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01-12-2011

Geslachtshormonen en hersenontwikkeling in de puberteit

Auteur: Mw. dr. J.S. Peper

Gepubliceerd in: Neuropraxis | Uitgave 6/2011

Samenvatting

De puberteit is een belangrijke periode gedurende de ontwikkeling die wordt gekenmerkt door een sterke toename in geslachtshormonen. Studies die gebruikmaken van beeldvormingtechnieken, zoals MRI, rapporteren veelvuldig dat de hersenen van gezonde kinderen in de puberteit anatomische veranderingen ondergaan. Het proces van anatomische reorganisatie in de puberteit zou kunnen wijzen op het ‘fine-tunen’ van neuronale netwerken. Deze bewering wordt gesterkt door dierexperimenteel onderzoek, waaruit blijkt dat geslachtshormonen een directe invloed hebben op de vertakking van dendrieten (‘grijze stof’) en de vorming van myeline om axonen (‘witte stof’). Een belangrijke vraag die nu rijst is in hoeverre puberteitshormonen bijdragen aan hersenontwikkeling bij mensen. Dit artikel bespreekt de mogelijke evidentie voor de rol die geslachtshormonen spelen bij de ontwikkeling van grijze en witte stof. We kunnen concluderen dat individuele verschillen in de modulatie van geslachtshormonen op de organisatie van de hersenen aanknopingspunten geven om typisch gedrag in de puberteit te verklaren, zoals verhoogde gevoeligheid voor beloningen, risicogedrag en cognitieve flexibiliteit.

vorige artikel Taallateralisatie en handvoorkeur: Is er een verband met prenatale blootstelling aan testosteron?

volgende artikel Effect van tekort en suppletie van groeihormoon en insuline-achtige groeifactor-I op hersenfuncties

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Titel: Geslachtshormonen en hersenontwikkeling in de puberteit
Auteur: Mw. dr. J.S. Peper
Publicatiedatum: 01-12-2011
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Neuropraxis / Uitgave 6/2011
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI: https://doi.org/10.1007/s12474-011-0032-7

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