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Gepubliceerd in: Kind en adolescent 1/2016

10-02-2016 | Opmerkelijk

(Kandidaat-)genen in onderzoek naar psychopathologie: einde van een tijdperk?

Auteur: Joyce Weeland, MSc

Gepubliceerd in: Kind en adolescent | Uitgave 1/2016

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‘Een verspilling van belastinggeld’, zo noemde het National Institute of Mental Health (NIMH, een van Amerika’s grootste subsidieverstrekkers) studies naar psychopathologie die gebruikmaken van kandidaat-genen. De term kandidaat-gen heeft betrekking op enkele genen die mogelijk direct, en/of in interactie met de omgeving, in verband staan met psychopathologie (voorbeelden daarvan zijn de DRD4, DRD2, 5-HTT, MAOA en COMT). Deze genen hebben verschillende veelvoorkomende varianten, ofwel polymorfismen, die invloed op de expressie van dit gen hebben. Bijvoorbeeld, het MAOA-gen (welke codeert voor het MAOA-enzym dat onder meer dopamine en serotonine afbreekt) heeft een ‘low-functioning’- en een ‘high-functioning’-allel. Vergeleken met het ‘high-functioning’-allel zorgt het ‘low-functioning’-allel voor verlaagde gen-expressie, minder MAOA, vervolgens meer dopamine en serotonine in de hersenen, en meer agressie in dragers van dit allel, vooral in combinatie met risico’s uit de omgeving (Byrd en Manuck 2014; Vernaleken et al. 2015). …
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Metagegevens
Titel
(Kandidaat-)genen in onderzoek naar psychopathologie: einde van een tijdperk?
Auteur
Joyce Weeland, MSc
Publicatiedatum
10-02-2016
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Kind en adolescent / Uitgave 1/2016
Print ISSN: 0167-2436
Elektronisch ISSN: 1876-5998
DOI
https://doi.org/10.1007/s12453-015-0108-x

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