Respiratory sinus arrhythmia: a transdiagnostic biomarker of emotion dysregulation and psychopathology
Introduction
Although the study of human emotion can be traced at least as far back as Darwin [1], for much of the 20th century psychological science was dominated by behavioral and cognitive paradigms that viewed emotional states as subjective, unquantifiable, and unamenable to scientific inquiry [2]. Beginning in the mid-1990s, these paradigms gave way to the contemporary view that emotional experience and expression are integral to both positive and negative psychological adjustment. This paradigm shift was facilitated by several developments, including a 1990, yearlong seminar on emotion held at the National Institute of Mental Health, and a 1991 conference on the development of emotion regulation (ER) that was sponsored by the John D. and Catherine T. MacArthur Foundation Early Childhood Network. From these, landmark volumes on the nature of emotion [3] and ER [4] emerged. Among other important contributions, chapters in these volumes demonstrated how emotional states can be inferred, verified, and quantified by measuring appropriate biological systems [5, 6, 7]. The study of emotion soon became mainstream, and is currently central to the positive and negative valence systems of the Research Domain Criteria (RDoC) [8•].
Section snippets
Emotion dysregulation and psychopathology
It is now widely recognized that problems with ER confer vulnerability to a wide range of psychopathological outcomes [9•], and that difficulties with ER characterize almost all forms of psychopathology [10•, 11•]. ER can be defined as the set of processes through which emotional experience and expression are shaped in the service of adaptive behavior [12]. Such shaping of emotion may occur through various mechanisms, including attentional, cognitive, social, and behavioral [13•]. In contrast,
Central nervous system substrates of emotion dysregulation
Recognition that emotion dysregulation plays such a prominent role in vulnerability to psychopathology has led to considerable research on its central nervous system (CNS) substrates. Taken together, this research demonstrates that ER is subserved by top–down, cortical (prefrontal) brain networks that mature into the early 20s [17•, 18•, 19•]. Trait anxiety, which confers vulnerability to internalizing disorders (e.g., anxiety, depression), is volitionally regulated through prefrontal
Peripheral nervous system markers of emotion dysregulation
Although the CNS substrates of ER are well characterized [16•], measuring CNS processes requires neuroimaging protocols that are expensive, limited in ecological validity, and difficult to use with certain populations, such as young children and those with severe psychopathology. For these reasons and others, many researchers have turned to peripheral nervous system markers of ER, most notably respiratory sinus arrhythmia (RSA). The term RSA refers to ebbing and flowing of heart rate (HR)
Conclusions
A primary aim of psychophysiological research is to use peripheral measures to make inferences about CNS processes that are difficult and in some cases impossible to index noninvasively [26•]. However, much of the literature on RSA-behavior relations is either agnostic with respect to central nervous system substrates of RSA, or implies that the PNS plays a causal role in ER. As reviewed above, it is far more likely that the PNS — via the vagus nerve — mediates links between the PFC and
References and recommended reading
Papers of particular interest, published within the period of review, have been highlighted as:
• of special interest
•• of outstanding interest
References (48)
- et al.
Comorbidities and continuities as ontogenic processes: toward a developmental spectrum model of externalizing behavior
Dev Psychopathol
(2013) Anxiety and affective style: role of prefrontal cortex and amygdala
Biol Psychiat
(2002)- et al.
Correspondence between physiological and self-report measures of emotion dysregulation: a longitudinal investigation of youth with and without psychopathology
J Child Psychol Psych
(2009) - et al.
Parental socialization, vagal regulation, and preschoolers’ anxious difficulties: direct mothers and moderated fathers
Child Dev
(2008) - et al.
Vagal influence in the regulation of attention and working memory
Int J Psychophysiol
(2003) The Expression of the Emotions in Man and Animals
(1872)- Beauchaine TP, Zalewski M: Physiological and developmental mechanisms of emotional liability in coercive relationships....
- et al.
The Nature of Emotion
(1994) - et al.
Vagal tone and the physiological regulation of emotion
Monogr Soc Res Child
(1994)
Frontal electroencephalographic correlates of individual differences in emotion expression in infants: a brain systems perspective on emotion
Monogr Soc Res Child
The clearest physiological distinctions between emotions will be found in the brain
Emotion dysregulation as a risk factor for psychopathology
Vagal tone, development, and Gray's motivational theory: toward an integrated model of autonomic nervous system functioning in psychopathology
Dev Psychopathol
Emotion and self-regulation
Emotion regulation strategies and psychopathology: a meta-analysis
Clin Psychol Rev
Instantiating the multiple levels of analysis perspective in a program of study on externalizing behavior
Dev Psychopathol
Polyvagal theory and developmental psychopathology: emotion dysregulation and conduct problems from preschool to adolescence
Biol Psychol
Dynamic mapping of human cortical development during childhood through early adulthood
Proc Natl Acad Sci USA
Cognitive neuroscience of self-regulation failure
Trends Cogn Sci
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