). Gastrointestinal flora and gastrointestinal status in children with autism—comparisons to typical children and correlation with autism severity. BMC Gastroenterology, 11, 22.CrossRefPubMedPubMedCentral

Adams, J. B., Romdalvik, J., Ramanujam, V. M., & Legator, M. S. (2007). Mercury, lead, and zinc in baby teeth of children with autism versus controls. Journal of Toxicology and Environmental Health A, 70(12), 1046–1051.CrossRef

Adlerberth, I., & Wold, A. E. (2009). Establishment of the gut microbiota in Western infants. Acta Paediatrica, 98(2), 229–238.CrossRefPubMed

Allison, P. (2009). Fixed effects regression models. Los Angeles: Sage Publications.CrossRef

Arentsen, T., Qian, Y., Gkotzis, S., Femenia, T., Wang, T., Udekwu, K., Forssberg, H., & Diaz Heijtz, R. (2017). The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Molecular Psychiatry, 22, 257–266.CrossRefPubMed

Arentsen, T., Raith, H., Qian, Y., Forssberg, H., & Diaz Heijtz, R. (2015). Host microbiota modulates development of social preference in mice. Microbial Ecology in Health and Disease, 15(26), 29719.

Bölte, E. R. (1998). Autism and Clostridium tetani. Medical Hypotheses, 51(2), 133–144.CrossRefPubMed

Campbell, D. B., Buie, T. M., Winter, H., Bauman, M., Sutcliffe, J. S., Perrin, J. M., & Levitt, P. (2009). Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics, 123(3), 1018–1024.CrossRefPubMed

Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014). Gastrointestinal problems in children with autism, developmental delays or typical development. Journal of Autism and Developmental Disorders, 44(5), 1117–1127.CrossRefPubMedPubMedCentral

Curran, E. A., Dalman, C., Kearney, P. M., Kenny, L. C., Cryan, J. F., Dinan, T. G., & Khashan, A. S. (2015b). Association between obstetric mode of delivery and autism spectrum disorder: A population-based sibling design study. JAMA Psychiatry, 72(9), 935–942.CrossRefPubMed

Curran, E. A., O’Neill, S. M., Cryan, J. F., Kenny, L. C., Dinan, T. G., Khashan, A. S., & Kearney, P. M. (2015a). Research review: Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Journal of Child Psychology and Psychiatry, 56(5), 500–508.CrossRefPubMed

Diaz Heijtz, R. (2016). Fetal, neonatal, and infant microbiome: Perturbations and subsequent effects on brain development and behavior. Seminars in Fetal Neonatal Medicine, 21(6), 410–417.CrossRefPubMed

Diaz Heijtz, R., Wang, S., Anuar, F., Qian, Y., Bjorkholm, B., Samuelsson, A., & Pettersson, S. (2011). Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences of the United States of America, 108(7), 3047–3052.CrossRefPubMed

Dimenas, E., Glise, H., Hallerback, B., Hernqvist, H., Svedlund, J., & Wiklund, I. (1995). Well-being and gastrointestinal symptoms among patients referred to endoscopy owing to suspected duodenal ulcer. Scandinavian Journal of Gastroenterology, 30(11), 1046–1052.CrossRefPubMed

Dinan, T. G., & Cryan, J. F. (2016). Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 42(1), 178–192.CrossRef

Gardener, H., Spiegelman, D., & Buka, S. L. (2011). Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics, 128(2), 344–355.CrossRefPubMedPubMedCentral

Husk, J. S., & Keim, S. A. (2015). Breastfeeding and autism spectrum disorder in the National Survey of Children’s Health. Epidemiology, 26(4), 451–457.CrossRefPubMed

Jašarević, E., Rodgers, A. B., & Bale, T. L. (2015). A novel role for maternal stress and microbial transmission in early life programming and neurodevelopment. Neurobiology of Stress, 1, 81–88.CrossRefPubMed

Jimenez, E., Marin, M. L., Martin, R., Odriozola, J. M., Olivares, M., Xaus, J., & Rodriguez, J. M. (2008). Is meconium from healthy newborns actually sterile? Research in Microbiology, 159(3), 187–193.CrossRefPubMed

Kang, D. W., Adams, J. B., Gregory, A. C., Borody, T., Chittick, L., Fasano, A., & Krajmalnik-Brown, R. (2017). Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome, 5, 10.CrossRefPubMedPubMedCentral

Konstantareas, M. M., & Homatidis, S. (1987). Ear infections in autistic and normal children. Journal of Autism and Developmental Disorders, 17(4), 585–594.CrossRefPubMed

Krajmalnik-Brown, R., Lozupone, C., Kang, D. W., & Adams, J. B. (2015). Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease. Microbial Ecology in Health and Disease, 26, 26914. doi:10.3402/mehd.v26.26914.PubMed

Lahey, B. B., & D’Onofrio, B. M. (2010). All in the family: Comparing siblings to test causal hypotheses regarding environmental influences on behavior. Current Direction in Psychological Science, 19(5), 319–323.CrossRef

Li, Q., & Zhou, J. M. (2016). The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience, 324, 131–139.CrossRefPubMed

Marques, T. M., Wall, R., Ross, R. P., Fitzgerald, G. F., Ryan, C. A., & Stanton, C. (2010). Programming infant gut microbiota: influence of dietary and environmental factors. Current Opinion in Biotechnology, 21(2), 149–156.CrossRefPubMed

Niehus, R., & Lord, C. (2006). Early medical history of children with autism spectrum disorders. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S120–S127.CrossRefPubMed

Plomin, R., & Daniels, D. (2011). Why are children in the same family so different from one another? International Journal of Epidemiology, 40(3), 563–582.CrossRefPubMedPubMedCentral

Quigley, M. A., Hockley, C., Carson, C., Kelly, Y., Renfrew, M. J., & Sacker, A. (2012). Breastfeeding is associated with improved child cognitive development: A population-based cohort study. The Journal of Pediatrics, 160(1), 25–32.CrossRefPubMed

R Core Team (2015). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. http://www.R-project.org/.

Rome foundation. Citing source: http://theromefoundation.org.

Risch, N., Hoffmann, T. J., Anderson, M., Croen, L. A., Grether, J. K., & Windham, G. C. (2014). Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions. The American Journal of Psychiatry, 171(11), 1206–1213.CrossRefPubMed

Schultz, S. T., Klonoff-Cohen, H. S., Wingard, D. L., Akshoomoff, N. A., Macera, C. A., Ji, M., & Bacher, C. (2006). Breastfeeding, infant formula supplementation, and autistic disorder: The results of a parent survey. International Breastfeeding Journal, 1, 16. doi:10.1186/1746-4358-1-16.CrossRefPubMedPubMedCentral

Shin, H., Pei, Z., Martinez, K. A. II, Rivera-Vinas, J. I., Mendez, K., Cavallin, H., & Dominguez-Bello, M. G. (2015). The first microbial environment of infants born by C-section: The operating room microbes. Microbiome, 3, 59. doi:10.1186/s40168-015-0126-1.CrossRefPubMedPubMedCentral

Tick, B., Bolton, P., Happé, F., Rutter, M., & Rijsdijk, F. (2016). Heritability of autism spectrum disorders: A meta-analysis of twin studies. Journal of Child Psychology and Psychiatry, 57(5), 585–595.CrossRefPubMed

Vuong, H. E., & Hsiao, E. Y. (2017). Emerging roles for the gut microbiome in autism spectrum disorder. Biological Psychiatry, 81(5), 411–423.CrossRefPubMed

Wassenaar, T. M., & Panigrahi, P. (2014). Is a foetus developing in a sterile environment? Letters in Applied Microbiology, 59(6), 572–579.CrossRefPubMed

Zetterqvist, J., Vansteelandt, S., Pawitan, Y., & Sjolander, A. (2016). Doubly robust methods for handling confounding by cluster. Biostatistics, 17(2), 264–276.CrossRefPubMed

Titel: Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs
Auteurs: Johan Isaksson
Erik Pettersson
Elzbieta Kostrzewa
Rochellys Diaz Heijtz
Sven Bölte
Publicatiedatum: 23-05-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3169-2

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