Skip to main content
Top
Gepubliceerd in: Child Psychiatry & Human Development 6/2011

01-12-2011 | Original Article

Characterization and Factors Associated with Sleep Quality in Adolescents with Bipolar I Disorder

Auteurs: Donna J. Roybal, Kiki D. Chang, Michael C. Chen, Meghan E. Howe, Ian H. Gotlib, Manpreet K. Singh

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 6/2011

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Sleep disturbance is an early marker for bipolar disorder (BD) onset in youth. We characterized sleep quality in adolescents experiencing mania within the last 6-12 months. We examined the association between mood and sleep in 27 adolescents with BD and 24 matched healthy controls (HC). Subjects were assessed by parent and teen report of sleep, a semi-structured clinical interview, the Young Mania Rating Scale (YMRS), and the Childhood Depression Rating Scale (CDRS-R). Average BD youth YMRS (mean 20.3 ± 7.3) and CDRS-R (mean 42.4 ± 14.1) scores indicated they were still ill at time of assessment. Compared to HCs, adolescents with BD have distinct patterns of prolonged sleep onset latency, frequent nighttime awakenings, and increased total time awake. Mood symptoms, specifically excessive guilt, self-injurious behavior, and worsening evening mood, interfered with sleep. Further studies are needed to determine whether early regulation of sleep would improve long-term outcome in BD youth.
Literatuur
1.
go back to reference Birmaher B, Axelson D, Strober M, Gill MK, Valeri S, Chiappetta L et al (2006) Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63:175–183PubMedCrossRef Birmaher B, Axelson D, Strober M, Gill MK, Valeri S, Chiappetta L et al (2006) Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63:175–183PubMedCrossRef
2.
go back to reference Carter TD, Mundo E, Parikh SV, Kennedy JL (2003) Early age at onset as a risk factor for poor outcome of bipolar disorder. J Psychiatry Res 37:297–303CrossRef Carter TD, Mundo E, Parikh SV, Kennedy JL (2003) Early age at onset as a risk factor for poor outcome of bipolar disorder. J Psychiatry Res 37:297–303CrossRef
3.
go back to reference Geller B, Craney JL, Bolhofner K, Nickelsburg MJ, Williams M, Zimerman B (2002) Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 159:927–933PubMedCrossRef Geller B, Craney JL, Bolhofner K, Nickelsburg MJ, Williams M, Zimerman B (2002) Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 159:927–933PubMedCrossRef
4.
go back to reference Geller B, DelBello MP (2003) Bipolar disorder in childhood and early adolescence. Guilford Press, New York Geller B, DelBello MP (2003) Bipolar disorder in childhood and early adolescence. Guilford Press, New York
5.
go back to reference Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP et al (2004) Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 55:875–881PubMedCrossRef Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP et al (2004) Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 55:875–881PubMedCrossRef
6.
go back to reference Togen M, Angst J (2002) Textbook in psychiatric epidemiology. Wiley-Liss, New York Togen M, Angst J (2002) Textbook in psychiatric epidemiology. Wiley-Liss, New York
7.
go back to reference Birmaher B, Axelson D, Goldstein B, Strober M, Gill MK, Hunt J et al (2009) Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the course and outcome of bipolar youth (COBY) study. Am J Psychiatry 166:795–804PubMedCrossRef Birmaher B, Axelson D, Goldstein B, Strober M, Gill MK, Hunt J et al (2009) Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the course and outcome of bipolar youth (COBY) study. Am J Psychiatry 166:795–804PubMedCrossRef
8.
go back to reference Goldstein TR, Birmaher B, Axelson D, Goldstein BI, Gill MK, Esposito-Smythers C et al (2009) Psychosocial functioning among bipolar youth. J Affect Disord 114:174–183PubMedCrossRef Goldstein TR, Birmaher B, Axelson D, Goldstein BI, Gill MK, Esposito-Smythers C et al (2009) Psychosocial functioning among bipolar youth. J Affect Disord 114:174–183PubMedCrossRef
9.
go back to reference Axelson D, Birmaher B, Strober M, Gill MK, Valeri S, Chiappetta L et al (2006) Phenomenology of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63:1139–1148PubMedCrossRef Axelson D, Birmaher B, Strober M, Gill MK, Valeri S, Chiappetta L et al (2006) Phenomenology of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63:1139–1148PubMedCrossRef
10.
go back to reference Harvey AG (2009) The adverse consequences of sleep disturbance in pediatric bipolar disorder: implications for intervention. Child Adolesc Psychiatry Clin N Am 18:321–338, viii Harvey AG (2009) The adverse consequences of sleep disturbance in pediatric bipolar disorder: implications for intervention. Child Adolesc Psychiatry Clin N Am 18:321–338, viii
11.
go back to reference Jackson A, Cavanagh J, Scott J (2003) A systematic review of manic and depressive prodromes. J Affect Disord 74:209–217PubMedCrossRef Jackson A, Cavanagh J, Scott J (2003) A systematic review of manic and depressive prodromes. J Affect Disord 74:209–217PubMedCrossRef
12.
go back to reference Staton D (2008) The impairment of pediatric bipolar sleep: hypotheses regarding a core defect and phenotype-specific sleep disturbances. J Affect Disord 108:199–206PubMedCrossRef Staton D (2008) The impairment of pediatric bipolar sleep: hypotheses regarding a core defect and phenotype-specific sleep disturbances. J Affect Disord 108:199–206PubMedCrossRef
13.
go back to reference American Psychiatric Association. and American Psychiatric Association. Task Force on DSM-IV (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association, Washington, DC American Psychiatric Association. and American Psychiatric Association. Task Force on DSM-IV (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association, Washington, DC
14.
go back to reference Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 35:773–782PubMed Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 35:773–782PubMed
15.
go back to reference Ballenger JC, Reus VI, Post RM (1982) The “atypical” clinical picture of adolescent mania. Am J Psychiatry 139:602–606PubMed Ballenger JC, Reus VI, Post RM (1982) The “atypical” clinical picture of adolescent mania. Am J Psychiatry 139:602–606PubMed
16.
go back to reference Lewinsohn PM, Klein DN, Seeley JR (1995) Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry 34:454–463PubMedCrossRef Lewinsohn PM, Klein DN, Seeley JR (1995) Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry 34:454–463PubMedCrossRef
17.
go back to reference Findling RL, Gracious BL, McNamara NK, Youngstrom EA, Demeter CA, Branicky LA et al (2001) Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disord 3:202–210PubMedCrossRef Findling RL, Gracious BL, McNamara NK, Youngstrom EA, Demeter CA, Branicky LA et al (2001) Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disord 3:202–210PubMedCrossRef
18.
go back to reference Bhangoo RK, Dell ML, Towbin K, Myers FS, Lowe CH, Pine DS et al (2003) Clinical correlates of episodicity in juvenile mania. J Child Adolesc Psychopharmacol 13:507–514PubMedCrossRef Bhangoo RK, Dell ML, Towbin K, Myers FS, Lowe CH, Pine DS et al (2003) Clinical correlates of episodicity in juvenile mania. J Child Adolesc Psychopharmacol 13:507–514PubMedCrossRef
19.
go back to reference Geller B, Tillman R, Craney JL, Bolhofner K (2004) Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry 61:459–467PubMedCrossRef Geller B, Tillman R, Craney JL, Bolhofner K (2004) Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry 61:459–467PubMedCrossRef
20.
go back to reference Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB (2004) Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disord 6:305–313PubMedCrossRef Faedda GL, Baldessarini RJ, Glovinsky IP, Austin NB (2004) Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disord 6:305–313PubMedCrossRef
21.
go back to reference Lofthouse N, Fristad M, Splaingard M, Kelleher K (2007) Parent and child reports of sleep problems associated with early-onset bipolar spectrum disorders. J Fam Psychol 21:114–123PubMedCrossRef Lofthouse N, Fristad M, Splaingard M, Kelleher K (2007) Parent and child reports of sleep problems associated with early-onset bipolar spectrum disorders. J Fam Psychol 21:114–123PubMedCrossRef
22.
go back to reference Kowatch RA, Youngstrom EA, Danielyan A, Findling RL (2005) Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord 7:483–496PubMedCrossRef Kowatch RA, Youngstrom EA, Danielyan A, Findling RL (2005) Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord 7:483–496PubMedCrossRef
23.
go back to reference Tillman R, Geller B, Craney JL, Bolhofner K, Williams M, Zimerman B (2004) Relationship of parent and child informants to prevalence of mania symptoms in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 161:1278–1284PubMedCrossRef Tillman R, Geller B, Craney JL, Bolhofner K, Williams M, Zimerman B (2004) Relationship of parent and child informants to prevalence of mania symptoms in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 161:1278–1284PubMedCrossRef
24.
go back to reference Parker G, Malhi G, Hadzi-Pavlovic D, Parker K (2006) Sleeping in? The impact of age and depressive sub-type on hypersomnia. J Affect Disord 90:73–76PubMedCrossRef Parker G, Malhi G, Hadzi-Pavlovic D, Parker K (2006) Sleeping in? The impact of age and depressive sub-type on hypersomnia. J Affect Disord 90:73–76PubMedCrossRef
25.
go back to reference Geller B, Zimerman B, Williams M, Delbello MP, Bolhofner K, Craney JL et al (2002) DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 12:11–25PubMedCrossRef Geller B, Zimerman B, Williams M, Delbello MP, Bolhofner K, Craney JL et al (2002) DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 12:11–25PubMedCrossRef
26.
go back to reference Faedda GL, Teicher MH (2005) Objective measures of activity and attention in the differential diagnosis of psychiatric disorders of childhood. Essent Psychopharmacol 6:239–249PubMed Faedda GL, Teicher MH (2005) Objective measures of activity and attention in the differential diagnosis of psychiatric disorders of childhood. Essent Psychopharmacol 6:239–249PubMed
27.
go back to reference Mehl RC, O’Brien LM, Jones JH, Dreisbach JK, Mervis CB, Gozal D (2006) Correlates of sleep and pediatric bipolar disorder. Sleep 29:193–197PubMed Mehl RC, O’Brien LM, Jones JH, Dreisbach JK, Mervis CB, Gozal D (2006) Correlates of sleep and pediatric bipolar disorder. Sleep 29:193–197PubMed
28.
go back to reference Rao U, Dahl RE, Ryan ND, Birmaher B, Williamson DE, Rao R et al (2002) Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course. J Affect Disord 70:273–280PubMedCrossRef Rao U, Dahl RE, Ryan ND, Birmaher B, Williamson DE, Rao R et al (2002) Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course. J Affect Disord 70:273–280PubMedCrossRef
30.
go back to reference Riemann D, Voderholzer U, Berger M (2002) Sleep and sleep-wake manipulations in bipolar depression. Neuropsychobiology 45(Suppl 1):7–12 Riemann D, Voderholzer U, Berger M (2002) Sleep and sleep-wake manipulations in bipolar depression. Neuropsychobiology 45(Suppl 1):7–12
31.
go back to reference Achenbach TM, McConaughy SH, Howell CT (1987) Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychol Bull 101:213–232PubMedCrossRef Achenbach TM, McConaughy SH, Howell CT (1987) Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychol Bull 101:213–232PubMedCrossRef
32.
go back to reference Ferdinand RF, van der Ende J, Verhulst FC (2004) Parent-adolescent disagreement regarding psychopathology in adolescents from the general population as a risk factor for adverse outcome. J Abnorm Psychol 113:198–206PubMedCrossRef Ferdinand RF, van der Ende J, Verhulst FC (2004) Parent-adolescent disagreement regarding psychopathology in adolescents from the general population as a risk factor for adverse outcome. J Abnorm Psychol 113:198–206PubMedCrossRef
33.
go back to reference Youngstrom EA, Findling RL, Calabrese JR (2004) Effects of adolescent manic symptoms on agreement between youth, parent, and teacher ratings of behavior problems. J Affect Disord 82(Suppl 1):S5–S16 Youngstrom EA, Findling RL, Calabrese JR (2004) Effects of adolescent manic symptoms on agreement between youth, parent, and teacher ratings of behavior problems. J Affect Disord 82(Suppl 1):S5–S16
34.
go back to reference Owens JA, Spirito A, McGuinn M, Nobile C (2000) Sleep habits and sleep disturbance in elementary school-aged children. J Dev Behav Pediatr 21:27–36PubMedCrossRef Owens JA, Spirito A, McGuinn M, Nobile C (2000) Sleep habits and sleep disturbance in elementary school-aged children. J Dev Behav Pediatr 21:27–36PubMedCrossRef
35.
go back to reference Grills AE, Ollendick TH (2003) Multiple informant agreement and the anxiety disorders interview schedule for parents and children. J Am Acad Child Adolesc Psychiatry 42:30–40PubMedCrossRef Grills AE, Ollendick TH (2003) Multiple informant agreement and the anxiety disorders interview schedule for parents and children. J Am Acad Child Adolesc Psychiatry 42:30–40PubMedCrossRef
36.
go back to reference Carskadon MA (1990) Patterns of sleep and sleepiness in adolescents. Pediatrician 17:5–12PubMed Carskadon MA (1990) Patterns of sleep and sleepiness in adolescents. Pediatrician 17:5–12PubMed
37.
go back to reference Hollinghead A (1975) Four-factor index of social status. Yale University, New Haven Hollinghead A (1975) Four-factor index of social status. Yale University, New Haven
38.
go back to reference Geller B, Williams M, Zimerman B, Frazier J (1996) Washington University in St. Louis Kiddie Schedule for affective disorders and schizophrenia (WASH-U-KSADS). Washington University, St. Louis Geller B, Williams M, Zimerman B, Frazier J (1996) Washington University in St. Louis Kiddie Schedule for affective disorders and schizophrenia (WASH-U-KSADS). Washington University, St. Louis
39.
go back to reference Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429–435PubMedCrossRef Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429–435PubMedCrossRef
40.
go back to reference Poznanski EO, Grossman JA, Buchsbaum Y, Banegas M, Freeman L, Gibbons R (1984) Preliminary studies of the reliability and validity of the children’s depression rating scale. J Am Acad Child Psychiatry 23:191–197PubMedCrossRef Poznanski EO, Grossman JA, Buchsbaum Y, Banegas M, Freeman L, Gibbons R (1984) Preliminary studies of the reliability and validity of the children’s depression rating scale. J Am Acad Child Psychiatry 23:191–197PubMedCrossRef
41.
go back to reference Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H et al (1983) A children’s global assessment scale (CGAS). Arch Gen Psychiatry 40:1228–1231PubMed Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H et al (1983) A children’s global assessment scale (CGAS). Arch Gen Psychiatry 40:1228–1231PubMed
42.
go back to reference Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213PubMedCrossRef Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213PubMedCrossRef
43.
go back to reference Nowlin-Finch NL, Altshuler LL, Szuba MP, Mintz J (1994) Rapid resolution of first episodes of mania: sleep related? J Clin Psychiatry 55:26–29PubMed Nowlin-Finch NL, Altshuler LL, Szuba MP, Mintz J (1994) Rapid resolution of first episodes of mania: sleep related? J Clin Psychiatry 55:26–29PubMed
44.
go back to reference Barbini B, Bertelli S, Colombo C, Smeraldi E (1996) Sleep loss, a possible factor in augmenting manic episode. Psychiatry Res 65:121–125PubMedCrossRef Barbini B, Bertelli S, Colombo C, Smeraldi E (1996) Sleep loss, a possible factor in augmenting manic episode. Psychiatry Res 65:121–125PubMedCrossRef
45.
go back to reference Plante DT, Winkelman JW (2008) Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry 165:830–843PubMedCrossRef Plante DT, Winkelman JW (2008) Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry 165:830–843PubMedCrossRef
46.
go back to reference Cloutier P, Martin J, Kennedy A, Nixon MK, Muehlenkamp JJ (2010) Characteristics and co-occurrence of adolescent non-suicidal self-injury and suicidal behaviours in pediatric emergency crisis services. J Youth Adolesc 39:259–269PubMedCrossRef Cloutier P, Martin J, Kennedy A, Nixon MK, Muehlenkamp JJ (2010) Characteristics and co-occurrence of adolescent non-suicidal self-injury and suicidal behaviours in pediatric emergency crisis services. J Youth Adolesc 39:259–269PubMedCrossRef
47.
go back to reference Swann AC, Moeller FG, Steinberg JL, Schneider L, Barratt ES, Dougherty DM (2007) Manic symptoms and impulsivity during bipolar depressive episodes. Bipolar Disord 9:206–212PubMedCrossRef Swann AC, Moeller FG, Steinberg JL, Schneider L, Barratt ES, Dougherty DM (2007) Manic symptoms and impulsivity during bipolar depressive episodes. Bipolar Disord 9:206–212PubMedCrossRef
48.
go back to reference Goldstein TR, Birmaher B, Axelson D, Ryan ND, Strober MA, Gill MK et al (2005) History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk. Bipolar Disord 7:525–535PubMedCrossRef Goldstein TR, Birmaher B, Axelson D, Ryan ND, Strober MA, Gill MK et al (2005) History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk. Bipolar Disord 7:525–535PubMedCrossRef
49.
go back to reference Schmidt RE, Van der Linden M (2009) The aftermath of rash action: sleep-interfering counterfactual thoughts and emotions. Emotion 9:549–553PubMedCrossRef Schmidt RE, Van der Linden M (2009) The aftermath of rash action: sleep-interfering counterfactual thoughts and emotions. Emotion 9:549–553PubMedCrossRef
50.
go back to reference Schmidt RE, Gay P, Ghisletta P, VDL M (2010) Linking impulsivity to dysfunctional thought control and insomnia: a structural equation model. J Sleep Res 19:3–11PubMedCrossRef Schmidt RE, Gay P, Ghisletta P, VDL M (2010) Linking impulsivity to dysfunctional thought control and insomnia: a structural equation model. J Sleep Res 19:3–11PubMedCrossRef
51.
go back to reference Goldberg JF, McLeod LD, Fehnel SE, Williams VS, Hamm LR, Gilchrist K (2010) Development and psychometric evaluation of the bipolar functional status questionnaire (BFSQ). Bipolar Disord 12:32–44PubMedCrossRef Goldberg JF, McLeod LD, Fehnel SE, Williams VS, Hamm LR, Gilchrist K (2010) Development and psychometric evaluation of the bipolar functional status questionnaire (BFSQ). Bipolar Disord 12:32–44PubMedCrossRef
52.
go back to reference Ohayon MM, Priest RG, Zulley J, Smirne S (2000) The place of confusional arousals in sleep and mental disorders: findings in a general population sample of 13, 057 subjects. J Nerv Ment Dis 188:340–348PubMedCrossRef Ohayon MM, Priest RG, Zulley J, Smirne S (2000) The place of confusional arousals in sleep and mental disorders: findings in a general population sample of 13, 057 subjects. J Nerv Ment Dis 188:340–348PubMedCrossRef
53.
go back to reference Harvey AG (2008) Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatry 165:820–829PubMedCrossRef Harvey AG (2008) Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatry 165:820–829PubMedCrossRef
54.
go back to reference McClung CA (2007) Clock genes and bipolar disorder: implications for therapy. Pharmacogenomics 8:1097–1100PubMedCrossRef McClung CA (2007) Clock genes and bipolar disorder: implications for therapy. Pharmacogenomics 8:1097–1100PubMedCrossRef
55.
go back to reference Hlastala SA, Kotler JS, McClellan JM, McCauley EA (2010) Interpersonal and social rhythm therapy for adolescents with bipolar disorder: treatment development and results from an open trial. Depress Anxiety 27:457–464PubMedCrossRef Hlastala SA, Kotler JS, McClellan JM, McCauley EA (2010) Interpersonal and social rhythm therapy for adolescents with bipolar disorder: treatment development and results from an open trial. Depress Anxiety 27:457–464PubMedCrossRef
56.
go back to reference Frye MA, Grunze H, Suppes T, McElroy SL, Keck PE Jr, Walden J et al (2007) A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression. Am J Psychiatry 164:1242–1249PubMedCrossRef Frye MA, Grunze H, Suppes T, McElroy SL, Keck PE Jr, Walden J et al (2007) A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression. Am J Psychiatry 164:1242–1249PubMedCrossRef
Metagegevens
Titel
Characterization and Factors Associated with Sleep Quality in Adolescents with Bipolar I Disorder
Auteurs
Donna J. Roybal
Kiki D. Chang
Michael C. Chen
Meghan E. Howe
Ian H. Gotlib
Manpreet K. Singh
Publicatiedatum
01-12-2011
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 6/2011
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-011-0239-0

Andere artikelen Uitgave 6/2011

Child Psychiatry & Human Development 6/2011 Naar de uitgave